Explanipedia

Helicobacter pylori antimicrobial resistance and gene variants in Shandong Province Open

Zhijing Xue, Qi Zhao, Fengyan Pei, Yanan Gong, Fang Wang , et al. · 2025

The emergence of antibiotic resistance in Helicobacter pylori led to a sharp decline in eradication rates, but there are limited data regarding the prevalence and genetic mechanisms of antibiotic resistance in Shandong. This study aims to …

Ultrasonographic features and clinical management of IgG4-related submandibular gland inflammation: a case report Open

Wenhui Zhang, Nan Pang, Xu Wang, Peng Fang, Youjun Wang , et al. · 2025

IgG4-related submandibular gland inflammation (IgG4-RSGI) is an immunologically mediated condition characterized by chronic fibroinflammatory lesions and elevated serum IgG4 levels. It often lacks specific clinical and imaging features, le…

ER-PM tether Syt1 limits cell-to-cell connectivity via plasmodesmata during innate immune responses in Arabidopsis Open

Jiajing Li, Pengfei Lu, Qing Pan, Bingxiao Wang, Youjun Wang , et al. · 2025

Upon perception of microbe-associated molecular patterns (MAMPs), plants close plasmodesmata (PD) as part of their innate immune responses. However, the signaling cascades and molecular mechanisms underlying MAMP-induced PD closure require…

Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells Open

Wenjia Gu, Jiahui Chen, Yiyin Zhang, Zhirong Wang, Jia Li , et al. · 2025

GPAT4 sustains endoplasmic reticulum homeostasis in endocardial cells and safeguards heart development Open

Tingting Zhao, Kunlin Jin, Xiaodong Wang, Xiong Su, Youjun Wang , et al. · 2025

The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic…

Preferential allosteric modulation of Otop1 channels by small molecule compounds Open

Xiangjin Kong, Jie Sun, Honggang Zhang, Yuan Yin, Xinyao Liang , et al. · 2025

TP53I11 Functions Downstream of Multiple MicroRNAs to Increase ER Calcium Levels and Inhibits Cancer Cell Proliferation Open

Yiping Wang, Shuai Zhang, Jie Bing, Wanjie Li, Lin Sun , et al. · 2024

Cells meticulously regulate free calcium ion (Ca2+) concentrations, with the endoplasmic reticulum (ER) being crucial for Ca2+ homeostasis. Disruptions in ER Ca2+ balance can contribute to various diseases, including cancer. Although consi…

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia Open

Xiaoyu Tian, Hanyu Wang, Song Liu, Wei Liu, Kaiyue Zhang , et al. · 2024

Production of melanin pigments is a protective mechanism of the skin against ultraviolet (UV)-induced damage and carcinogenesis. However, the molecular basis for melanogenesis is still poorly understood. Herein, we demonstrate a critical i…

Calcium Homeostasis Is Involved in the Modulation of Gene Expression by MSL2 in Imbalanced Genomes Open

Ruixue Wang, Shuai Zhang, Haizhu Qi, Liuqing Wang, Youjun Wang , et al. · 2024

Aneuploidy is highly detrimental to organisms due to genomic imbalance. However, the influence of parental unbalanced genome conditions on gene expression of their offspring remains unclear, particularly in animals. To further explore the …

STIM1 functions as a proton sensor to coordinate cytosolic pH with store-operated calcium entry Open

Yilan Chen, Panpan Liu, Ziyi Zhong, Hanhan Zhang, Aomin Sun , et al. · 2024

Virulence gene polymorphisms in Shandong Helicobacter pylori strains and their relevance to gastric cancer Open

Zhijing Xue, Weijia Li, Hailing Ding, Fengyan Pei, Jianzhong Zhang , et al. · 2024

Background Helicobacter pylori ( H . pylori ) virulence factors, particularly the cagA and vacA genotypes, play important roles in the pathogenic process of gastrointestinal disease. Methods The cagA and vacA genotypes of 87 H . pylori str…

Redox Enzymes P4HB and PDIA3 Interact with STIM1 to Fine-Tune Its Calcium Sensitivity and Activation Open

Yangchun Du, Feifan Wang, Panpan Liu, Sisi Zheng, Jia Li , et al. · 2024

Sensing the lowering of endoplasmic reticulum (ER) calcium (Ca2+), STIM1 mediates a ubiquitous Ca2+ influx process called the store-operated Ca2+ entry (SOCE). Dysregulated STIM1 function or abnormal SOCE is strongly associated with autoim…

