Explanipedia

Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models Open

Haruna Kimura, Akito Hasegawa, Tomoki Nishiguchi, Hong Ha Nguyen, Masatoshi Eguchi , et al. · 2025

Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening mucocutaneous adverse drug reactions characterized by disseminated skin and mucosal detachment. Mortality rates remain high and have increased in recent years, hi…

The diagnostic challenge of melanoma with myxoid change mimicking metastatic soft tissue sarcoma Open

Jiro Ichikawa, Youichi Ogawa, Tomonori Kawasaki, Y. Fukushima, Masanori Wako , et al. · 2025

A deep learning–clinical nomogram hybrid for predicting sentinel lymph node metastasis in melanoma Open

Minh‐Khang Le, Masataka Kawai, Tetsuo Kondo, Takashi Inozume, Yoshinori Muto , et al. · 2025

Background Melanoma is a life‐threatening skin malignancy, with sentinel lymph node metastasis (SLNM) serving as a critical prognostic factor. While machine and deep learning models using histopathology have focused on melanoma diagnosis, …

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition Open

Yoshihide Asano, Jun Asai, Takeshi Ishii, Yohei Iwata, Masanari Kodera , et al. · 2025

Numerical, Phenotypic and Functional Differences in Human Dermal Resident Memory T Cells Between Reticular Dermal Layers Open

Takuya Sato, Riko Asakawa, Youichi Ogawa, Yuka Nagasaka, Manao Kinoshita , et al. · 2024

Background Resident memory T (TRM) cells and immunosuppressive Foxp3-expressing regulatory TRM (regTRM) cells are present in healthy, non-inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with…

Two cases of hydroa vacciniforme lymphoproliferative disorder in elderly patients: Excellent response to narrow-band ultraviolet B phototherapy Open

Ozumi Tomita, Mariko Iwasaki, Hiroshi Mitsui, Yoshinori Muto, Takashi Okamoto , et al. · 2024

Recent progress in Stevens–Johnson syndrome/toxic epidermal necrolysis: diagnostic criteria, pathogenesis and treatment Open

Natsumi Hama, Shigeki Aoki, Chun‐Bing Chen, Akito Hasegawa, Youichi Ogawa , et al. · 2024

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a severe spectrum of rare mucocutaneous reactions that are primarily drug-induced and characterized by significant morbidity and mortality. These conditions mani…

Efficacy and safety of intravenous fosphenytoin for patients with acute herpes zoster‐associated pain: A placebo‐controlled randomized trial Open

Masako Iseki, Takenobu Yamamoto, Youichi Ogawa, Yuta Majima, Yoichiro Abe , et al. · 2023

Acute zoster‐associated pain develops in most patients with herpes zoster. Nonopioid analgesics are usually used to treat acute zoster‐associated pain but are frequently ineffective. We administered intravenous fosphenytoin, the prodrug of…

Drug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms: Predictive Score and Outcomes Open

Yoshiko Mizukawa, Natsumi Hama, Fumi Miyagawa, Hayato Takahashi, Youichi Ogawa , et al. · 2023

Unusual enthesitis in a patient with Behçet’s syndrome Open

Shunichiro Hanai, Youichi Ogawa, Akiko Honobe‐Tabuchi, Yoshiaki Kobayashi, Daiki Nakagomi · 2023

058 Human Epithelial Resident Memory Regulatory T Cells Open

T Sato, Youichi Ogawa, Kazunori Yokoi, Ryo Watanabe, Shoichi Shimada , et al. · 2022

385 Purinergic molecules in murine mast cells Open

Youichi Ogawa, Riko Asakawa, Shoichi Shimada, T. Kawamura · 2022

Characterization of human epithelial resident memory regulatory T cells Open

Takuya Sato, Youichi Ogawa, Kazunori Yokoi, Yuka Nagasaka, Aoha Ishikawa , et al. · 2022

Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin. Considering that thick dermis contains more Tregs than thin epide…

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation Open

Toshiyuki Oda, Haruaki Yanagisawa, Hideyuki Shinmori, Youichi Ogawa, Tatsuyoshi Kawamura · 2022

Langerhans cells are specialized antigen-presenting cells localized within the epidermis and mucosal epithelium. Upon contact with Langerhans cells, pathogens are captured by the C-type lectin langerin and internalized into a structurally …

Author response: Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation Open

Toshiyuki Oda, Haruaki Yanagisawa, Hideyuki Shinmori, Youichi Ogawa, Tatsuyoshi Kawamura · 2022

Revisiting the Experimental Methods for Human Skin T-Cell Analysis Open

Takuya Sato, Youichi Ogawa, Aoha Ishikawa, Yuka Nagasaka, Manao Kinoshita , et al. · 2022

Tissue Expander-associated T Cells: Relevance to Breast Implant-associated Anaplastic Large-cell Lymphoma. Open

Ichiro Shiokawa, Takuya Sato, Youichi Ogawa, Yuka Nagasaka, Aoha Ishikawa , et al. · 2022

Textured and smooth TEs differentially recruit and/or differentiate T cells in situ.

