Youming Long
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View article: Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies Open
Piezo1, a trimeric mechanosensitive cation channel discovered in 2010 and recognized with the 2021 Nobel Prize for its seminal role in mechanotransduction, has emerged as a key transducer of mechanical forces into calcium ions (Ca 2+ ) sig…
View article: Impact of Treatment Delay and Prognostic Factors in Acute Myelitis of Neuromyelitis Optica Spectrum Disease
Impact of Treatment Delay and Prognostic Factors in Acute Myelitis of Neuromyelitis Optica Spectrum Disease Open
Objective This study aims to investigate the relationship between treatment delay and poor prognosis in acute myelitis of Neuromyelitis Optica Spectrum Disorder (NMOSD). Additionally, we seek to explore the related factors that contribute …
View article: A Comparative Study of 141 Glial Fibrillary Acidic Protein Immunoglobulin G Positive Cases
A Comparative Study of 141 Glial Fibrillary Acidic Protein Immunoglobulin G Positive Cases Open
Background Glial fibrillary acidic protein‐immunoglobulin G (GFAP‐IgG) positivity is associated with autoimmune GFAP astrocytopathy (GFAP‐A), but also with other autoimmune encephalitides and viral infections. We attempted to elucidate the…
View article: Efficacy and Safety of Ofatumumab Treatment for Anti‐<scp>NMDA</scp> Receptor Autoimmune Encephalitis (<scp>OFF</scp>‐<scp>AE</scp>): A Prospective, Multicenter Cohort Study
Efficacy and Safety of Ofatumumab Treatment for Anti‐<span>NMDA</span> Receptor Autoimmune Encephalitis (<span>OFF</span>‐<span>AE</span>): A Prospective, Multicenter Cohort Study Open
Objective Ofatumumab presents a potentially promising alternative to current second‐line immunotherapy for refractory anti‐N‐methyl‐D‐aspartate receptor autoimmune encephalitis (NMDAR‐AE). We aimed to evaluate the efficacy and safety of of…
View article: Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology
Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology Open
Objective The objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin‐4 or glial fibrillary acidic protein (GFAP) antibodies, while evaluating associated biomarkers and pathologies. M…
View article: IL-33 relieves nerve injury by mediating microglial polarization in neuromyelitis optica spectrum disorders via the IL-33/ST2 pathway
IL-33 relieves nerve injury by mediating microglial polarization in neuromyelitis optica spectrum disorders via the IL-33/ST2 pathway Open
Interleukin-33 (IL-33) is a member of the interleukin-1 cytokine family. Its function in regulating microglial M1/M2 polarization in neuromyelitis optica spectrum disorder (NMOSD) is still unelucidated. To evaluate the role of IL-33 in NMO…
View article: Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report
Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report Open
Objective This study aims to report three cases of autoimmune encephalitis followed by hemophagocytic lymphohistiocytosis. Methods Data of relevant patients treated between 2019 and 2022 were retrospectively collected from the Department o…
View article: Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus Open
Cognitive dysfunction is a feature in multiple sclerosis (MS), a chronic inflammatory demyelinating disorder. A notable aspect of MS brains is hippocampal demyelination, which is closely associated with cognitive decline. However, the mech…
View article: Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with <scp>HLA‐A</scp>*3303 and <scp>HLA‐DPB1</scp>*0501
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with <span>HLA‐A</span>*3303 and <span>HLA‐DPB1</span>*0501 Open
We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐…
View article: Case Report: Extraocular muscles paralysis associated with GAD65 antibody: a case series study
Case Report: Extraocular muscles paralysis associated with GAD65 antibody: a case series study Open
Objective To explore the clinical manifestations of glutamic acid decarboxylase 65 (GAD65) antibody-positive patients with extraocular symptoms and the possible mechanism. Method Assays for the presence of GAD65 antibodies were performed o…
View article: CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation
CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation Open
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and is known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such as neurodegeneration and autoimmune disorders…
View article: Early autoimmunity and outcome in virus encephalitis: a retrospective study based on tissue-based assay
Early autoimmunity and outcome in virus encephalitis: a retrospective study based on tissue-based assay Open
To explore the autoimmune response and outcome in the central nervous system (CNS) at the onset of viral infection and correlation between autoantibodies and viruses. Methods A retrospective observational study was conducted in 121 patient…
View article: Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases
Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases Open
Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an antibody-related astrocytic disease for which a specific GFAP antibody serves as a biological marker. Indeed, cerebral spinal fluid positive and/or seropositivity for…
View article: Differential Diagnosis of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy and Tuberculous Meningitis: A Multi-Center&nbsp;Observational&nbsp;Study Based on a Non-HIV Population
Differential Diagnosis of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy and Tuberculous Meningitis: A Multi-Center Observational Study Based on a Non-HIV Population Open
View article: DNER-IgG screening of 3290 cerebral spinal fluid samples: Two autoimmune cerebellar ataxia cases without tumors in long-term follow-up
DNER-IgG screening of 3290 cerebral spinal fluid samples: Two autoimmune cerebellar ataxia cases without tumors in long-term follow-up Open
This study aimed to retrospectively report the findings of delta/notch-like epidermal growth factor-related receptor (DNER)-immunoglobin G (IgG) in cerebral spinal fluid (CSF) in two cases with cerebellar ataxia. : CSF samples were collect…
View article: Effects of long-term magnesium L-threonate supplementation on neuroinflammation and blood–brain barrier integrity in mice with neuromyelitis optica spectrum disorder
Effects of long-term magnesium L-threonate supplementation on neuroinflammation and blood–brain barrier integrity in mice with neuromyelitis optica spectrum disorder Open
Objective We aimed to elucidate the effects of and the potential mechanism underlying long-term magnesium supplementation on blood–brain barrier integrity in mice with neuromyelitis optica spectrum disorder (NMOSD), a severe and disabling …
View article: Serological biomarkers in autoimmune GFAP astrocytopathy
Serological biomarkers in autoimmune GFAP astrocytopathy Open
Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a newly defined meningoencephalomyelitis. The pathogenesis of GFAP-A is not well understood. The present study measured the expression levels of 200 serological cytokine…
View article: Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: To Identify Its Diagnosis, Management and Prognosis (GFAP-AID) Registry: Study Protocol for an Ambispective, Multicenter Registry in China
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: To Identify Its Diagnosis, Management and Prognosis (GFAP-AID) Registry: Study Protocol for an Ambispective, Multicenter Registry in China Open
ChiCTR2000041291.
