Seong‐Cheol Park
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View article: Self-boosting targeted anticancer therapy <i>via</i> cancer cell self-reprogramming with GGT-targeting oxidative stress nanoamplifiers
Self-boosting targeted anticancer therapy <i>via</i> cancer cell self-reprogramming with GGT-targeting oxidative stress nanoamplifiers Open
View article: Alteration of the Antifungal Action Mechanism Due to Structural Changes in the Antimicrobial Peptide, HnMc
Alteration of the Antifungal Action Mechanism Due to Structural Changes in the Antimicrobial Peptide, HnMc Open
The rapid induction of drug resistance is considered a fatal drawback of conventional antibiotics and requires the continuous development of new antibiotics. Accordingly, antibacterial peptides (AMPs) have attracted interest as next-genera…
View article: Differential response of SNU-1826 colon cells on the autophagy, ER stress, and inflammation during the regulation of microplastic internalization
Differential response of SNU-1826 colon cells on the autophagy, ER stress, and inflammation during the regulation of microplastic internalization Open
The internalization mechanism of microplastics (MPs) into human cells has attracted considerable attention because these mechanisms are closely related to the physical and chemical properties of MPs. This study examined the response of hum…
View article: Targeted delivery of amphotericin B-loaded PLGA micelles displaying lipopeptides to drug-resistant Candida-infected skin
Targeted delivery of amphotericin B-loaded PLGA micelles displaying lipopeptides to drug-resistant Candida-infected skin Open
Amphotericin B (AmB) is an antifungal agent administered for the management of serious systemic fungal infections. However, its clinical application is limited because of its water insolubility and side effects. Herein, to apply the minimu…
View article: Advancing Breast Cancer Therapeutics: Targeted Gene Delivery Systems Unveiling the Potential of Estrogen Receptor-Targeting Ligands
Advancing Breast Cancer Therapeutics: Targeted Gene Delivery Systems Unveiling the Potential of Estrogen Receptor-Targeting Ligands Open
Although curcumin has been well known as a phytochemical drug that inhibits tumor promotion by modulating multiple molecular targets, its potential was not reported as a targeting ligand in the field of drug delivery system. Here, we aimed…
View article: Antifungal Action of Arabidopsis thaliana TCP21 via Induction of Oxidative Stress and Apoptosis
Antifungal Action of Arabidopsis thaliana TCP21 via Induction of Oxidative Stress and Apoptosis Open
The realm of antimicrobial proteins in plants is extensive but remains relatively uncharted. Understanding the mechanisms underlying the action of plant antifungal proteins (AFPs) holds promise for antifungal strategies. This study aimed t…
View article: Potent Antifungal Functions of a Living Modified Organism Protein, CP4-EPSPS, against Pathogenic Fungal Cells
Potent Antifungal Functions of a Living Modified Organism Protein, CP4-EPSPS, against Pathogenic Fungal Cells Open
Various proteins introduced into living modified organism (LMO) crops function in plant defense mechanisms against target insect pests or herbicides. This study analyzed the antifungal effects of an introduced LMO protein, 5-enolpyruvylshi…
View article: Author Correction: High-harmonic generation from a flat liquid-sheet plasma mirror
Author Correction: High-harmonic generation from a flat liquid-sheet plasma mirror Open
View article: High-harmonic generation from a flat liquid-sheet plasma mirror
High-harmonic generation from a flat liquid-sheet plasma mirror Open
High-harmonic radiation can be generated when an ultra-intense laser beam is reflected from an over-dense plasma, known as a plasma mirror. It is considered a promising technique for generating intense attosecond pulses in the extreme ultr…
View article: Anti-Biofilm Effects of Rationally Designed Peptides against Planktonic Cells and Pre-Formed Biofilm of Pseudomonas aeruginosa
Anti-Biofilm Effects of Rationally Designed Peptides against Planktonic Cells and Pre-Formed Biofilm of Pseudomonas aeruginosa Open
