Young‐Eun Kim
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View article: Differential Peripheral NLRP3 Inflammasome Expression in Parkinson's Disease and Multiple System Atrophy
Differential Peripheral NLRP3 Inflammasome Expression in Parkinson's Disease and Multiple System Atrophy Open
Our findings challenge the prevailing hypothesis that NLRP3 inflammasome activation directly contributes to PD pathogenesis. Instead, the observed increase in ASC and caspase-1 expression suggests the potential involvement of alternative i…
View article: Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders
Extracellular vesicles from mesenchymal stromal cells: an emerging therapy for intractable neonatal disorders Open
Neonatal disorders affecting different organs are highly multifactorial and involve a complex interplay among prematurity, inflammation, oxidative stress, tissue injury, immune dysregulation, and impaired regeneration. Conditions such as h…
View article: The relationship between behavioral activation and burnout in a community setting: the mediating role of acceptance-based action, automatic negative thought, and self-efficacy
The relationship between behavioral activation and burnout in a community setting: the mediating role of acceptance-based action, automatic negative thought, and self-efficacy Open
Introduction Burnout, a work-related syndrome, considerably overlaps with depression. Despite its negative impact on modern society, the underlying mechanisms and effective interventions remain unclear. This study explores the effects of b…
View article: The epidemiology and burden of ten mental disorders in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021
The epidemiology and burden of ten mental disorders in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021 Open
Gates Foundation.
View article: The epidemiology and burden of cardiovascular diseases in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021
The epidemiology and burden of cardiovascular diseases in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021 Open
The Gates Foundation.
View article: The epidemiology and burden of injury in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021
The epidemiology and burden of injury in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021 Open
View article: Effects of Pancreatitis and Type 2 Diabetes Mellitus on the Development of Pancreatic Cancer: A Nationwide Nested Case-Control Study (Diabetes Metab J 2025;49:252-63)
Effects of Pancreatitis and Type 2 Diabetes Mellitus on the Development of Pancreatic Cancer: A Nationwide Nested Case-Control Study (Diabetes Metab J 2025;49:252-63) Open
View article: <i>Hovenia dulcis</i> Honey Suppresses Androgen‐Induced Epithelial–Mesenchymal Transition in Benign Prostatic Hyperplasia
<i>Hovenia dulcis</i> Honey Suppresses Androgen‐Induced Epithelial–Mesenchymal Transition in Benign Prostatic Hyperplasia Open
Benign prostate hyperplasia (BPH) is characterized by abnormal prostate epithelial and stromal cell growth, which leads to bladder outlet obstruction (BOO) and lower urinary tract symptoms (LUTS). BPH pathogenesis involves key signaling pa…
View article: Functional maturation of preterm intestinal epithelium through CFTR activation
Functional maturation of preterm intestinal epithelium through CFTR activation Open
View article: Prevalence and Clinical Impact of Alpha-Synuclein Pathology in Idiopathic Normal Pressure Hydrocephalus: Insights from Rt-Quic Assay
Prevalence and Clinical Impact of Alpha-Synuclein Pathology in Idiopathic Normal Pressure Hydrocephalus: Insights from Rt-Quic Assay Open
View article: How Do Flood Risk-Socioeconomic Interactions Influence Household Income Dynamics in Shrinking Cities of the Rust Belt?
