Explanipedia

The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels Open

Yongyan Song, Youjin Zhang, Xinyu Liu, Gong Wang, Yuhang Ai , et al. · 2025

Background The associations between the rs7799039 variant in the promoter region of the leptin gene ( LEP ) and the rs1137100, rs1137101, and rs1805094 variants in the exons of the leptin receptor gene ( LEPR ) with leptin levels and gluco…

Generalized Frobenius Manifold Structures on the Orbit Spaces of Affine Weyl Groups I Open

Lingrui Jiang, Siqi Liu, Yingchao Tian, Youjin Zhang · 2025

We present an approach to construct a class of generalized Frobenius manifold structures on the orbit spaces of affine Weyl groups, and prove that their monodromy groups are proper subgroups of the associated affine Weyl groups.

Associations Between APOC3 and ANGPTL8 Gene Polymorphisms With MASLD Risk and the Mediation Effect of Triglyceride on MASLD in the Chinese Population Open

Jia Bao Pan, Xue Wang, Youjin Zhang, Ting Wang, Saiqun Lv , et al. · 2025

Apolipoprotein C3 ( APOC3 ) and angiopoietin‐like protein 8 ( ANGPTL 8) genes are related to lipid metabolism. The relationships between single nucleotide polymorphisms (SNPs) in the APOC3 and ANGPTL 8 genes with metabolic dysfunction‐asso…

Legendre transformations of a class of generalized Frobenius manifolds and the associated integrable hierarchies Open

Siqi Liu, Haonan Qu, Youjin Zhang · 2024

For two generalized Frobenius manifolds related by a Legendre-type transformation, we show that the associated integrable hierarchies of hydrodynamic type, which are called the Legendre-extended Principal Hierarchies, are related by a cert…

Fast and accurate DNASeq variant calling workflow composed of LUSH toolkit Open

Taifu Wang, Youjin Zhang, Haoling Wang, Qiwen Zheng, Jiaobo Yang , et al. · 2024

These findings suggest that the LUSH pipeline is a highly promising alternative to the GATK pipeline for WGS data analysis, with the potential to significantly improve bedside analysis of acutely ill patients, large-scale cohort data analy…

Lipid-lowering effect of Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections: A Systematic Review and Meta-Analysis of Controlled Clinical Trials Open

Youjin Zhang, Jin Kuk Yang, Qianyin Pang, Zhimin Lv, Dan Zhu , et al. · 2024

Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections, four traditional Chinese medicine prescriptions, have been widely explored regarding their lipid-lowering property, but the findings were inconsistent and inconclusive. This me…

The extended Ablowitz-Ladik hierarchy and a generalized Frobenius manifold Open

Siqi Liu, Yuewei Wang, Youjin Zhang · 2024

We define a certain extension of the Ablowitz-Ladik hierarchy, and prove that this extended integrable hierarchy coincides with the topological deformation of the Principal Hierarchy of a generalized Frobenius manifold with non-flat unity.

Solutions of the loop equations of a class of generalized Frobenius manifolds Open

Siqi Liu, Haonan Qu, Yuewei Wang, Youjin Zhang · 2024

We prove the existence and uniqueness of solution of the loop equation associated with a semisimple generalized Frobenius manifold with non-flat unity, and show, for a particular example of one dimensional generalized Frobenius manifold, t…

Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population Open

Xue Wang, Haiyan Nie, Mi Su, Yang Wu, Qianyin Pang , et al. · 2024

The relationships of serum circNIPSNAP3A and circHIPK3 with metabolic disorders, atherosclerosis and severity of coronary artery disease (CAD) remain to be clarified. Three hundred and thirty-eight subjects were categorized into normal cor…

Minor alleles of FTO rs9939609 and rs17817449 polymorphisms confer a higher risk of type 2 diabetes mellitus and dyslipidemia, but not coronary artery disease in a Chinese Han population Open