View article: Development of a Nomogram for Predicting Asymptomatic CoronaryArtery Disease in Patients with Ischemic Stroke
Development of a Nomogram for Predicting Asymptomatic CoronaryArtery Disease in Patients with Ischemic Stroke Open
Background: Coronary artery stenosis (CAS) ≥50% often coexists in patients with ischemic stroke, which leads to a significant increase in the occurrence of major vascular events after stroke. This study aimed to develop a nomogram for diag…
View article: Therapeutic Response and Possible Biomarkers in Acute Attacks of Neuromyelitis Optica Spectrum Disorders: A Prospective Observational Study
Therapeutic Response and Possible Biomarkers in Acute Attacks of Neuromyelitis Optica Spectrum Disorders: A Prospective Observational Study Open
Objective To explore the outcomes of NMOSD attacks and investigate serum biomarkers for prognosis and severity. Method Patients with NMOSD attacks were prospectively and observationally enrolled from January 2019 to December 2020 at four h…
View article: Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases
Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases Open
Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an antibody-related astrocytic disease for which a specific GFAP antibody serves as a biological marker. Indeed, cerebral spinal fluid positive and/or seropositivity for…
View article: Status of Immunotherapy Acceptance in Chinese Patients With Multiple Sclerosis: Analysis of Multiple Sclerosis Patient Survival Report 2018
Status of Immunotherapy Acceptance in Chinese Patients With Multiple Sclerosis: Analysis of Multiple Sclerosis Patient Survival Report 2018 Open
Objective: The prevalence of multiple sclerosis (MS) in China is low, although it has been increasing recently. Owing to the paucity of data on immunotherapy acceptance in the Chinese population, we conducted this study to analyze factors …
View article: Serum Molecular Biomarkers in Neuromyelitis Optical and Multiple Sclerosis
Serum Molecular Biomarkers in Neuromyelitis Optical and Multiple Sclerosis Open
ObjectiveThe aims of this study were to determine whether the expression levels of serological cytokines could distinguish 1) neuromyelitis optical spectrum disorders (NMOSD) from healthy controls (HCs); and 2) NMOSD patients with and with…
View article: Autoimmune glial fibrillary acidic protein astrocytopathy with lesions distributed predominantly in the entire spinal cord
Autoimmune glial fibrillary acidic protein astrocytopathy with lesions distributed predominantly in the entire spinal cord Open
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy has been considered a novel central nervous system autoimmune disease characterized by relapse and responsiveness to corticosteroid with a specific GFAP-Immunoglobulin G (IgG…
View article: Brain histopathological study and prognosis in <scp>MOG</scp> antibody‐associated demyelinating pseudotumor
Brain histopathological study and prognosis in <span>MOG</span> antibody‐associated demyelinating pseudotumor Open
Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody‐associated demyelinating pseudotumor. The clinical, MRI , and histological featur…
View article: Mesenchymal stromal cells attenuate multiple sclerosis <i>via</i> IDO-dependent increasing the suppressive proportion of CD5+ IL-10+ B cells.
Mesenchymal stromal cells attenuate multiple sclerosis <i>via</i> IDO-dependent increasing the suppressive proportion of CD5+ IL-10+ B cells. Open
Multiple sclerosis (MS), one of the autoimmune and inflammatory diseases, is a major cause of neurological disability worldwide. The existing clinical treatments are not curable, and better treatments are urgently needed. Mesenchymal strom…
View article: Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature Open
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an autoimmune disease of the nervous system first defined in 2016. GFAP autoantibody, especially IgG that binds to GFAPα, has been reported in the cerebrospinal fluid (CSF…
View article: Low-Dose Mycophenolate Mofetil for Treatment of Neuromyelitis Optica Spectrum Disorders: A Prospective Multicenter Study in South China
Low-Dose Mycophenolate Mofetil for Treatment of Neuromyelitis Optica Spectrum Disorders: A Prospective Multicenter Study in South China Open
www.ClinicalTrials.gov, identifier : NCT02809079.
View article: Overlapping Autoimmune Syndromes in Patients With Glial Fibrillary Acidic Protein Antibodies
Overlapping Autoimmune Syndromes in Patients With Glial Fibrillary Acidic Protein Antibodies Open
Overlapping antibodies are common in GFAP astrocytopathy.
View article: Different Phenotypes at Onset in Neuromyelitis Optica Spectrum Disorder Patients with Aquaporin-4 Autoimmunity
Different Phenotypes at Onset in Neuromyelitis Optica Spectrum Disorder Patients with Aquaporin-4 Autoimmunity Open
NMOSD patients with different initial manifestations present with significant differences in clinical features during follow-up. Patients with long-term AQP4 autoimmunity in the brain in the absence of ON or TM are not common.