How Do Flood Risk-Socioeconomic Interactions Influence Household Income Dynamics in Shrinking Cities of the Rust Belt? Open
View article: Corrigendum to The risk of pregnancy-related adverse outcomes after COVID-19 vaccination: propensity score-matched analysis with influenza vaccination
Corrigendum to The risk of pregnancy-related adverse outcomes after COVID-19 vaccination: propensity score-matched analysis with influenza vaccination Open
View article: 8297 Risk Of Pancreatic Cancer In Patients With Diabetes Mellitus And Pancreatitis: A Nationwide Nested Case-Control Study
8297 Risk Of Pancreatic Cancer In Patients With Diabetes Mellitus And Pancreatitis: A Nationwide Nested Case-Control Study Open
Disclosure: Y. Kim: None. H. Kim: None. M. Yu: None. C. Nam: None. E. Kang: None. Background: Despite diabetes mellitus and pancreatitis being known risk factors for pancreatic cancer, but because of their low incidence, patients with thes…
View article: A Study on the Relationship between Allergic Diseases and Gastrointestinal Discomfort Symptoms: Using Propensity Score Matching
A Study on the Relationship between Allergic Diseases and Gastrointestinal Discomfort Symptoms: Using Propensity Score Matching Open
Objectives: This study aimed to investigate the relationship between allergic diseases and digestive discomfort symptoms using a dataset for the traditional Korean medicine examination.Methods: The study included 389 subjects in the allerg…
View article: Incidence of Panic Disorder Diagnoses After Celebrity Disclosures of Panic Disorder in South Korea
Incidence of Panic Disorder Diagnoses After Celebrity Disclosures of Panic Disorder in South Korea Open
Importance The persistent stigma associated with mental health conditions is a major challenge worldwide. Celebrities may improve this by openly discussing their own mental health issues, potentially influencing public attitudes and encour…
View article: Statistical Analysis by Semiparametric Additive Regression and LSTM-FCN Based Hierarchical Classification for Computer Vision Quantification of Parkinsonian Bradykinesia
Statistical Analysis by Semiparametric Additive Regression and LSTM-FCN Based Hierarchical Classification for Computer Vision Quantification of Parkinsonian Bradykinesia Open
Bradykinesia, characterized by involuntary slowing or decrement of movement, is a fundamental symptom of Parkinson's Disease (PD) and is vital for its clinical diagnosis. Despite various methodologies explored to quantify bradykinesia, com…
View article: Pet and Abandoned Pet Content UX Design for Metaverse -Based on Virtual Identity, Interaction, Synchronicity, and Experience Value-
Pet and Abandoned Pet Content UX Design for Metaverse -Based on Virtual Identity, Interaction, Synchronicity, and Experience Value- Open
본 연구는 메타버스 UX 디자인 프레임을 토대로 반려동물·유기 동물 메타버스 콘텐츠 설계를 목표로 한다. 플랫폼 특성에 적합한 콘텐츠를 설계하기 위해 메타버스 속성을 고찰하고, 그중 가상 자아, 상호작용, 동시성, 경험가치를 UX 디자인 프레임워크로 설정하여 속성별 적용 대상과 실현 방식에 대해 구체적으로 제시하였다. 이를 바탕으로 제안된 콘텐츠로는 가상의 반려동물을 양육할 수 있는 자신만의 집, 친숙도에 따라 다른 가상동물…
View article: Mesenchymal Stromal Cells Primed by Toll-like Receptors 3 and 4 Enhanced Anti-Inflammatory Effects against LPS-Induced Macrophages via Extracellular Vesicles
Mesenchymal Stromal Cells Primed by Toll-like Receptors 3 and 4 Enhanced Anti-Inflammatory Effects against LPS-Induced Macrophages via Extracellular Vesicles Open
Although it has been suggested that toll-like receptor (TLR) 3 and TLR4 activation alters mesenchymal stromal cells (MSCs)’ immunoregulatory function as anti- or pro-inflammatory phenotypes, we have previously confirmed that TLR4-primed hU…
View article: Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021 Open
View article: Herpes Zoster Reactivation After mRNA and Adenovirus-Vectored Coronavirus Disease 2019 Vaccination: Analysis of National Health Insurance Database
Herpes Zoster Reactivation After mRNA and Adenovirus-Vectored Coronavirus Disease 2019 Vaccination: Analysis of National Health Insurance Database Open
