Natarajan Venkatesan
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View article: Supplementary Figure 13 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 13 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
RNA differential expression in mE180 and GAN edited cell lines
View article: Data from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Data from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Gigaxonin is an E3 ubiquitin ligase that plays a role in cytoskeletal stability. Its role in cancer is not yet clearly understood. Our previous studies of head and neck cancer had identified gigaxonin interacting with p16 for NFκB ubiquiti…
View article: FIGURE 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
FIGURE 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Gigaxonin-mediated regulation of Snail in gene transfected ME180 cells. A, FLAG-Snail and Myc-GAN plasmid DNA cotransfected ME180 cells show higher expression of FLAG and Snail in cells split 48 hours after transfection pointing to …
View article: Supplementary Figure 17 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Subcutaneous xenograft tumor formation in nude (NSG) mice
View article: Supplementary Figure Legends from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Supplementary figure legends
View article: Supplementary Figure 19 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 19 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Ubiquitination assay for GAN binding to Snail and NF-kB
View article: Supplementary Figure 14 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 14 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Snapshot view of exon 8 in ME180 and GAN edited cell lines
View article: Supplementary Figure 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
ME180 and CRISPR-Cas9 clones
View article: Supplementary Figure 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
ME180 and CRISPR-Cas9 clones
View article: Supplementary Figure Legends from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure Legends from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Supplementary figure legends
View article: FIGURE 6 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
FIGURE 6 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Inhibition of mouse lung metastasis with re-expression of gigaxonin. A, Table shows xenograft tumors formation by ME180 cells and lung metastasis by GAN edited clones. ME180 did not form lung metastasis. Greater than 50% reduced met…
View article: Supplementary Table 5 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Table 5 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
GAN gene RT-PCR primers
View article: FIGURE 4 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
FIGURE 4 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Re-expression of gigaxonin leads to reversal of NFκB pathway. A, Re-expression of gigaxonin in GAN edited cells showed an intermediate epithelial morphology with a brighter light transmission than GAN edited cells or control lentivi…
View article: Supplementary Figure 10 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 10 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Synonymous exome SNP and Indel sequences in ME180 and GAN edited cell lines
View article: Supplementary Methods from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Methods from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Supplementary methods
View article: Supplementary Figure 2 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 2 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Morphology of fibroblast and cancer cell lines
View article: FIGURE 4 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
FIGURE 4 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Re-expression of gigaxonin leads to reversal of NFκB pathway. A, Re-expression of gigaxonin in GAN edited cells showed an intermediate epithelial morphology with a brighter light transmission than GAN edited cells or control lentivi…
View article: Supplementary Figure 22 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Figure 22 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Overall survival of head and neck cancer
View article: Supplementary Figure 5 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Representative soft agar colonies of ME180, HeLa, and Siha cell lines
View article: FIGURE 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
FIGURE 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Gigaxonin-mediated regulation of Snail in gene transfected ME180 cells. A, FLAG-Snail and Myc-GAN plasmid DNA cotransfected ME180 cells show higher expression of FLAG and Snail in cells split 48 hours after transfection pointing to …
View article: Supplementary Table 2 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Table 2 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Exon 8 SNP frequency in normal vs tumors
View article: FIGURE 1 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
FIGURE 1 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Association of exon 8 SNP to RNA and protein expression. Relative transcript hits are calculated from GAPDH transcript levels in HeLa cells (164,185 transcripts) and differential cell cycle (ΔCt) expression of GAPDH versus gene of i…
View article: Supplementary Figure 11 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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All non synonymous SNPs in ME180 and GAN edited cell lines
View article: Supplementary Table 8 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Table 8 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Antibody details
View article: Supplementary Figure 15 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Invasion and migration of control and GAN siRNA treated ME180 cells
View article: Supplementary Table 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
Supplementary Table 7 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail Open
Neurodegenerative diseases and cancer
View article: Supplementary Figure 9 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Synonymous exome duplication sequences in ME180 and GAN edited cell lines
View article: Supplementary Methods from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Supplementary methods
View article: Supplementary Figure 6 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Incucyte live cell assay of cisplatin treated ME180 cells
View article: Supplementary Figure 8 from Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail
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Map of lentiviral cloning vector