Youjin Zhang, Lvlin Chen, Junchen Zhu, Hao Liu, Luying Xu , et al. · 2023

Background Relationships of the polymorphisms in fat mass and obesity-associated gene ( FTO ) and peroxisome proliferator-activated receptor delta gene ( PPARD ) with metabolic-related diseases remain to be clarified. Methods One thousand …

Hydrocarbon generation differences of shales composed of green algal and cyanobacteria: A case study of Mesozoic and Cenozoic saline lacustrine shales in Junggar Basin, NW China Open

Miao Yu, Gang Gao, Wanyun Ma, Miao Liu, Ni Zhou , et al. · 2023

The Mesozoic and Cenozoic strata in the Junggar basin developed two sets of shallow to semi-deep lacustrine shale, namely, the Cretaceous Qingshuihe Formation (K1q) and the Paleogene Anjihaihe Formation (E2-3a). Through organic petrology a…

The rs17782313 polymorphism near MC4R gene confers a high risk of obesity and hyperglycemia, while PGC1α rs8192678 polymorphism is weakly correlated with glucometabolic disorder: a systematic review and meta-analysis Open

Youjin Zhang, Shiyun Li, Haiyan Nie, Xue Wang, Xuanxuan Li , et al. · 2023

Background The relationships of the rs17782313 polymorphism near melanocortin 4 receptor gene (MC4R) and the rs8192678 polymorphism in peroxisome proliferator-activated receptor gamma coactivator 1 alpha gene (PGC1α) with metabolic abnorma…

Widely Targeted Volatilomics and Metabolomics Analysis Reveal the Metabolic Composition and Diversity of Zingiberaceae Plants Open

Youjin Zhang, Rongxiu Su, Honglun Yuan, Haihong Zhou, Yiding Jiangfang , et al. · 2023

Zingiberaceae plants are widely used in the food and pharmaceutical industries; however, research on the chemical composition and interspecific differences in the metabolome and volatilome of Zingiberaceae plants is still limited. In this …

Variational Bihamiltonian Cohomologies and Integrable Hierarchies III: Linear Reciprocal Transformations Open

Siqi Liu, Zhe Wang, Youjin Zhang · 2023

For an integrable hierarchy which possesses a bihamiltonian structure with semisimple hydrodynamic limit, we prove that the linear reciprocal transformation with respect to any of its symmetry transforms it to another bihamiltonian integra…

Fast and accurate DNASeq Variant Calling workflow composed of LUSH toolkit Open

Taifu Wang, Youjin Zhang, Haoling Wang, Qiwen Zheng, Jiaobo Yang , et al. · 2023

Background Whole genome sequencing (WGS) is becoming increasingly prevalent for molecular diagnosis, staging and prognosis because of its declining costs and the ability to detect nearly all genes associated with a patient’s disease. The c…

Identification of Key Aromatic Compounds in Basil (Ocimum L.) Using Sensory Evaluation, Metabolomics and Volatilomics Analysis Open

Pengmeng Du, Honglun Yuan, Yayu Chen, Haihong Zhou, Youjin Zhang , et al. · 2023

Basil (Ocimum L.) is widely used as a flavor ingredient, however research on basil flavor is limited. In the current study, nine basil species were selected, including Ocimum basilicum L.var. pilosum (Willd.) Benth., Ocimum sanctum, Ocimum…

Generalized Frobenius Manifolds with Non-flat Unity and Integrable Hierarchies Open

Siqi Liu, Haonan Qu, Youjin Zhang · 2022

For any generalized Frobenius manifold with non-flat unity, we construct a bihamiltonian integrable hierarchy of hydrodynamic type which is an analogue of the Principal Hierarchy of a Frobenius manifold. We show that such an integrable hie…

Variational Bihamiltonian Cohomologies and Integrable Hierarchies II: Virasoro Symmetries Open

