Young‐Min Soh
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View article: Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein
Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein Open
SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic. Its high pathogenicity is due to SARS-CoV-2 spike protein (S protein) contacting host-cell receptors. A critical hallmark of COVID-19 is the occurrence of coagulopath…
View article: Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein
Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein Open
SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic. Its high pathogenicity is due to SARS-CoV-2 spike protein (S protein) contacting host-cell receptors. A critical hallmark of COVID-19 is the occurrence of coagulopath…
View article: ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment
ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment Open
The ParAB S system is essential for prokaryotic chromosome segregation. After loading at parS on the genome, ParB (partition protein B) proteins rapidly redistribute to distances of ~15 kilobases from the loading site. It has remained puzz…
View article: Human platelets in presence of SARS-CoV-2 spike protein
Human platelets in presence of SARS-CoV-2 spike protein Open
View article: <i>ParS</i>-independent recruitment of the bacterial chromosome-partitioning protein ParB
<i>ParS</i>-independent recruitment of the bacterial chromosome-partitioning protein ParB Open
The ParAB S system plays an essential role in prokaryotic chromosome segregation. After loading at the parS site on the genome, ParB proteins rapidly redistribute to distances of ~15 kb away from the loading site. It has remained puzzling …
View article: Relief of ParB autoinhibition by <i>parS</i> DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly
Relief of ParB autoinhibition by <i>parS</i> DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly Open
Three-component ParABS systems are widely distributed factors for plasmid partitioning and chromosome segregation in bacteria. ParB acts as adaptor protein between the 16–base pair centromeric parS DNA sequences and the DNA segregation pro…
View article: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding Open
View article: Relief of ParB autoinhibition by parS DNA catalysis and ParB recycling by CTP hydrolysis promote bacterial centromere assembly
Relief of ParB autoinhibition by parS DNA catalysis and ParB recycling by CTP hydrolysis promote bacterial centromere assembly Open
Three-component ParABS systems are widely distributed factors for plasmid partitioning and chromosome segregation in bacteria. ParB protein acts as an adaptor between the 16 bp centromeric parS DNA sequences and the DNA segregation ATPase …
View article: Gradual opening of Smc arms in prokaryotic condensin
Gradual opening of Smc arms in prokaryotic condensin Open
Multi-subunit SMC ATPases control chromosome superstructure apparently by catalyzing a DNA-loop-extrusion reaction. SMC proteins harbor an ABC-type ATPase "head" and a "hinge" dimerization domain connected by a coiled coil "arm." Two arms …
View article: Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection
Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection Open
Eukaryotic cells employ three SMC complexes to control DNA folding and topology. The Smc5/6 complex plays roles in DNA repair and in preventing the accumulation of deleterious DNA junctions. To elucidate how specific features of Smc5/6 gov…
View article: Gradual opening of Smc arms in prokaryotic condensin
Gradual opening of Smc arms in prokaryotic condensin Open
Summary Multi-subunit SMC ATPases control chromosome superstructure apparently by catalyzing a DNA-loop-extrusion reaction. SMC proteins harbor an ABC-type ATPase ‘head’ and a ‘hinge’ dimerization domain connected by a coiled coil ‘arm’. T…
View article: Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast
Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast Open
Correct bioriented attachment of sister chromatids to the mitotic spindle is essential for chromosome segregation. In budding yeast, the conserved protein shugoshin (Sgo1) contributes to biorientation by recruiting the protein phosphatase …
View article: Author response for "A rod conformation of the <i>Pyrococcus furiosus</i> Rad50 coiled coil"
Author response for "A rod conformation of the <i>Pyrococcus furiosus</i> Rad50 coiled coil" Open
View article: A rod conformation of the<i>Pyrococcus furiosus</i>Rad50 coiled coil
A rod conformation of the<i>Pyrococcus furiosus</i>Rad50 coiled coil Open
The Rad50-Mre11 nuclease complex plays a vital role in DNA repair in all domains of life. It recognizes and processes DNA double-strand breaks. Rad50 proteins fold into an extended structure with a ~20-60 nm long coiled coil connecting a g…
View article: Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast
Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast Open
Correct bioriented attachment of sister chromatids to mitotic spindle is essential for chromosome segregation. The conserved protein shugoshin (Sgo1) contributes in budding yeast to biorientation by recruiting the protein phosphatase PP2A-…
View article: Self-organization of <i>parS</i> centromeres by the ParB CTP hydrolase
Self-organization of <i>parS</i> centromeres by the ParB CTP hydrolase Open
CTP hydrolysis organizes chromosomes The bacterial DNA parS centromere recruits the ParB protein to the bacterial chromosome. Soh et al. found that the widespread family of ParB proteins not only bind DNA but also bind and hydrolyze cytidi…
View article: Self-Organization of parS Centromeres by ParB CTP hydrolase
Self-Organization of parS Centromeres by ParB CTP hydrolase Open
Dracala spotting assay, ITC measurements, Malachite Green Assay, in vitro and in vivo crosslinking , DNA loading assay, Sequence alignment used for DCA, Single Molecule Imaging
View article: Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain
Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain Open
Survival and proliferation of cancer cells are often associated with hyperactivity of the serine/threonine kinase, Akt. Herein, we show that prosurvival activity of Akt can be converted into prodeath activity by embedding an Akt recognitio…