Yutao Li
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View article: Analysis of lymph node recurrence patterns and risk factors in locally advanced esophageal carcinoma following neoadjuvant therapy
Analysis of lymph node recurrence patterns and risk factors in locally advanced esophageal carcinoma following neoadjuvant therapy Open
Background Although neoadjuvant therapy followed by surgery is the standard treatment for resectable locally advanced esophageal carcinoma, heterogeneity exists in neoadjuvant regimens within real-world practice. This study characterizes l…
View article: In-depth analysis of the characteristics of volatile organic compounds in wines: a systematic study integrating intelligent sensory and metabolomics techniques with chemometrics and machine learning models
In-depth analysis of the characteristics of volatile organic compounds in wines: a systematic study integrating intelligent sensory and metabolomics techniques with chemometrics and machine learning models Open
The volatile organic compounds (VOCs) in wines of 'Dornfelder' (DF), 'Petit Verdot' (PV), 'Pinot Noir' (PN), 'Sangiovese' (SV) and 'Malbec' (MB) were analyzed using an E-nose, HS-SPME-GC-MS and HS-GC-IMS. A total of 94 VOCs were identified…
View article: Spatial heterogeneity of cultural ecosystem services in grand canal rural heritage sites: A community gradient framework using participatory mapping
Spatial heterogeneity of cultural ecosystem services in grand canal rural heritage sites: A community gradient framework using participatory mapping Open
Rural heritage landscapes provide vital Cultural Ecosystem Services (CES) for sustainability, but local stakeholder roles and CES spatial variations across community gradients are often overlooked, causing governance deficiencies and confl…
View article: The impact of film audio description style on presence in Chinese visually impaired audiences
The impact of film audio description style on presence in Chinese visually impaired audiences Open
This study investigates the impact of film audio description (AD) styles on dimensions of presence—spatial presence, engagement, ecological validity, and negative effects—among visually impaired audiences in China. Two distinct styles of A…
View article: Transcriptomic Analysis of Skin Tissue Reveals Molecular Mechanisms of Thermal Adaptation in Cold-Exposed Lambs
Transcriptomic Analysis of Skin Tissue Reveals Molecular Mechanisms of Thermal Adaptation in Cold-Exposed Lambs Open
Cold stress impacts lamb mortality, welfare, and productivity. Wool and skin insulate lambs, but the mechanisms underlying their response to colder environments remain unclear. Shorn lambs (n = 20) of similar age (8 months), of the Hulunbu…
View article: Celastrol loaded nanocomplex for painless tumor therapy via YAP inhibition
Celastrol loaded nanocomplex for painless tumor therapy via YAP inhibition Open
Cancer-related pain is prevalent and severely impairs patients' quality of life. However, conventional cancer therapies primarily target tumor cell destruction, often overlooking the management of cancer pain. Thus, there is an immediate n…
View article: Enhancing the purity and intrinsic properties of ovine dermal papilla cells through flow cytometry sorting and cellular interactions
Enhancing the purity and intrinsic properties of ovine dermal papilla cells through flow cytometry sorting and cellular interactions Open
Objective: Dermal Papilla Cells (DPCs) play a crucial role in regulating hair follicle development and serve as a valuable in vitro model for screening and analyzing the genes associated with this process. However, current methods for isol…
View article: The association between sports social capital and cognitive health: A longitudinal study of middle-aged and elderly adults in China
The association between sports social capital and cognitive health: A longitudinal study of middle-aged and elderly adults in China Open
View article: Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment
Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment Open
View article: Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers—Metabolic Hormones
Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers—Metabolic Hormones Open
The extent of endocrine changes in response to various levels of heat stress and subsequent recovery is not well understood. Two cohorts of 12 Black Angus steers were housed in climate-controlled rooms (CCR) and subjected to three thermal …
View article: Analysis of the Synergistic Effect of Endophytic Bacteria and Metabolites on Yield in Soybean Roots Under Biochar with Nitrogen Fertilization
Analysis of the Synergistic Effect of Endophytic Bacteria and Metabolites on Yield in Soybean Roots Under Biochar with Nitrogen Fertilization Open