Siqi Liu, Zhe Wang, Youjin Zhang · 2022

Reduction of the 2D Toda Hierarchy and Linear Hodge Integrals Open

Siqi Liu, Zhe Wang, Youjin Zhang · 2022

We construct a certain reduction of the 2D Toda hierarchy and obtain a tau-symmetric Hamiltonian integrable hierarchy. This reduced integrable hierarchy controls the linear Hodge integrals in the way that one part of its flows yields the i…

On Equivariant Gromov--Witten Invariants of Resolved Conifold with Diagonal and Anti-Diagonal Actions Open

Siqi Liu, Di Yang, Youjin Zhang, Chun Hui Zhou · 2022

We propose two conjectural relationships between the equivariant Gromov-Witten invariants of the resolved conifold under diagonal and anti-diagonal actions and the Gromov-Witten invariants of $\mathbb{P}^1$, and verify their validity in ge…

Tri-Hamiltonian structure of the Ablowitz–Ladik hierarchy Open

Shuangxing Li, Siqi Liu, Haonan Qu, Youjin Zhang · 2022

Total Glucosides of Paeony Attenuates Ulcerative Colitis via Inhibiting TLR4/NF-κB Signaling Pathway Open

Junying Xiang, Renwei Hu, Qunhua Li, Youjin Zhang, Shujin Li , et al. · 2022

The therapeutic effects and mechanisms of action of total glucosides of paeony (TGP) in treating ulcerative colitis remain to be clarified. Mouse model of ulcerative colitis was treated with TGP and the indexes including scores of disease …

The Virasoro-like Algebra of a Frobenius Manifold Open

Siqi Liu, Di Yang, Youjin Zhang, Jian Zhou · 2021

For an arbitrary calibrated Frobenius manifold, we construct an infinite dimensional Lie algebra, called the Virasoro-like algebra, which is a deformation of the Virasoro algebra of the Frobenius manifold. By using the Virasoro-like algebr…

Development of a widely targeted volatilomics method for profiling volatilomes in plants Open

Honglun Yuan, Guangping Cao, Xiaodong Hou, Menglan Huang, Pengmeng Du , et al. · 2021

Linearization of Virasoro symmetries associated with semisimple Frobenius manifolds Open

Siqi Liu, Zhe Wang, Youjin Zhang · 2021

For any semisimple Frobenius manifold, we prove that a tau-symmetric bihamiltonian deformation of its Principal Hierarchy admits an infinite family of linearizable Virasoro symmetries if and only if all the central invariants of the corres…

Super tau-covers of bihamiltonian integrable hierarchies Open

Siqi Liu, Zhe Wang, Youjin Zhang · 2021

Variational Bihamiltonian Cohomologies and Integrable Hierarchies I: Foundations Open

Siqi Liu, Zhe Wang, Youjin Zhang · 2021

This series of papers is devoted to the study of deformations of Virasoro symmetries of the principal hierarchies associated to semisimple Frobenius manifolds. The main tool we use is a generalization of the bihamiltonian cohomology called…

Masur--Veech volumes of quadratic differentials and their asymptotics Open

Di Yang, Don Zagier, Youjin Zhang · 2020

Based on the Chen--Möller--Sauvaget formula, we apply the theory of integrable systems to derive three equations for the generating series of the Masur--Veech volumes ${\rm Vol} \, \mathcal{Q}_{g,n}$ associated with the principal strata of…

Drinfeld–Sokolov Hierarchies and Diagram Automorphisms of Affine Kac–Moody Algebras Open

Siqi Liu, Chao‐Zhong Wu, Youjin Zhang, Xu Zhou · 2019

Virasoro Constraints for Drinfeld-Sokolov hierarchies and equations of Painlevé type Open

Siqi Liu, Chaozhong Wu, Youjin Zhang · 2019

We construct a tau cover of the generalized Drinfeld-Sokolov hierarchy associated to an arbitrary affine Kac-Moody algebra with gradations $\mathrm{s}\le\mathds{1}$ and derive its Virasoro symmetries. By imposing the Virasoro constraints w…

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