Young‐Ah Youn
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View article: Cumulative Hydrocortisone Exposure and Early Brain Volumetrics in Very Low Birth Weight Infants: Associations with Neurodevelopmental Outcomes
Cumulative Hydrocortisone Exposure and Early Brain Volumetrics in Very Low Birth Weight Infants: Associations with Neurodevelopmental Outcomes Open
Background/Objectives: Systemic hydrocortisone (HCS) in very low birth weight (VLBW) infants is commonly used to treat early hypotension or prevent bronchopulmonary dysplasia. This study evaluated the associations between postnatal HCS exp…
View article: Early-Life Development of the Intestinal Microbiome in Preterm and Term Infants Hospitalized in the Neonatal Intensive Care Unit
Early-Life Development of the Intestinal Microbiome in Preterm and Term Infants Hospitalized in the Neonatal Intensive Care Unit Open
This prospective cohort study investigated the longitudinal compositional changes of the gut microbiome across different gestational age groups, from birth to six months’ corrected age for prematurity. Fecal samples (n = 709) from 349 neon…
View article: Two fatal case reports of cardiac tamponade caused by pericardial effusion due to misplaced peripherally inserted central catheters in extremely low birth weight infants
Two fatal case reports of cardiac tamponade caused by pericardial effusion due to misplaced peripherally inserted central catheters in extremely low birth weight infants Open
Rationale: Vascular access is a critical component of care in the neonatal intensive care unit, especially for nutritional support and medication administration. While umbilical vein catheters are commonly used during the first few days of…
View article: Addressing the gap in preterm resuscitation practices in high-income and low-middle income countries: a multicenter survey of the Asian neonatal network collaboration
Addressing the gap in preterm resuscitation practices in high-income and low-middle income countries: a multicenter survey of the Asian neonatal network collaboration Open
Background Optimum neonatal resuscitation practices are vital for improving neonatal survival and neurodevelopment outcomes, particularly in extremely preterm infants. However, such practices may vary between high-income countries (HICs) a…
View article: The impact of clinical seizures and adverse brain MRI patterns in neonates with hypoxic-ischemic encephalopathy and abnormal neurodevelopment
The impact of clinical seizures and adverse brain MRI patterns in neonates with hypoxic-ischemic encephalopathy and abnormal neurodevelopment Open
Clinical seizures in infants with HIE were independently associated with abnormal neurodevelopment. However, cord blood pH and abnormal brain MRI findings were consistently linked to long-term neurodevelopmental outcomes.
View article: Dysbiosis of the initial stool microbiota increases the risk of developing necrotizing enterocolitis or feeding intolerance in newborns
Dysbiosis of the initial stool microbiota increases the risk of developing necrotizing enterocolitis or feeding intolerance in newborns Open
View article: Structural development and brain asymmetry in the fronto-limbic regions in preschool-aged children
Structural development and brain asymmetry in the fronto-limbic regions in preschool-aged children Open
Early-life experiences play a crucial role in the development of the fronto-limbic regions, influencing both macro- and microstructural changes in the brain. These alterations profoundly impact cognitive, social-emotional functions. Recent…
View article: Evaluation of a Diazo‐Based Point‐Of‐Care Bilirubin Assay <scp>careSTART S1</scp> Total Bilirubin Strip
Evaluation of a Diazo‐Based Point‐Of‐Care Bilirubin Assay <span>careSTART S1</span> Total Bilirubin Strip Open
Background Neonatal jaundice (NNJ) affects a significant proportion of newborns globally, with an increased burden in low‐resource settings. Effective health risk management of NNJ is hindered, particularly in resource‐constrained environm…
View article: Asian Neonatal Network Collaboration (AsianNeo): a study protocol for international collaborative comparisons of health services and outcomes to improve quality of care for sick newborn infants in Asia – survey, cohort and quality improvement studies
Asian Neonatal Network Collaboration (AsianNeo): a study protocol for international collaborative comparisons of health services and outcomes to improve quality of care for sick newborn infants in Asia – survey, cohort and quality improvement studies Open
Introduction Reducing neonatal deaths in premature infants in low- and middle-income countries is key to reducing global neonatal mortality. International neonatal networks, along with patient registries of premature infants, have contribu…
View article: Gut Dysbiosis in the First-Passed Meconium Microbiomes of Korean Preterm Infants Compared to Full-Term Neonates
