Yu Kong
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View article: Recent advances in transition-metal-free arylation by using diaryliodonium salts
Recent advances in transition-metal-free arylation by using diaryliodonium salts Open
View article: Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset <scp>LGI1</scp>‐Antibody Encephalitis
Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset <span>LGI1</span>‐Antibody Encephalitis Open
Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of ea…
View article: Cardiac toxicity and intervention strategies during thoracic cancer radiotherapy
Cardiac toxicity and intervention strategies during thoracic cancer radiotherapy Open
Radiation-induced heart disease (RIHD) represents a major dose-limiting complication of thoracic radiotherapy, with a multifaceted pathogenesis involving endothelial dysfunction, chronic oxidative stress, and progressive fibrotic remodelin…
View article: The impact of polyethylene terephthalate microplastics on the pathogenesis of atherosclerosis: Focusing on network toxicology and target gene detection
The impact of polyethylene terephthalate microplastics on the pathogenesis of atherosclerosis: Focusing on network toxicology and target gene detection Open
This study employed a network toxicology strategy to elucidate the toxic mechanisms of polyethylene terephthalate microplastics (PET-MPs) on atherosclerosis (AS). AS is a chronic inflammatory vascular disease that may be aggravated by PET-…
View article: Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species
Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species Open
The Corydalis genus, one of the largest within the Papaveraceae family, holds a rich diversity of medicinal resources, particularly among its tuberous species. Benzylisoquinoline alkaloids (BIAs) are primarily responsible for the medicinal…
View article: RabE1a‐ and SEC10b‐mediated exocytosis and AP2β‐mediated endocytosis are involved in the intracellular transport of tobamoviruses
RabE1a‐ and SEC10b‐mediated exocytosis and AP2β‐mediated endocytosis are involved in the intracellular transport of tobamoviruses Open
Summary To establish systemic infection, plant viruses must replicate, and conduct intra‐ and intercellular movement and long‐distance movement, all of which require the participation of host factors. Tobamoviruses move in the form of move…
View article: Genome-wide pleiotropy analysis reveals shared architecture between renal traits and gastrointestinal tract diseases
Genome-wide pleiotropy analysis reveals shared architecture between renal traits and gastrointestinal tract diseases Open
Background: Comorbidities between gastrointestinal tract (GIT) and renal diseases have been widely reported, but the shared genetic architecture of gut and renal traits remains unclear. Objective: To investigate the shared genetic etiology…
View article: Reconfigured metabolism brain network in asymptomatic Creutzfeldt-Jakob disease
Reconfigured metabolism brain network in asymptomatic Creutzfeldt-Jakob disease Open
This study revealed altered brain metabolic topology and connectomics in asymptomatic PRNP G114V mutation carriers, which could be detected before gray matter or regional metabolic changes, suggesting that metabolism topology reconfigurati…
View article: Characterization of three flavonol synthases involved in the biosynthesis of 4'-deoxyflavonol in <i>Scutellaria baicalensis</i> Georgi
Characterization of three flavonol synthases involved in the biosynthesis of 4'-deoxyflavonol in <i>Scutellaria baicalensis</i> Georgi Open
View article: Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay Open
Unintentional, early pregnancy alcohol consumption affects embryonic development. During the peri-implantation stage, coinciding with the transition from naive to primed pluripotency, the long isoform of KDM2B (KDM2BLF) underlies the de no…
View article: Identification of common and specific cold resistance pathways from cold tolerant and non-cold tolerant mango varieties
Identification of common and specific cold resistance pathways from cold tolerant and non-cold tolerant mango varieties Open
Mango has frequently encountered severe climate and environmental challenges such as low temperatures, seriously affecting the sustainable development of the industry. In the study, physiological measurements showed that the activities of …
View article: Clinical features of COVID-19-related encephalitis: comparison with the features of herpes virus encephalitis and autoimmune encephalitis
Clinical features of COVID-19-related encephalitis: comparison with the features of herpes virus encephalitis and autoimmune encephalitis Open
Introduction Identifying coronavirus disease 2019 (COVID-19)-related encephalitis without clear etiological evidence is clinically challenging. The distinctions between this condition and other prevalent encephalitis types remain unknown. …
View article: Cold-stress induced metabolomic and transcriptomic changes in leaves of three mango varieties with different cold tolerance
Cold-stress induced metabolomic and transcriptomic changes in leaves of three mango varieties with different cold tolerance Open
Background Mango ( Mangifera indica L.) is grown in Hainan, Guangdong, Yunnan, Sichuan, and Fujian provinces and Guanxi autonomous region of China. However, trees growing in these areas suffer severe cold stress during winter, which affect…
View article: Genetic and pathological features encipher the phenotypic heterogeneity of Gerstmann-Sträussler-Scheinker disease
Genetic and pathological features encipher the phenotypic heterogeneity of Gerstmann-Sträussler-Scheinker disease Open
This study reveals GSS's intricate nature, showing significant variations in clinical presentations, diagnostic findings, and pathological features. Mutation sites and pathological changes play crucial roles in determining the GSS clinical…
View article: A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles Open
N(6)-methyladenosine (m6A) critically regulates RNA dynamics in various biological processes. The m6A demethylase ALKBH5 promotes tumorigenesis of glioblastoma, while the intricate web that orchestrates its regulation…