Biofilms are resistant to antibiotics and are a major source of persistent and recurring infections by clinically important pathogens. Drugs used for biofilm-associated infections are limited because biofilm-embedded or biofilm-matrix bact…
View article: Antifungal and Anti-Inflammatory Activities of PS1-2 Peptide against Fluconazole-Resistant Candida albicans
Antifungal and Anti-Inflammatory Activities of PS1-2 Peptide against Fluconazole-Resistant Candida albicans Open
Clinically, fungal pneumonia rarely occurs in adults, and invasive fungal infections can cause substantial morbidity, and mortality due to sepsis and septic shock. In the present study, we have designed peptides that exhibit potent antifun…
View article: Potent Anti-Inflammatory Effects of a Helix-to-Helix Peptide against Pseudomonas aeruginosa Endotoxin-Mediated Sepsis
Potent Anti-Inflammatory Effects of a Helix-to-Helix Peptide against Pseudomonas aeruginosa Endotoxin-Mediated Sepsis Open
Although considerable scientific research data is available for sepsis and cytokine storm syndrome, there is a need to develop new treatments or drugs for sepsis management. Antimicrobial peptides (AMPs) possess anti-bacterial and anti-inf…
View article: Design of Antimicrobial Peptides with Cell-Selective Activity and Membrane-Acting Mechanism against Drug-Resistant Bacteria
Design of Antimicrobial Peptides with Cell-Selective Activity and Membrane-Acting Mechanism against Drug-Resistant Bacteria Open
Antimicrobial peptides (AMPs) can combat drug-resistant bacteria with their unique membrane-disruptive mechanisms. This study aimed to investigate the antibacterial effects of several membrane-acting peptides with amphipathic structures an…
View article: Functional Characterization of an Arabidopsis Profilin Protein as a Molecular Chaperone under Heat Shock Stress
Functional Characterization of an Arabidopsis Profilin Protein as a Molecular Chaperone under Heat Shock Stress Open
Profilins (PFNs) are actin monomer-binding proteins that function as antimicrobial agents in plant phloem sap. Although the roles of Arabidopsis thaliana profilin protein isoforms (AtPFNs) in regulating actin polymerization have already be…
View article: Candidacidal and Antibiofilm Activity of PS1-3 Peptide against Drug-Resistant Candida albicans on Contact Lenses
Candidacidal and Antibiofilm Activity of PS1-3 Peptide against Drug-Resistant Candida albicans on Contact Lenses Open
The recent emergence of antibiotic-resistant fungi has accelerated research on novel antifungal agents. In particular, Candida albicans infections are related to biofilm formation on medical devices, such as catheters, stents, and contact …
View article: Deep-Learning-Based Cerebral Artery Semantic Segmentation in Neurosurgical Operating Microscope Vision Using Indocyanine Green Fluorescence Videoangiography
Deep-Learning-Based Cerebral Artery Semantic Segmentation in Neurosurgical Operating Microscope Vision Using Indocyanine Green Fluorescence Videoangiography Open
There have been few anatomical structure segmentation studies using deep learning. Numbers of training and ground truth images applied were small and the accuracies of which were low or inconsistent. For a surgical video anatomy analysis, …
View article: Antifungal Mechanism of Vip3Aa, a Vegetative Insecticidal Protein, against Pathogenic Fungal Strains
Antifungal Mechanism of Vip3Aa, a Vegetative Insecticidal Protein, against Pathogenic Fungal Strains Open
Discovering new antifungal agents is difficult, since, unlike bacteria, mammalian and fungal cells are both eukaryotes. An efficient strategy is to consider new antimicrobial proteins that have variety of action mechanisms. In this study, …
View article: Erratum to: Antibacterial Effects of Amino Acids-grafted Water-soluble Chitosan against Drug-resistant Bacteria
Erratum to: Antibacterial Effects of Amino Acids-grafted Water-soluble Chitosan against Drug-resistant Bacteria Open
View article: Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity Open
Several antimicrobial peptides (AMPs) have been discovered, developed, and purified from natural sources and peptide engineering; however, the clinical applications of these AMPs are limited owing to their lack of abundance and side effect…
View article: Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients Open