Tissue Expander–associated T Cells: Relevance to Breast Implant–associated Anaplastic Large-cell Lymphoma Open

Ichiro Shiokawa, Takuya Sato, Youichi Ogawa, Yuka Nagasaka, Aoha Ishikawa , et al. · 2022

Background: The generation of breast implant–associated anaplastic large-cell lymphoma (BIA-ALCL) is closely associated with textured implants. The phenotype of BIA-ALCL cells is well examined, but its cell of origin remains unknown. Here …

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation Open

Toshiyuki Oda, Haruaki Yanagisawa, Hideyuki Shinmori, Youichi Ogawa, Tatsuyoshi Kawamura · 2022

Langerhans cells are specialized antigen-presenting cells localized within the epidermis and mucosal epithelium. Upon contact with Langerhans cells, pathogens are captured by the C- type lectin langerin and internalized into a structurally…

CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation Open

Aoi Okubo, Youhei Uchida, Yuko Higashi, Takuya Sato, Youichi Ogawa , et al. · 2021

Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147/basigin, an integral transmembrane protein belonging to the immunoglobulin superfam…

Neutrophil Extracellular Traps in Skin Diseases Open

Youichi Ogawa, Yoshinori Muto, Manao Kinoshita, Shinji Shimada, Tatsuyoshi Kawamura · 2021

Neutrophils are the primary innate immune cells, and serve as sentinels for invading pathogens. To this end, neutrophils exert their effector functions via phagocytosis, degranulation, reactive oxygen species generation, and neutrophil ext…

Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis Open

Manao Kinoshita, Youichi Ogawa, Natsumi Hama, Inkin Ujiie, Akito Hasegawa , et al. · 2021

Neutrophil extracellular traps induced by drug-specific CD8 + T cells initiate SJS/TEN.

A single－institute experience with immune－related adverse events caused by immune checkpoint inhibitors Open

Yoshinori Muto, Nobuhiro Deguchi, Takashi Inozume, Hiroshi Mitsui, Youichi Ogawa , et al. · 2021

2014年12月から2021年2月に当科で免疫チェックポイント阻害剤を使用した38例（悪性黒色腫36例，メルケル細胞癌2例）における免疫関連有害事象の発生状況を後ろ向きに検証した。のべ投与症例数の内訳はニボルマブ単剤16例，ペンブロリズマブ単剤20例，イピリムマブ単剤6例，ニボルマブ・イピリムマブ併用療法10例，アベルマブ単剤2例であった。免疫関連有害事象の発生頻度は単剤，併用療法でそれぞれ72.7％，90.0％，grade3，4が22.7％および40.0％であった。多臓器…

Zinc and Skin Open

Youichi Ogawa, Tatsuyoshi Kawamura · 2019

亜鉛はすべての生物の生存維持に不可欠な必須微量元素であり，継続的な亜鉛欠乏は死に至る。それにも関わらず，全世界人口の 17％(13 億人)が亜鉛欠乏(60 μg/dl 未満)，あるいは潜在的亜鉛欠乏(60∼80 μg/dl 未満)状態であるとされる。亜鉛は生体内で鉄に次いで 2 番目に含有量が多く，ヒトは 2∼3 g の亜鉛を含有する。亜鉛は 1000 以上の酵素反応，20,000 以上の転写調節因子発現やその機能に関与する。さらにヒト蛋白の約 10％が亜鉛と結合しうる。し…

Biotin Is Required for the Zinc Homeostasis in the Skin Open

Youichi Ogawa, Manao Kinoshita, Takuya Sato, Shinji Shimada, Tatsuyoshi Kawamura · 2019

Patients with biotin deficiency present symptoms that are similar to those in patients with acrodermatitis enteropathica (inherent zinc deficiency). However, the association between biotin and zinc deficiency remains unknown. We have previ…

482 GRL-142, a novel HIV-1 protease inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium Open

Youichi Ogawa, Shinji Shimada, Hiroaki Mitsuya, Tatsuyoshi Kawamura · 2019

Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis Open

Youichi Ogawa, Manao Kinoshita, Shinji Shimada, Tatsuyoshi Kawamura · 2018

In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining sk…

Zinc and Skin Disorders Open

Youichi Ogawa, Manao Kinoshita, Shinji Shimada, Tatsuyoshi Kawamura · 2018

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions …

DLX3-Dependent STAT3 Signaling in Keratinocytes Regulates Skin Immune Homeostasis Open

Shreya Bhattacharya, Jin‐Chul Kim, Youichi Ogawa, Gaku Nakato, Veronica L. Nagle , et al. · 2017

Epidermal-specific deletion of the homeobox transcription regulator DLX3 disrupts keratinocyte differentiation and results in an IL-17-linked psoriasis-like skin inflammation. To identify the epidermal initiating signals produced by DLX3-n…

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