The appropriate application of nitrogen fertilizers and biochar to the soil is beneficial for soybean growth, and a combination of biochar and nitrogen can improve low-nitrogen fertilizer utilization efficiency. However, the effect of the …
View article: HCAR2 Modulates the Crosstalk between Mammary Epithelial Cells and Macrophages to Mitigate <i>Staphylococcus aureus</i> Infection in the Mouse Mammary Gland
HCAR2 Modulates the Crosstalk between Mammary Epithelial Cells and Macrophages to Mitigate <i>Staphylococcus aureus</i> Infection in the Mouse Mammary Gland Open
Staphylococcus aureus ( S. aureus ) is a major zoonotic pathogen, with mammary gland infections contributing to mastitis, a condition that poses significant health risks to lactating women and adversely affects the dairy industry. Therefor…
View article: Protective Role of Oligochitosan in Intestinal Homeostasis to Edwardsiella Ictaluri in Hybrid Grouper
Protective Role of Oligochitosan in Intestinal Homeostasis to Edwardsiella Ictaluri in Hybrid Grouper Open
View article: In-Depth Analysis of the Characteristics of Volatile Organic Compounds in Wines: A Systematic Study Integrating Intelligent Sensory and Metabolomics Techniques with Chemometrics and Machine Learning Models
In-Depth Analysis of the Characteristics of Volatile Organic Compounds in Wines: A Systematic Study Integrating Intelligent Sensory and Metabolomics Techniques with Chemometrics and Machine Learning Models Open
View article: CircCSPP1 Competitively Binds miR-10a to Regulate BMP7 Expression and Affects the Proliferation of Dermal Papilla Cells
CircCSPP1 Competitively Binds miR-10a to Regulate BMP7 Expression and Affects the Proliferation of Dermal Papilla Cells Open
A series of differentially expressed circular RNAs (circRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs) were identified through sequencing in the hair follicle tissues of Hu sheep with small-waved and straight wool patterns. Based on…
View article: Prolonged moderate to vigorous physical activity may lead to a decline in cognitive performance: a Mendelian randomization study
Prolonged moderate to vigorous physical activity may lead to a decline in cognitive performance: a Mendelian randomization study Open
Objective This study investigates the causal relationship between moderate to vigorous physical activity and cognitive performance. Methods Genetic loci strongly related to moderate to vigorous physical activity from genome-wide associatio…
View article: MicroRNA-181a Targets GNAI2 and Affects the Proliferation and Induction Ability of Dermal Papilla Cells: The Potential Involvement of the Wnt/β-Catenin Signaling Pathway
MicroRNA-181a Targets GNAI2 and Affects the Proliferation and Induction Ability of Dermal Papilla Cells: The Potential Involvement of the Wnt/β-Catenin Signaling Pathway Open
Wool is generated by hair follicles (HFs), which are crucial in defining the length, diameter, and morphology of wool fibers. However, the regulatory mechanism of HF growth and development remains largely unknown. Dermal papilla cells (DPC…
View article: Exploring the relationship among soccer-related knowledge, attitude, practice, and self-health in Chinese campus soccer education
Exploring the relationship among soccer-related knowledge, attitude, practice, and self-health in Chinese campus soccer education Open
View article: FecB Was Associated with Litter Size and Follows Mendel’s Laws of Inheritance When It Transited to Next Generation in Suhu Meat Sheep Breeding Population
FecB Was Associated with Litter Size and Follows Mendel’s Laws of Inheritance When It Transited to Next Generation in Suhu Meat Sheep Breeding Population Open
In order to investigate the effect of FecB on litter size and growth and development traits of Suhu meat sheep and the inheritance patterns of FecB between parents and offspring in the population. In this experiment, 2241 sheep from the Su…
View article: 45O First-in-human study of ABSK061: A selective fibroblast growth factor receptor (FGFR) 2/3 inhibitor for treating patients with advanced solid tumors
45O First-in-human study of ABSK061: A selective fibroblast growth factor receptor (FGFR) 2/3 inhibitor for treating patients with advanced solid tumors Open
Aberrant activation of FGFR signaling promotes cancer cell proliferation and tumor growth. Targeting FGFR2/3 selectively may alleviate FGFR1-dependent hyperphosphatemia and could provide better efficacy. Here, we evaluated the safety and p…
View article: SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene
SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene Open
Previous studies have demonstrated that CUX1 could contribute to the proliferation of DPCs in vitro, but the upstream transcriptional regulatory mechanisms of CUX1 remain largely unknown. This study aimed to investigate the upstream transc…
View article: [Resveratrol alleviates hyperglycemia-induced cardiomyocyte hypertrophy by maintaining mitochondrial homeostasis <i>via</i> enhancing SIRT1 expression].