Gut Dysbiosis in the First-Passed Meconium Microbiomes of Korean Preterm Infants Compared to Full-Term Neonates Open
Since gestational age (GA) is an important factor influencing the presence of specific microbiomes, we aimed to characterize the core microbiomes of preterm infants compared to full-term (FT) infants. This study investigated the difference…
View article: Enhanced Survival of 22–25 Week Preterm Infants After Proactive Care Implementation: A Comparative Analysis of Two Time Periods
Enhanced Survival of 22–25 Week Preterm Infants After Proactive Care Implementation: A Comparative Analysis of Two Time Periods Open
Objectives To investigate the impact of proactive perinatal care on periviable preterm infants before and after its implementation. Methods This retrospective cohort study was conducted over a period of 10 y, from 2013 to 2019, referred to…
View article: Risk factors for PDA ligation and neurodevelopmental outcomes at corrected 18–24 months in very low birth weight infants
Risk factors for PDA ligation and neurodevelopmental outcomes at corrected 18–24 months in very low birth weight infants Open
Background Patent ductus arteriosus (PDA) is commonly encountered morbidity which often occurs as up to 60% of extremely preterm infants born at < 29 weeks gestational age (GA). Purpose This study aims to assess the clinical risk factors a…
View article: Comparative analysis of the quantitative point-of-care CareSTART™ total bilirubin with central laboratory total bilirubin assays in neonatal blood samples
Comparative analysis of the quantitative point-of-care CareSTART™ total bilirubin with central laboratory total bilirubin assays in neonatal blood samples Open
This study aimed to assess and compare the accuracy of point-of-care CareSTART™ S1 Total Bilirubin test with a central laboratory total bilirubin assay using neonatal samples. This study was conducted using 152 paired measurements obtained…
View article: The effect of minimizing central line days for very low birth weight infants through quality improvement
The effect of minimizing central line days for very low birth weight infants through quality improvement Open
Blood culture proven sepsis is associated with increased mortality and morbidity. Given the extended hospitalization of very preterm infants, catheter-related blood stream infections (CRBSIs) play a substantial role in sepsis. The reported…
View article: Volumetric changes in brain MRI of infants with hypoxic-ischemic encephalopathy and abnormal neurodevelopment who underwent therapeutic hypothermia
Volumetric changes in brain MRI of infants with hypoxic-ischemic encephalopathy and abnormal neurodevelopment who underwent therapeutic hypothermia Open
In addition to assessing the location of brain injuries in MRI scans, the reduction in brain stem volume coupled with an increase in ventricular volume in HIE infants may serve as a biomarker indicating severe HIE and adverse long-term ND …
View article: Variations in medical practice of retinopathy of prematurity among 8 Asian countries from an international survey
Variations in medical practice of retinopathy of prematurity among 8 Asian countries from an international survey Open
Advances in perinatal care have led to the increased survival of preterm infants with subsequent neonatal morbidities, such as retinopathy of prematurity (ROP). This study aims to compare the differences of neonatal healthcare systems, res…
View article: Volumetric changes in brain MRI of infants with abnormal development who had Hypoxic-ischemic Encephalopathy and underwent therapeutic hypothermia
Volumetric changes in brain MRI of infants with abnormal development who had Hypoxic-ischemic Encephalopathy and underwent therapeutic hypothermia Open
Background Hypoxic-ischemic encephalopathy (HIE) is a severe neonatal complication that can result in 40–60% of long-term morbidity. MRI is a noninvasive method which is usually performed before discharge to visually assess acquired cerebr…
View article: Using adenosine triphosphate bioluminescence level monitoring to identify bacterial reservoirs during two consecutive Enterococcus faecium and Staphylococcus capitis nosocomial infection outbreaks at a neonatal intensive care unit
Using adenosine triphosphate bioluminescence level monitoring to identify bacterial reservoirs during two consecutive Enterococcus faecium and Staphylococcus capitis nosocomial infection outbreaks at a neonatal intensive care unit Open
Introduction This study aimed to assess the role of adenosine triphosphate (ATP) bioluminescence level monitoring for identifying reservoirs of the outbreak pathogen during two consecutive outbreaks caused by Enterococcus faecium and Staph…
View article: Volumetric Changes in Brain MRI of Infants with Abnormal Development Who Had Hypoxic-Ischemic Encephalopathy and Underwent Therapeutic Hypothermia
Volumetric Changes in Brain MRI of Infants with Abnormal Development Who Had Hypoxic-Ischemic Encephalopathy and Underwent Therapeutic Hypothermia Open