Background Our study aimed to determine the risk of herpes zoster reactivation and coronavirus disease 2019 (COVID-19) vaccination (mRNA vaccine [BNT162b2] and adenovirus-vectored vaccine [ChAdOx1 nCoV-19]). Methods This retrospective stud…
View article: Updating Korean Disability Weights for Causes of Disease: Adopting an Add-on Study Method
Updating Korean Disability Weights for Causes of Disease: Adopting an Add-on Study Method Open
Objectives: Disability weights require regular updates, as they are influenced by both diseases and societal perceptions. Consequently, it is necessary to develop an up-to-date list of the causes of diseases and establish a survey panel fo…
View article: SOCS3 Protein Mediates the Therapeutic Efficacy of Mesenchymal Stem Cells against Acute Lung Injury
SOCS3 Protein Mediates the Therapeutic Efficacy of Mesenchymal Stem Cells against Acute Lung Injury Open
Mesenchymal stem cells (MSCs) have been studied as novel therapeutic agents because of their immunomodulatory properties in inflammatory diseases. The suppressor of cytokine signaling (SOCS) proteins are key regulators of the immune respon…
View article: Supplementary Methods from Monoclonal Antibody Targeting of the Cell Surface Molecule TM4SF5 Inhibits the Growth of Hepatocellular Carcinoma
Supplementary Methods from Monoclonal Antibody Targeting of the Cell Surface Molecule TM4SF5 Inhibits the Growth of Hepatocellular Carcinoma Open
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View article: Case report: Cerebrotendinous xanthomatosis with a novel mutation in the CYP27A1 gene mimicking behavioral variant frontotemporal dementia
Case report: Cerebrotendinous xanthomatosis with a novel mutation in the CYP27A1 gene mimicking behavioral variant frontotemporal dementia Open
Background Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease caused by a mutation in the CYP27A1 gene. Due to the disruption of bile acid synthesis leading to cholesterol and cholestanol accumulation,…
View article: Mesenchymal stem cells reduced the extracellular mitochondrial DNA-mediated TLR9 activation in neonatal hyperoxia-induced lung injury
Mesenchymal stem cells reduced the extracellular mitochondrial DNA-mediated TLR9 activation in neonatal hyperoxia-induced lung injury Open
Mitochondrial DNA (mtDNA) released from the dead or injured cells can activate inflammation and mesenchymal stem cell (MSC) transplantation can reduce inflammatory injury. However, it has not been tested whether the release of mtDNA can be…
View article: COVID-19 Vaccination Status Among Korean Pediatric Population With Comorbidities
COVID-19 Vaccination Status Among Korean Pediatric Population With Comorbidities Open
The pediatric population with comorbidities is a high-risk group for severe coronavirus disease 2019 (COVID-19). As of January 2023, the COVID-19 vaccination rate for at least two doses among Korean children 5-11 years is low at 1.1%. We s…
View article: Severe Coronavirus Disease 2019 in Paediatric Solid Organ Transplant Recipients: Big Data Convergence Study in Korea ((K-COV-N Cohort)
Severe Coronavirus Disease 2019 in Paediatric Solid Organ Transplant Recipients: Big Data Convergence Study in Korea ((K-COV-N Cohort) Open
View article: Erratum: Correction of Authors in the Article “Relevance Index Regional Variation by Each Disease and Its Essential Medical Field: A Retrospective Data Analysis From 2016–2020 in Korea”
Erratum: Correction of Authors in the Article “Relevance Index Regional Variation by Each Disease and Its Essential Medical Field: A Retrospective Data Analysis From 2016–2020 in Korea” Open
This corrects the article on p. e130 in vol. 38, PMID: 37096313.
View article: Impact of Celebrity Disclosures on the Incidence and Prevalence of Panic Disorder in South Korea: An Interrupted Time-Series Analysis
Impact of Celebrity Disclosures on the Incidence and Prevalence of Panic Disorder in South Korea: An Interrupted Time-Series Analysis Open
View article: The effects of an emergency department length-of-stay management system on severely ill patients’ treatment outcomes
The effects of an emergency department length-of-stay management system on severely ill patients’ treatment outcomes Open