[Resveratrol alleviates hyperglycemia-induced cardiomyocyte hypertrophy by maintaining mitochondrial homeostasis <i>via</i> enhancing SIRT1 expression]. Open
Resveratrol inhibits hyperglycemia-induced cardiomyocyte hypertrophy by reducing oxidative stress, the mechanisms of which involve enhancement of SIRT1 protein expression, regulation of mitochondrial fusion and division balance, and promot…
View article: Allostasis as a consequence of high heat load in grain-fed feedlot cattle
Allostasis as a consequence of high heat load in grain-fed feedlot cattle Open
Heat wave intensity, frequency, and duration are increasing in many regions of the world, including locations where highly productive livestock are raised. There are animal health and welfare, as well as economic impacts from these events.…
View article: Comparing the responses of grain-fed feedlot cattle under moderate heat load and during subsequent recovery with those of feed-restricted thermoneutral counterparts: blood cells and inflammatory markers
Comparing the responses of grain-fed feedlot cattle under moderate heat load and during subsequent recovery with those of feed-restricted thermoneutral counterparts: blood cells and inflammatory markers Open
Given the climate projections for livestock rearing regions globally, understanding the inflammatory status of livestock under various heat loads will be informative to animal welfare and management. A survey of plasma inflammatory markers…
View article: A novel transcriptomic signature associated with lymphovascular invasion predicts clinical outcomes, tumor microenvironment, and therapeutic response in lung adenocarcinoma
A novel transcriptomic signature associated with lymphovascular invasion predicts clinical outcomes, tumor microenvironment, and therapeutic response in lung adenocarcinoma Open
The LVRS established in this study serves as a valid tool to predict the prognosis and recurrence status of lung adenocarcinoma patients and has a predictive effect on the response to postoperative treatment. The establishment of LVRS may …
View article: Wagyu Feeder Check: A genomic-based tool to identify performance differences of Australian Wagyu and Wagyu crossed cattle
Wagyu Feeder Check: A genomic-based tool to identify performance differences of Australian Wagyu and Wagyu crossed cattle Open
Context Wagyu Feeder Check is a genomic-based tool designed to provide genomic estimated breeding values (GEBV) for five feedlot growth and carcase traits. At present, Wagyu Feeder Check is based on a reference population of 8316 genotyped…
View article: SOX18 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Signaling Pathway
SOX18 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Signaling Pathway Open
SRY-box transcription factor 18 (SOX18) is known to play a crucial role in the growth and development of hair follicles (HF) in both humans and mice. However, the specific effect of SOX18 on sheep hair follicles remains largely unknown. In…
View article: Using SHAP to analyze technical and tactical performance in table tennis based on hybrid Catboost-TPE with four-phase evaluation theory
Using SHAP to analyze technical and tactical performance in table tennis based on hybrid Catboost-TPE with four-phase evaluation theory Open
This study adopted a novel algorithm, SHapley Additive exPlanation (SHAP), to analyze the table tennis matches based on a hybrid gradient boosting + categorical features-tree-structured parzen estimator (Catboost-TPE) with the four-phase e…
View article: Non-linear association of atherogenic index of plasma with hyperuricemia in US adults: a cross- sectional study
Non-linear association of atherogenic index of plasma with hyperuricemia in US adults: a cross- sectional study Open
Background Hyperuricemia is related to various cardiometabolic diseases in US adults, having an increasingly substantial impact on healthcare resources and costs. Nonetheless, there are limited studies examining the association between ath…
View article: Association between DNA Methylation in the Core Promoter Region of the CUT-like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep
Association between DNA Methylation in the Core Promoter Region of the CUT-like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep Open
CUT-like homeobox 1 (CUX1) has been proven to be a key regulator in sheep hair follicle development. In our previous study, CUX1 was identified as a differential expressed gene between Hu sheep lambskin with small wave patterns (SM) and st…