Yan Xia
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View article: Cascade Mechanochemical Transformation of a Benzobarrelane Polymer: A Neighboring Repeat Unit Effect
Cascade Mechanochemical Transformation of a Benzobarrelane Polymer: A Neighboring Repeat Unit Effect Open
Mechanical force can trigger non-destructive chemical transformations of force-responsive molecules, mechanophores, that are embedded in a long polymer chain to change or induce a variety of their physical and chemical properties. Studies …
View article: Probing Effects of Electron Addition to Polycyclic Conjugated Hydrocarbons Containing Four‐Membered Rings
Probing Effects of Electron Addition to Polycyclic Conjugated Hydrocarbons Containing Four‐Membered Rings Open
The rectangular cyclobutadiene (CBD, C 4 H 4 ) is a unique moiety for building nonbenzenoid polycyclic conjugated hydrocarbons with interesting electron‐accepting properties. Herein, the investigation on chemical reduction of several CBD‐c…
View article: Oxidation of [3]naphthylenes to cations and dications converts local paratropicity into global diatropicity
Oxidation of [3]naphthylenes to cations and dications converts local paratropicity into global diatropicity Open
Oxidized states of polycyclic aromatic hydrocarbons are of importance as they represent charged conductive species in organic semiconductor substrates. In this work, we investigated the properties of radical cations and dications of linear…
View article: Machine learning-assisted profiling of a kinked ladder polymer structure using scattering
Machine learning-assisted profiling of a kinked ladder polymer structure using scattering Open
Ladder polymers consisting of fused rings in the backbone have very limited conformational freedom, which results in very different properties from traditional linear polymers.
View article: Cross‐Linker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels
Cross‐Linker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels Open
Dynamic covalent cross‐linked (DCC) hydrogels represent a significant advance in biomaterials for regenerative medicine and mechanobiology, offering viscoelasticity, and self‐healing properties that more closely mimic in vivo tissue mechan…
View article: Effects of divalent salts on polyelectrolyte coacervation
Effects of divalent salts on polyelectrolyte coacervation Open
Polyelectrolyte solutions exhibit a demixing transition known as polyelectrolyte complexation (PEC). Recent interest in PEC has been spurred by its relevance in organizing biomolecules in intracellular environments, and by the advancement …
View article: Force Transduction Through Distant Force‐Bearing Regioisomeric Linkages Affects the Mechanochemical Reactivity of Cyclobutane
Force Transduction Through Distant Force‐Bearing Regioisomeric Linkages Affects the Mechanochemical Reactivity of Cyclobutane Open
Fundamental understanding of mechanochemical reactivity is important for designing new mechanophores. Besides the core structure of mechanophores, substituents on a mechanophore can affect its mechanochemical reactivity through electronic …
View article: Fatigue failure of soft adhesive systems: A state-of-the-art review
Fatigue failure of soft adhesive systems: A state-of-the-art review Open
Soft adhesive systems (SASs), which consist of a soft adhesive layer and/or soft adherends, have been extensively applied in advanced fields such as biomedicine, flexible electronics, and soft robotics. Understanding the fatigue failure of…
View article: Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels
Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels Open
Dynamic covalent crosslinked (DCC) hydrogels represent a significant advance in biomaterials for regenerative medicine and mechanobiology. These gels typically offer viscoelasticity and self-healing properties that more closely mimic in vi…
View article: Accurate Determination of Reactivity Ratios for Copolymerization Reactions with Reversible Propagation Mechanisms
Accurate Determination of Reactivity Ratios for Copolymerization Reactions with Reversible Propagation Mechanisms Open
An understanding of monomer sequence is required to predict and engineer the properties of copolymers. Typically, comonomer sequence is inferred or determined from reactivity ratios, which are measured through copolymerization experiments.…
View article: Regioisomeric Spirobifluorene CANAL Ladder Polymers and Their Gas Separation Performance
Regioisomeric Spirobifluorene CANAL Ladder Polymers and Their Gas Separation Performance Open
We synthesized and characterized two isomeric microporous hydrocarbon ladder polymers from catalytic arene norbornene annulation (CANAL) of regioisomeric bis-norbornene fused spirobifluorenes, where the ladder chains are connected either t…
View article: Ionizable Amino Lipids Distribution and Effects on DSPC/Cholesterol Membranes: Implications for Lipid Nanoparticle Structure
Ionizable Amino Lipids Distribution and Effects on DSPC/Cholesterol Membranes: Implications for Lipid Nanoparticle Structure Open