View article: Antifungal Effect of A Chimeric Peptide Hn-Mc against Pathogenic Fungal Strains
Antifungal Effect of A Chimeric Peptide Hn-Mc against Pathogenic Fungal Strains Open
It is difficult to identify new antifungal agents because of their eukaryotic nature. However, antimicrobial peptides can well differentiate among cell types owing to their variable amino acid content. This study aimed to investigate the a…
View article: Intermediate die profile design for high-precision production of rectangular stainless-steel bars via new tandem drawing process
Intermediate die profile design for high-precision production of rectangular stainless-steel bars via new tandem drawing process Open
View article: Correction to: Long-term Outcome of Angioplasty Using a Wingspan Stent, Post-Stent Balloon Dilation and Aggressive Restenosis Management for Intracranial Arterial Stenosis
Correction to: Long-term Outcome of Angioplasty Using a Wingspan Stent, Post-Stent Balloon Dilation and Aggressive Restenosis Management for Intracranial Arterial Stenosis Open
View article: Anti-Biofilm Effects of Synthetic Antimicrobial Peptides Against Drug-Resistant Pseudomonas aeruginosa and Staphylococcus aureus Planktonic Cells and Biofilm
Anti-Biofilm Effects of Synthetic Antimicrobial Peptides Against Drug-Resistant Pseudomonas aeruginosa and Staphylococcus aureus Planktonic Cells and Biofilm Open
Biofilm-associated infections are difficult to manage or treat as biofilms or biofilm-embedded bacteria are difficult to eradicate. Antimicrobial peptides have gained increasing attention as a possible alternative to conventional drugs to …
View article: Functional Characterization of a Rice Thioredoxin Protein OsTrxm and Its Cysteine Mutant Variant with Antifungal Activity
Functional Characterization of a Rice Thioredoxin Protein OsTrxm and Its Cysteine Mutant Variant with Antifungal Activity Open
Although there are many antimicrobial proteins in plants, they are not well-explored. Understanding the mechanism of action of plant antifungal proteins (AFPs) may help combat fungal infections that impact crop yields. In this study, we ai…
View article: Enhanced Antifungal Activity of Engineered Proteins via Swapping between Thioredoxin H2 and H3
Enhanced Antifungal Activity of Engineered Proteins via Swapping between Thioredoxin H2 and H3 Open
Thioredoxins (Trxs) are proteins that act as antioxidants by facilitating the reduction of other proteins and are highly conserved in all organisms. Plant H-type Trx isoforms have different structures and perform multiple functions. Previo…
View article: Deep Learning-Based Deep Brain Stimulation Targeting and Clinical Applications
Deep Learning-Based Deep Brain Stimulation Targeting and Clinical Applications Open
The accuracy of deep learning-based semantic segmentation may surpass that of previous methods. DBS targeting and its clinical application were made possible using accurate deep learning-based semantic segmentation, which is adaptive to an…
View article: Erratum to: Antibacterial Effects of Amino Acids-grafted Water-soluble Chitosan against Drug-resistant Bacteria
Erratum to: Antibacterial Effects of Amino Acids-grafted Water-soluble Chitosan against Drug-resistant Bacteria Open
View article: Functional Mechanisms Underlying the Antimicrobial Activity of the Oryza sativa Trx-like Protein
Functional Mechanisms Underlying the Antimicrobial Activity of the Oryza sativa Trx-like Protein Open
Plants are constantly subjected to a variety of environmental stresses and have evolved regulatory responses to overcome unfavorable conditions that might reduce or adversely change a plant’s growth or development. Among these, the regulat…
View article: In Reply: Systematic Stereotactic Error Reduction Using a Calibration Technique in Single-Brain-Pass and Multitrack Deep Brain Stimulations
In Reply: Systematic Stereotactic Error Reduction Using a Calibration Technique in Single-Brain-Pass and Multitrack Deep Brain Stimulations Open
To the Editor: We are grateful for the interest in our article.1 Stereotactic accuracy is one of the most important issues in stereotactic neurosurgery and there are various image-guided applications including image-guided manual or roboti…