Young Do Jung
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View article: Efficacy and safety of analgesic-eluting urethral catheter after urogynecological surgery: a prospective randomized controlled trial
Efficacy and safety of analgesic-eluting urethral catheter after urogynecological surgery: a prospective randomized controlled trial Open
Catheter-related bladder discomfort (CRBD) and urethral pain are frequent issues following urethral catheterization, particularly after urogynecological procedures. This study evaluates the efficacy and safety of a ropivacaine-eluting uret…
View article: Wireless, battery-free multi-axial sensor for augmented reality-assisted monitoring at skin interfaces
Wireless, battery-free multi-axial sensor for augmented reality-assisted monitoring at skin interfaces Open
Demand for augmented reality (AR) technology in the healthcare industry has gradually increased due to its immersive and interactive environment, which enhances the medical staff’s intuitive interpretation of sensing data during surgery, r…
View article: The Effectiveness of Intraperitoneal Carboplatin-Taxane Combination Chemotherapy in Stage 3 Ovarian Cancer
The Effectiveness of Intraperitoneal Carboplatin-Taxane Combination Chemotherapy in Stage 3 Ovarian Cancer Open
Our purpose is comparing the effectiveness of IP and IV chemotherapy in patients with epithelial ovarian cancer (EOC). This is a pilot study for improving protocol of chemotherapy for EOC. Methods: A retrospective, single-center study incl…
View article: Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells
Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells Open
Triptolide, the major component of Chinese herbal medicine Tripterygium wilfordii Hook F, possesses potent anticancer and anti-inflammatory effects. IL-8, a proinflammatory cytokine, is associated with cancer cell proliferation and angioge…
View article: Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells
Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells Open
Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities…
View article: Reactive Oxygen Species and H. pylori Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development
Reactive Oxygen Species and H. pylori Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development Open
Gastric cancer (GC) is the fifth most common cancer worldwide and makes up a significant component of the global cancer burden. Helicobacter pylori (H. pylori) is the most influential risk factor for GC, with the International Agency for R…
View article: State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer
State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer Open
The development of new therapeutic strategies is on the increase for prostate cancer stem cells, owing to current standardized therapies for prostate cancer, including chemotherapy, androgen deprivation therapy (ADT), radiotherapy, and sur…
View article: Bile acids and microbes in metabolic disease
Bile acids and microbes in metabolic disease Open
Bile acids (BAs) serve as physiological detergents that enable the intestinal absorption and transportation of nutrients, lipids and vitamins. BAs are primarily produced by humans to catabolize cholesterol and play crucial roles in gut met…
View article: (-)-Epigallocatechin-3-Gallate Prevents IL-1β-Induced uPAR Expression and Invasiveness via the Suppression of NF-κB and AP-1 in Human Bladder Cancer Cells
(-)-Epigallocatechin-3-Gallate Prevents IL-1β-Induced uPAR Expression and Invasiveness via the Suppression of NF-κB and AP-1 in Human Bladder Cancer Cells Open
(-)-Epigallocatechin-3-O-gallate (EGCG), a primary green tea polyphenol, has powerful iron scavengers, belongs to the family of flavonoids with antioxidant properties, and can be used to prevent cancer. Urokinase-type plasminogen activator…
View article: Editorial: Discovering novel anticancer molecules and revealing the pharmacological mechanism of gastrointestinal carcinoma
Editorial: Discovering novel anticancer molecules and revealing the pharmacological mechanism of gastrointestinal carcinoma Open
EDITORIAL article Front. Pharmacol., 10 October 2022Sec. Gastrointestinal and Hepatic Pharmacology Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1047705
View article: Sulforaphane Regulates eNOS Activation and NO Production via Src-Mediated PI3K/Akt Signaling in Human Endothelial EA.hy926 Cells
Sulforaphane Regulates eNOS Activation and NO Production via Src-Mediated PI3K/Akt Signaling in Human Endothelial EA.hy926 Cells Open
Sulforaphane (SFN) is a naturally occurring isothiocyanate that is abundant in many cruciferous vegetables, such as broccoli and cauliflower, and it has been observed to exert numerous biological activities. In the present study, we invest…
View article: Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells
Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells Open
Sulforaphane, a natural phytochemical compound found in various cruciferous vegetables, has been discovered to present anti-cancer properties. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in gastric cancer metastasis. However, t…
View article: Hepatic Encephalopathy and Melatonin
Hepatic Encephalopathy and Melatonin Open
Hepatic encephalopathy (HE) is a severe metabolic syndrome linked with acute/chronic hepatic disorders. HE is also a pernicious neuropsychiatric complication associated with cognitive decline, coma, and death. Limited therapies are availab…
View article: A cutaneous receptors-mimicking system for real-time and multimodal detection of tactile stimuli
A cutaneous receptors-mimicking system for real-time and multimodal detection of tactile stimuli Open
A human can intuitively perceive and comprehend complicated tactile information, when interacting with objects, owing to the different cutaneous receptors distributed in the fingertip skin. Many research groups have attempted to mimic the …
