Youhani Samarakoon
YOU?
Author Swipe
View article: Figure S7 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S7 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 7
View article: Figure S5 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S5 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 5
View article: Figure S3 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S3 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 3
View article: Figure S2 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S2 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 2
View article: Figure S10 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S10 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 10
View article: Data from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Data from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Tumor-associated macrophages (TAM) are a universal feature of cancers but variably influence outcomes and treatment responses. In this study, we used a photoconvertible mouse to distinguish newly entering, monocyte-derived TAMs (mdTAM) tha…
View article: Figure S8 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S8 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 8
View article: Supplementary table 1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Supplementary table 1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Antibodies and reagents
View article: Figure S1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S1 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 1
View article: Figure S6 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S6 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 6
View article: Figure S4 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S4 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 4
View article: Figure S9 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
Figure S9 from <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Supplementary figure 9
View article: <i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade
<i>In Vivo</i> Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade Open
Tumor-associated macrophages (TAM) are a universal feature of cancers but variably influence outcomes and treatment responses. In this study, we used a photoconvertible mouse to distinguish newly entering, monocyte-derived TAMs (mdTAM) tha…
View article: CRISPR screens in the context of immune selection identify <i>CHD1</i> and <i>MAP3K7</i> as mediators of cancer immunotherapy resistance
CRISPR screens in the context of immune selection identify <i>CHD1</i> and <i>MAP3K7</i> as mediators of cancer immunotherapy resistance Open
Summary Cancer immunotherapy is only effective in a subset of patients, highlighting the need for effective biomarkers and combination therapies. Here we systematically identify genetic determinants of cancer cell sensitivity to anti-tumor…
View article: UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia
UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia Open
T-cell receptor recognition of cognate peptide–MHC leads to the formation of signalling domains and the immunological synapse. Because of the close membrane apposition, there is rapid exclusion of CD45, and therefore LCK activation. Much l…
View article: Cross-talk between ILC2 and Gata3 <sup>high</sup> T <sub>regs</sub> locally constrains adaptive type 2 immunity
Cross-talk between ILC2 and Gata3 <sup>high</sup> T <sub>regs</sub> locally constrains adaptive type 2 immunity Open
Regulatory T cells (T regs ) control adaptive immunity and restrain type 2 inflammation in allergic disease. Interleukin-33 promotes the expansion of tissue-resident T regs and group 2 innate lymphoid cells (ILC2s); however, how T regs loc…
View article: Fluorogenic Granzyme A Substrates Enable Real‐Time Imaging of Adaptive Immune Cell Activity
Fluorogenic Granzyme A Substrates Enable Real‐Time Imaging of Adaptive Immune Cell Activity Open
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon recognition of cancer cells; however, ther…
View article: Fluorogenic Granzyme A Substrates Enable Real‐Time Imaging of Adaptive Immune Cell Activity
Fluorogenic Granzyme A Substrates Enable Real‐Time Imaging of Adaptive Immune Cell Activity Open
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon recognition of cancer cells; however, ther…
View article: The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms
The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms Open
Two paralogs of the guanine dissociation inhibitor-like solubilizing factors UNC119, UNC119A and UNC119B, are present in the human genome. UNC119 binds to N-myristoylated proteins and masks the hydrophobic lipid from the hydrophilic cytoso…
View article: ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses
ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses Open
The primary cilium and the immunological synapse are both specialized functional plasma membrane domains that share several similarities. Signalling output of membrane domains is regulated, spatially and temporally, by segregating and focu…