Lipid nanoparticles (LNPs) containing ionizable aminolipids are among the leading platforms for the successful delivery of nucleic-acid-based therapeutics, including messenger RNA (mRNA). The two recently FDA-approved COVID-19 vaccines dev…
View article: 3D bioprinting of dynamic hydrogel bioinks enabled by small molecule modulators
3D bioprinting of dynamic hydrogel bioinks enabled by small molecule modulators Open
Three-dimensional bioprinting has emerged as a promising tool for spatially patterning cells to fabricate models of human tissue. Here, we present an engineered bioink material designed to have viscoelastic mechanical behavior, similar to …
View article: Frontal Polymerization of Dihydrofuran Comonomer Facilitates Thermoset Deconstruction
Frontal Polymerization of Dihydrofuran Comonomer Facilitates Thermoset Deconstruction Open
Frontal ring-opening metathesis polymerization (FROMP) is a rapid, low-energy manufacturing reaction that is useful for curing thermosetting materials. FROMP of dicyclopentadiene (DCPD) results in poly(dicyclopentadiene) (p(DCPD)), a tough…
View article: Tools shaping drug discovery and development
Tools shaping drug discovery and development Open
Spectroscopic, scattering, and imaging methods play an important role in advancing the study of pharmaceutical and biopharmaceutical therapies. The tools more familiar to scientists within industry and beyond, such as nuclear magnetic reso…
View article: Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA
Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA Open
Lipid nanoparticles (LNPs) are capable of delivering messenger ribonucleic acid (mRNA) efficiently and systemically as a result of both particle composition and architecture. The particle architecture is determined by how the various compo…
View article: Predictably Engineering the Viscoelastic Behavior of Dynamic Hydrogels via Correlation with Molecular Parameters
Predictably Engineering the Viscoelastic Behavior of Dynamic Hydrogels via Correlation with Molecular Parameters Open
Rational design of dynamic hydrogels with desirable viscoelastic behaviors relies on an in‐depth understanding of the principles correlating molecular parameters and macroscopic properties. To quantitatively elucidate such principles, a se…
View article: Comparative experimental and computational study of synthetic and natural bottlebrush polyelectrolyte solutions
Comparative experimental and computational study of synthetic and natural bottlebrush polyelectrolyte solutions Open
We systematically investigate model synthetic and natural bottlebrush polyelectrolyte solutions through an array of experimental techniques (osmometry and neutron and dynamic light scattering) along with molecular dynamics simulations to c…
View article: Looping-in complexation and ion partitioning in nonstoichiometric polyelectrolyte mixtures
Looping-in complexation and ion partitioning in nonstoichiometric polyelectrolyte mixtures Open
The principles governing ion and macroion partitioning in nonstoichiometric coacervates are elucidated.
View article: Understanding the Mechanochemistry of Ladder-Type Cyclobutane Mechanophores by Single Molecule Force Spectroscopy
Understanding the Mechanochemistry of Ladder-Type Cyclobutane Mechanophores by Single Molecule Force Spectroscopy Open
We have recently reported a series of ladder-type cyclobutane mechanophores, polymers of which can transform from nonconjugated structures to conjugated structures and change many properties at once. These multicyclic mechanophores, namely…
View article: Design, Synthesis, and Biological Evaluation of Novel 6H-Benzo[c]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors
Design, Synthesis, and Biological Evaluation of Novel 6H-Benzo[c]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors Open
Urolithins (hydroxylated 6H-benzo[c]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series o…
View article: Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity Open
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published reports detailing how LNP biophysical properties can impact vaccine performance.…
View article: A Facile and Versatile Approach for the Synthesis of Degradable Polymers via Controlled Ring-Opening Metathesis Copolymerization
A Facile and Versatile Approach for the Synthesis of Degradable Polymers via Controlled Ring-Opening Metathesis Copolymerization Open
The authors have requested that this preprint be removed from Research Square.
View article: Engineered Matrices Enable the Culture of Human Patient‐Derived Intestinal Organoids
Engineered Matrices Enable the Culture of Human Patient‐Derived Intestinal Organoids Open
Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models. A tunable, fully defined, designer matrix, termed hyaluronan elastin‐like prot…
View article: Mechanochemical generation of acid-degradable poly(enol ether)s
Mechanochemical generation of acid-degradable poly(enol ether)s Open
A mechanically responsive polymer system that is hydrolytically stable without stress, but unmasks enol ether backbone linkages under force to allow facile hydrolytic degradation.