Youan Liu
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Author Swipe
View article: Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy
Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy Open
Regardless of its underlying causes, progressive chronic kidney disease is characterized by progressive kidney fibrosis. The adenosine A2a receptor is expressed by activated kidney fibroblasts. Istradefylline is an adenosine A2a receptor a…
View article: Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice
Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice Open
Epigenetic processes have emerged as important modulators of kidney health and disease. Here, we studied the role of KDM6A (a histone demethylase that escapes X-chromosome inactivation) in kidney tubule epithelial cells. We initially obser…
View article: Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure
Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure Open
Inflammation promotes adverse ventricular remodeling, a common antecedent of heart failure. Here, we set out to determine how inflammatory cells affect cardiomyocytes in the remodeling heart. Pathogenic cardiac macrophages induced an IFN r…
View article: Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21
Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21 Open
Background and Purpose Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) and G‐protein coupled receptors (GPCRs) are the most druggable therapeutic targets. Here, we set out to establish a transcriptional profil…
View article: The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Directly Enhances the Contractile Recovery of Mouse Hearts at a Concentration Equivalent to that Achieved with Standard Dosing in Humans
The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Directly Enhances the Contractile Recovery of Mouse Hearts at a Concentration Equivalent to that Achieved with Standard Dosing in Humans Open
Despite a similar mechanism of action underlying their glucose-lowering effects in type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors have diverse molecular structures, raising the prospect of agent-specific, glucose-independent ac…
View article: Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease
Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease Open
View article: HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease
HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease Open
To contend with the deleterious effects of accumulating misfolded protein aggregates or damaged organelles cells rely on a system of quality control processes, among them the autophagy-lysosome pathway. This pathway is itself controlled by…
View article: Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease
Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease Open
Histone protein modifications control fate determination during normal development and dedifferentiation during disease. Here, we set out to determine the extent to which dynamic changes to histones affect the differentiated phenotype of o…
View article: EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease
EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease Open
The therapeutic targeting of prostanoid subtype receptors may slow the development of chronic kidney disease (CKD) through mechanisms that are distinct from those of upstream COX inhibition. Here, employing multiple experimental models of …
View article: Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes
Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes Open
The nonreceptor kinase Janus kinase 2 (JAK2) has garnered attention as a promising therapeutic target for the treatment of CKD. However, being ubiquitously expressed in the adult, JAK2 is also likely to be necessary for normal organ functi…
View article: Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms
Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms Open
Discovery of common pathways that mediate both pancreatic β-cell function and end-organ function offers the opportunity to develop therapies that modulate glucose homeostasis and separately slow the development of diabetes complications. H…