Young Kee Shin
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View article: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency
Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency Open
View article: 472 A CTLA-4 recycling × TIGIT bispecific antibody enables selective depletion of tumor-infiltrating regulatory T cells
472 A CTLA-4 recycling × TIGIT bispecific antibody enables selective depletion of tumor-infiltrating regulatory T cells Open
View article: 865 ABN202 (αTROP2): A TROP2-targeting IFN-β mutein fusion protein with retained activity in acidic tumor microenvironments and reduced toxicity for an improved therapeutic window
865 ABN202 (αTROP2): A TROP2-targeting IFN-β mutein fusion protein with retained activity in acidic tumor microenvironments and reduced toxicity for an improved therapeutic window Open
View article: CRISPR-Induced NUT Suppression Promotes Differentiation and Enhances Trop2-Targeted Immunocytokine Response in NUT Carcinoma
CRISPR-Induced NUT Suppression Promotes Differentiation and Enhances Trop2-Targeted Immunocytokine Response in NUT Carcinoma Open
NUT carcinoma (NC) is an aggressive malignancy driven by NUTM1 gene rearrangements with limited therapeutic options. Here, we show that direct suppression of NUTM1 using CRISPR/Cas9 induces squamous-like differentiation and upregulates TRO…
View article: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency
Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency Open
A significant challenge of mRNA-based protein replacement therapies is the diminishing efficacy and escalating toxicity associated with repeated dosing of lipid nanoparticles (LNPs). Many existing lipid formulations were originally designe…
View article: P-151 Correlation of iDAScore and PGT-A Outcomes across Age and Embryo grading
P-151 Correlation of iDAScore and PGT-A Outcomes across Age and Embryo grading Open
Study question At What Age and Embryo Grade Does iDAScore Effectively Predict Euploid Embryos? Summary answer Higher mean iDA scores associate with lower genetic abnormalities across all ages, notably in ≥ 41 patients and lower-grade embry…
View article: Differentiation Defect Into <scp>GABAergic</scp> Neurons in Cerebral Organoids From Autism Patients
Differentiation Defect Into <span>GABAergic</span> Neurons in Cerebral Organoids From Autism Patients Open
Objectives Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects social communication and behaviors. While previous studies using animal models have substantially expanded our knowledge about ASD, the lack of an app…
View article: Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1
Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 Open
[This corrects the article on p. 129 in vol. 29, PMID: 39790223.].
View article: Influential Factors on Survival in Laryngeal Cancer and Treatment Modalities Comparison
Influential Factors on Survival in Laryngeal Cancer and Treatment Modalities Comparison Open
Introduction: Laryngeal cancer (LC) is the most common malignancy in otolaryngology, comprising 30–40% of head and neck malignancies. With an increasing incidence worldwide over the past few decades, LC has resulted in substantial strain o…
View article: Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications
Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications Open
Recent advancements in passive wireless sensor technology have significantly extended the application scope of sensing, particularly in challenging environments for monitoring industry and healthcare applications. These systems are equippe…
View article: Correction: c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
Correction: c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer Open
View article: Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1
Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 Open
Prolyl hydroxylase domain 2 (PHD2) is the primary oxygen sensing enzyme involved in hydroxylation of hypoxia-inducible factor (HIF). Under normoxic conditions, PHD2 hydroxylates specific proline residues in HIF-1α and HIF-2α, promoting the…
View article: Design, Screening and Development of Asymmetric siRNAs Targeting the <i>MYC</i> Oncogene in Triple-Negative Breast Cancer
Design, Screening and Development of Asymmetric siRNAs Targeting the <i>MYC</i> Oncogene in Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks hormone receptor and Her2 (ERBB2) expression, leaving chemotherapy as the only treatment option. The urgent need for targeted therapy for TNBC patients has led t…
View article: Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer
Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer Open
View article: Development of Image Collection Method Using YOLO and Siamese Network
Development of Image Collection Method Using YOLO and Siamese Network Open