Identification of Glucosidase II that regulates STIM1 activation dynamics Open

Yangchun Du, Sisi Zheng, Feifan Wang, Jia Li, Xiaoman Yuan , et al. · 2024

The ubiquitous presence of stromal interaction molecule (STIM), endoplasmic reticulum (ER) Ca 2+ sensors, plays a crucial role for maintaining Ca 2+ homeostasis and signaling in mammalian cells by linking ER Ca 2+ depletion with extracellu…

Genetically encoded calcium indicators for organelles Open

Wenjia Gu, Ziyi Zhong, Hanhan Zhang, Xiaoyan Zhang, Youjun Wang · 2024

真核细胞中的内质网、线粒体等含钙细胞器,是细胞钙信号系统的重要组成部分。揭示这些细胞器中的钙离子动态及稳态有着重要的生理和病理意义。与化学钙探针相比,细胞器特异性表达的基因编码的钙指示剂(Genetically Encoded Ca²⁺ Indicator,GECI)的定位更准确,使用更简便,因而具有很广阔的应用前景。本综述系统梳理了现有的线粒体、内质网、高尔基体、细胞内囊泡以及溶酶体等几种细胞器GECI的研究进展。总结了现有工具的优缺点,展望有待进一…

Highly Dynamic and Sensitive NEMOer Calcium Indicators for Imaging ER Calcium Signals in Excitable Cells Open

Wenjia Gu, Jiahui Chen, Yiyin Zhang, Zhirong Wang, Jia Li , et al. · 2024

Endoplasmic/sarcoplasmic reticulum (ER/SR) sits at the heart of the calcium (Ca 2+ ) signaling machinery, yet current genetically encoded Ca 2+ indicators (GECIs) lack the ability to detect elementary Ca 2+ release events from ER/SR, parti…

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER Ca<sup>2+</sup>homeostasis involved in neuronal differentiation Open

Liuqing Wang, Jia Li, Yiping Wang, Ziyi Zhong, Yuqing Wang , et al. · 2024

Endoplasmic reticulum (ER) calcium (Ca 2+ ) homeostasis is essential for maintaining normal cellular physiological functions. Its disturbance is strongly linked to the onset and progression of human diseases, including cancer, developmenta…

A bright cyan fluorescence calcium indicator for mitochondrial calcium with minimal interference from physiological pH fluctuations Open

Wenjia Gu, Yuqin Yang, Yuqing Wang, Jia Li, Wanjie Li , et al. · 2024

Genetically Encoded Calcium (Ca²⁺) indicators (GECIs) are indispensable tools for dissecting intracellular Ca²⁺ signaling and monitoring cellular activities. Mitochondrion acts as a Ca²⁺ sink and a central …

An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1 Open

Yandong Zhou, Michelle R. Jennette, Guolin Ma, Sarah A. Kazzaz, James H. Baraniak , et al. · 2023

Ca 2+ signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-Hi…

Finding NEMO: The quest for next‐generation genetically encoded calcium indicators Open

Wenjia Gu, Jia Li, Yuepeng Ke, Yubin Zhou, Youjun Wang · 2023

Calcium ion (Ca2+) serves as a ubiquitous second messenger within eukaryotic cells. Alterations in free Ca2+ concentration, known as Ca2+ signals,1 play a vital role in regulating a wide array of physiological and pathological processes, i…

Role of STIM1 in the Regulation of Cardiac Energy Substrate Preference Open

Panpan Liu, Zhuli Yang, Youjun Wang, Aomin Sun · 2023

The heart requires a variety of energy substrates to maintain proper contractile function. Glucose and long-chain fatty acids (FA) are the major cardiac metabolic substrates under physiological conditions. Upon stress, a shift of cardiac s…

Magnetic and grain-size properties of the Weihe River sediments reveal runoff changes in the Holocene Open

Junhui Zhang, Dongxing Li, Yaxin Wang, Xin Liu, Bowen Wu , et al. · 2023

Detailed and systematic analyses of the magnetic and grain-size properties of the Weihe River sediments were conducted to explore effective proxies that could reflect variations in the runoff. Ultimately, the magnetic parameter χARM/χlf wa…

Engineering of NEMO as calcium indicators with large dynamics and high sensitivity Open

Jia Li, Ziwei Shang, Jiahui Chen, Wenjia Gu, Li Yao , et al. · 2023

Genetically encoded calcium indicators (GECIs) are indispensable tools for real-time monitoring of intracellular calcium signals and cellular activities in living organisms. Current GECIs face the challenge of suboptimal peak signal-to-bas…

Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open