View article: Piperine Attenuates Lithocholic Acid-Stimulated Interleukin-8 by Suppressing Src/EGFR and Reactive Oxygen Species in Human Colorectal Cancer Cells
Piperine Attenuates Lithocholic Acid-Stimulated Interleukin-8 by Suppressing Src/EGFR and Reactive Oxygen Species in Human Colorectal Cancer Cells Open
Piperine, a natural alkaloidal pungent product present in pepper plants, possesses the properties of anti-inflammatory and anti-metastasis. Lithocholic acid is a monohydroxy-5beta-cholanic acid with an alpha-hydroxy substituent at position…
View article: Primary bile acid activates Egr‑1 expression through the MAPK signaling pathway in gastric cancer
Primary bile acid activates Egr‑1 expression through the MAPK signaling pathway in gastric cancer Open
Bile acids have been linked to pathomechanism and prognosis in various types of cancers. The present study aimed to investigate the effect of bile acids on the molecular change in gastric epithelial cancer cells and to evaluate gastric bil…
View article: PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases
PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases Open
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a potent tumor suppressor that regulates several key cellular processes, including proliferation, survival, genomic integrity, migration, and invasion, via PI3K‐dependent an…
View article: Bioinspired nanoscale hierarchical pillars for extreme superhydrophobicity and wide angular transmittance
Bioinspired nanoscale hierarchical pillars for extreme superhydrophobicity and wide angular transmittance Open
Tailored nanohierarchical pillars on glass surface via multistep colloidal lithography exhibit extreme superhydrophobicity and wide angular transmittance. Nonwetting excellency of hierarchy is evaluated with bouncing number and effective s…
View article: Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells
Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells Open
Micro-RNA-21 (miR-21) is a vital regulator of colorectal cancer (CRC) progression and has emerged as a potential therapeutic target in CRC treatment. Our study using real-time PCR assay found that a secondary bile acid, lithocholic acid (L…
View article: Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System
Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System Open
Cochlear implants (CIs) have become the standard treatment for severe-to-profound sensorineural hearing loss. Conventional CIs have some challenges, such as the use of extracorporeal devices, and high power consumption for frequency analys…
View article: Natural Phytochemicals in Bladder Cancer Prevention and Therapy
Natural Phytochemicals in Bladder Cancer Prevention and Therapy Open
Phytochemicals are natural small-molecule compounds derived from plants that have attracted attention for their anticancer activities. Some phytochemicals have been developed as first-line anticancer drugs, such as paclitaxel and vincristi…
View article: Suppression of Urokinase-Type Plasminogen Activator Receptor by Docosahexaenoic Acid Mediated by Heme Oxygenase-1 in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Human Endothelial Cells
Suppression of Urokinase-Type Plasminogen Activator Receptor by Docosahexaenoic Acid Mediated by Heme Oxygenase-1 in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Human Endothelial Cells Open
Urokinase-type plasminogen activator receptor (uPAR) plays a crucial role in inflammation and tumor metastasis. Docosahexaenoic acid (DHA), a representative omega-3 polyunsaturated fatty acid, has been shown to exhibit anti-inflammatory an…
View article: Moth-EyeMimicking Solid Slippery Glass Surface withIcephobicity, Transparency, and Self-Healing
Moth-EyeMimicking Solid Slippery Glass Surface withIcephobicity, Transparency, and Self-Healing Open
Slippery liquid-infused
porous surfaces (SLIPSs) have been actively
studied to improve the limitations of superhydrophobic (SHP) surfaces,
especially the defects of the nonwetting chemical coating layer and
the weak mechanical robustness o…
View article: Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity
Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity Open
Matrix metalloproteinase-9 (MMP-9) plays a crucial role in cell invasion and cancer metastasis. In this study, we showed that cholic acid (CA), a major primary bile acid, can induce MMP-9 expression in colon cancer HT29 and SW620 cells. CA…
View article: Lysophosphatidic Acid Upregulates Recepteur D’origine Nantais Expression and Cell Invasion via Egr-1, AP-1, and NF-κB Signaling in Bladder Carcinoma Cells
Lysophosphatidic Acid Upregulates Recepteur D’origine Nantais Expression and Cell Invasion via Egr-1, AP-1, and NF-κB Signaling in Bladder Carcinoma Cells Open
Muscle invasive bladder carcinoma is a highly malignant cancer with a high mortality rate, due to its tendency to metastasize. The tyrosine kinase recepteur d’origine nantais (RON) promotes bladder carcinoma metastasis. Lysophosphatidic ac…
View article: Prediction of Location of the Parotid Tumors that Cross Over Anatomical Criteria for Facial Nerve on Computed Tomography
Prediction of Location of the Parotid Tumors that Cross Over Anatomical Criteria for Facial Nerve on Computed Tomography Open
Background and Objectives To find more accurate way to determine the location of parotid tumors that cross anatomical criteria for the facial nerve (FN). Subjects and Method Two hundred patients were included in the study and retrospective…
View article: The Effects of Olfactory Training with Intranasal Corticosteroid Spray in Korean Patients with Olfactory Dysfunction
The Effects of Olfactory Training with Intranasal Corticosteroid Spray in Korean Patients with Olfactory Dysfunction Open
Background and Objectives:Olfactory training is an alternative treatment based on modulation of the regeneration process of the olfactory system via repeated exposure to odors.Our study aimed to investigate the impact of olfactory training…