View article: Production of species-specific anthocyanins through an inducible system in plant hairy roots
Production of species-specific anthocyanins through an inducible system in plant hairy roots Open
Anthocyanins are widely distributed pigments in flowering plants with red, purple or blue colours. Their properties in promoting heath make anthocyanins perfect natural colourants for food additives. However, anthocyanins with strong colou…
View article: Gap-free genome assembly and<i>CYP450</i>gene family analysis reveal the biosynthesis of anthocyanins in<i>Scutellaria baicalensis</i>
Gap-free genome assembly and<i>CYP450</i>gene family analysis reveal the biosynthesis of anthocyanins in<i>Scutellaria baicalensis</i> Open
Scutellaria baicalensis Georgi, a member of the Lamiaceae family, is a widely utilized medicinal plant. The flavones extracted from S. baicalensis contribute to numerous health benefits, including anti-inflammatory, antiviral, and anti-tum…
View article: Correction: Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia
Correction: Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia Open
Following the publication of the original article,1 an error has been identified in Table 2 by the authors. This error was inadvertently introduced during the proofreading process. While changing the original short hyphens ("-") to long hy…
View article: Fecal microbiota transplantation inhibited neuroinflammation of traumatic brain injury in mice via regulating the gut–brain axis
Fecal microbiota transplantation inhibited neuroinflammation of traumatic brain injury in mice via regulating the gut–brain axis Open
Introduction Recent studies have highlighted the vital role of gut microbiota in traumatic brain injury (TBI). Fecal microbiota transplantation (FMT) is an effective means of regulating the microbiota–gut–brain axis, while the beneficial e…
View article: Application of the mild behavioral impairment checklist in Chinese patients with the behavioral variant of frontotemporal dementia
Application of the mild behavioral impairment checklist in Chinese patients with the behavioral variant of frontotemporal dementia Open
View article: Toward an early clinical diagnosis of <scp>MM2</scp>‐type sporadic <scp>Creutzfeldt–Jakob</scp> disease
Toward an early clinical diagnosis of <span>MM2</span>‐type sporadic <span>Creutzfeldt–Jakob</span> disease Open
Objective To assess the proportion of clinically diagnosed MM2‐type sporadic Creutzfeldt–Jakob disease (sCJD) in a Chinese cohort, describe the clinical features of MM2‐cortical (MM2C) and MM2‐thalamic (MM2T) type sCJD to improve the early…
View article: Erythrocyte indices in creutzfeldt–jakob disease predict survival time
Erythrocyte indices in creutzfeldt–jakob disease predict survival time Open
Background Creutzfeldt–Jakob disease (CJD) is a devastating neurodegenerative disease caused by propagation of abnormally folded prion proteins (PrP Sc ). Some fluid biomarkers have been reported to be associated with disease duration in C…
View article: Genetic prion diseases presenting as frontotemporal lobar degeneration: clinical features and diagnostic challenge
Genetic prion diseases presenting as frontotemporal lobar degeneration: clinical features and diagnostic challenge Open
Background Elucidate the clinical and ancillary feature of genetic prion diseases (gPrDs) presenting with frontotemporal lobar degeneration (FTLD) in order to aid early identification, diagnosis, and referral for genotype testing. Method G…
View article: Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia
Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia Open
Objectives Glymphatic function has not yet been explored in behavioral variant frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic function and bvFTD remains unknown. Method A total of 74 patients with bvFT…
View article: Clinical and Genetic Characteristics of the Heidenhain Variant of Creutzfeldt–Jakob Disease
Clinical and Genetic Characteristics of the Heidenhain Variant of Creutzfeldt–Jakob Disease Open
Background: The Heidenhain variant of Creutzfeldt–Jakob disease (HvCJD), as a rare phenotype of CJD, has been under-recognized. We aim to elucidate the clinical and genetic features of HvCJD and investigate the differences of clinical feat…
View article: Neutrophil to High-density Lipoprotein ratio (NHR) as a potential predictor of disease severity and survival time in Creutzfeldt-Jakob disease
Neutrophil to High-density Lipoprotein ratio (NHR) as a potential predictor of disease severity and survival time in Creutzfeldt-Jakob disease Open
Introduction Creutzfeldt-Jakob disease (CJD) is a fatal and irreversible neurodegenerative disease. Identification of inexpensive and easy-to-implement biomarkers of CJD which could predict disease severity and patient survival is importan…
View article: Altered metabolic connectivity within the limbic cortico-striato-thalamo-cortical circuit in presymptomatic and symptomatic behavioral variant frontotemporal dementia
Altered metabolic connectivity within the limbic cortico-striato-thalamo-cortical circuit in presymptomatic and symptomatic behavioral variant frontotemporal dementia Open
View article: Cation-Π Mechanism Promotes the Adsorption of Humic Acid on Polystyrene Nanoplastics: Evidence from Experimental Characterization and Dft Calculation
Cation-Π Mechanism Promotes the Adsorption of Humic Acid on Polystyrene Nanoplastics: Evidence from Experimental Characterization and Dft Calculation Open
View article: Modified percutaneous iliosacral screw and anterior internal fixator technique for treating unstable pelvic fractures: a retrospective study
Modified percutaneous iliosacral screw and anterior internal fixator technique for treating unstable pelvic fractures: a retrospective study Open
View article: Naturally occurring Alzheimer’s disease in rhesus monkeys
Naturally occurring Alzheimer’s disease in rhesus monkeys Open
Alzheimer’s disease (AD) is the most common neurodegenerative disease. To date, its cause is unclear and there are no effective treatments or preventive measures. Despite there are accumulating evidences for the existence of AD pathologica…