View article: Compositional Differences of Meconium Microbiomes of Preterm and Term Infants, and Infants That Developed Necrotizing Enterocolitis or Feeding Intolerance
Compositional Differences of Meconium Microbiomes of Preterm and Term Infants, and Infants That Developed Necrotizing Enterocolitis or Feeding Intolerance Open
The primary aim of this study was to investigate the compositional differences of the first passed meconium microbiome in preterm and term infants, and the secondary aim was to compare the meconium microbiomes of preterm and term infants t…
View article: The prognosis of refractory hypotension and severe intraventricular hemorrhage in very low birth weight infants
The prognosis of refractory hypotension and severe intraventricular hemorrhage in very low birth weight infants Open
Background: The increased survival rate among very low birth weight infants has resulted in a higher risk for developing neuro-complications such as intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), and adverse neurode…
View article: Predictive Value of Heat-Shock Protein Gene Expression on Severe Neonatal Hypoxic-Ischemic Encephalopathy
Predictive Value of Heat-Shock Protein Gene Expression on Severe Neonatal Hypoxic-Ischemic Encephalopathy Open
This study aims to evaluate significant gene expression in severe hypoxic ischemic encephalopathy (HIE) in newborns, which can be used as a predictable measure for high-risk HIE infants. The study prospectively recruited 77 inborn near-ter…
View article: The Prognosis of Refractory Hypotension and Severe Intraventricular Hemorrhage in Very Low Birth Weight Infants
The Prognosis of Refractory Hypotension and Severe Intraventricular Hemorrhage in Very Low Birth Weight Infants Open
Background: The increased survival rate among very low birth weight infants has resulted in a higher risk for developing neurocomplications such as intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and adverse neurodeve…
View article: Preventive Intervention Program on the Outcomes of Very Preterm Infants and Caregivers: A Multicenter Randomized Controlled Trial
Preventive Intervention Program on the Outcomes of Very Preterm Infants and Caregivers: A Multicenter Randomized Controlled Trial Open
Increased survival in the very preterm population results in a higher risk of developing neurodevelopmental and behavioral disabilities among survivors. We examined the outcomes of very preterm infants and parents after a preventive interv…
View article: Clinical seizures and unfavorable brain MRI patterns in neonates with hypoxic ischemic encephalopathy
Clinical seizures and unfavorable brain MRI patterns in neonates with hypoxic ischemic encephalopathy Open
The aim was to examine whether clinical seizures and amplitude-integrated electroencephalogram (aEEG) patterns in infants with hypoxic ischemic encephalopathy (HIE) can predict the extent of brain injury on magnetic resonance images (MRI) …
View article: A newborn with developmental delay diagnosed with 4q35 deletion and 10p duplication
A newborn with developmental delay diagnosed with 4q35 deletion and 10p duplication Open
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View article: Predictive Values of Location and Volumetric MRI Injury Patterns for Neurodevelopmental Outcomes in Hypoxic-Ischemic Encephalopathy Neonates
Predictive Values of Location and Volumetric MRI Injury Patterns for Neurodevelopmental Outcomes in Hypoxic-Ischemic Encephalopathy Neonates Open
Hypoxic-ischemic encephalopathy (HIE) is a severe neonatal complication with up to 40–60% long-term morbidity. This study evaluates the distribution and burden of MRI changes as a prognostic indicator of neurodevelopmental (ND) outcomes at…
View article: The prognosis of brain magnetic resonance imaging injury pattern for outcomes of hypothermia-treated infants
The prognosis of brain magnetic resonance imaging injury pattern for outcomes of hypothermia-treated infants Open
Magnetic resonance imaging (MRI) can be a tool that allows the observation of structural injury patterns after cooling. The aim of this study was to determine the early pattern of brain injury in the MRIs of infants with hypoxic ischemic e…
View article: Short- and long-term outcomes of very low birth weight infants in Korea: Korean Neonatal Network update in 2019
Short- and long-term outcomes of very low birth weight infants in Korea: Korean Neonatal Network update in 2019 Open
Korea currently has the world’s lowest birth rate but a rapidly inreasing number of preterm infants. The Korean Neonatal Network (KNN), launched by the Korean Society of Neonatology under the support of Korea Centers for Disease Control, h…
View article: Early Hydrocortisone Use and Severe Retinopathy of Prematurity in Very Low Birth Weight Infants
Early Hydrocortisone Use and Severe Retinopathy of Prematurity in Very Low Birth Weight Infants Open