As we enter the era of big data, collecting high-quality data is very important. However, collecting data by humans is not only very time-consuming but also expensive. Therefore, many scientists have devised various methods to collect data…
View article: Translation Initiation Factor-2S2 (eIF2S2) Contributes to Cervical Carcinogenesis by Inhibiting the TGF-β/SMAD4 Signaling Pathway
Translation Initiation Factor-2S2 (eIF2S2) Contributes to Cervical Carcinogenesis by Inhibiting the TGF-β/SMAD4 Signaling Pathway Open
The deregulation of protein translational machinery and the oncogenic role of several translation initiation factors have been extensively investigated. This study aimed to investigate the role of eukaryotic translation initiation factor 2…
View article: Tailoring Classical Conditioning Behavior in TiO2 Nanowires: ZnO QDs-Based Optoelectronic Memristors for Neuromorphic Hardware
Tailoring Classical Conditioning Behavior in TiO2 Nanowires: ZnO QDs-Based Optoelectronic Memristors for Neuromorphic Hardware Open
Neuromorphic hardware equipped with associative learning capabilities presents fascinating applications in the next generation of artificial intelligence. However, research into synaptic devices exhibiting complex associative learning beha…
View article: c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer Open
View article: Micropyramid Array Bimodal Electronic Skin for Intelligent Material and Surface Shape Perception Based on Capacitive Sensing
Micropyramid Array Bimodal Electronic Skin for Intelligent Material and Surface Shape Perception Based on Capacitive Sensing Open
Developing electronic skins (e‐skins) that are comparable to or even beyond human tactile perception holds significant importance in advancing the process of intellectualization. In this context, a machine‐learning‐motivated micropyramid a…
View article: Advances in advanced <scp>solution‐synthesis‐based</scp> structural materials for tactile sensors and their intelligent applications
Advances in advanced <span>solution‐synthesis‐based</span> structural materials for tactile sensors and their intelligent applications Open
Intelligent applications, with tactile sensors at their core, represent significant advancement in the field of artificial intelligence. However, achieving perception abilities in tactile sensors that match or exceed human skin remains a f…
View article: EP11.03-15 Sarcopenia Is a Poor Predictive Prognostic Factor for Non Small Cell Lung Cancer Patients Who Were Treated with Immune Check Point Inhibitors
EP11.03-15 Sarcopenia Is a Poor Predictive Prognostic Factor for Non Small Cell Lung Cancer Patients Who Were Treated with Immune Check Point Inhibitors Open
View article: Long-term prognostic value of the GenesWell BCT score in Asian women with hormone receptor-positive/HER2-negative early breast cancer
Long-term prognostic value of the GenesWell BCT score in Asian women with hormone receptor-positive/HER2-negative early breast cancer Open
View article: Advanced polymer materials‐based electronic skins for tactile and non‐contact sensing applications
Advanced polymer materials‐based electronic skins for tactile and non‐contact sensing applications Open
Recently, polymer materials have been at the forefront of other materials in building high‐performance flexible electronic skin (e‐skin) devices due to conspicuous advantages including excellent mechanical flexibility, good compatibility, …
View article: RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse
RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse Open
View article: Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner Open
Supplemental Figure Legend
View article: Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner Open
Supplementary Figure 1C. AGS, SW480, and HeLa cells were pretreated with control siRNA (lane 1 and 2) or AURKA siRNA (10 nM, lane 3 and 4) for 48 h, and transfected with the plasmid encoding 6Myc-SMAD4 or empty vector. Cells were collected…
View article: Data from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Data from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner Open
SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which …
View article: Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner Open
Supplementary Figure 1A. HeLa cells were transfected with indicated plasmids as negative controls. Fluorescence images indicated in each panel were captured under fluorescence microscopy (ï?'40) at 18 h after transfection. Scale bar, 5 ÃŽ…
View article: Data from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Data from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner Open
SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which …
View article: Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner Open
Supplementary Figure 1C. AGS, SW480, and HeLa cells were pretreated with control siRNA (lane 1 and 2) or AURKA siRNA (10 nM, lane 3 and 4) for 48 h, and transfected with the plasmid encoding 6Myc-SMAD4 or empty vector. Cells were collected…