Young‐Hee Nam
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View article: Successful dupilumab treatment in a patient with severe dermatitis following allogenic hematopoietic stem cell transplantation
Successful dupilumab treatment in a patient with severe dermatitis following allogenic hematopoietic stem cell transplantation Open
Background Allogenic hematopoietic stem cell transplantation (HSCT) is the optimal treatment of hematologic diseases and various malignancies. Development of allergic disease in a transplant patient has been reported. Case presentations A …
View article: Clinical characteristics and risk factors for escalation to anaphylaxis from non‐severe drug hypersensitivity reaction
Clinical characteristics and risk factors for escalation to anaphylaxis from non‐severe drug hypersensitivity reaction Open
Background Drug hypersensitivity reaction (DHR) poses significant challenges in clinical practice, with some patients experiencing more severe reactions upon re‐exposure. Understanding the factors contributing to escalation into more sever…
View article: Biomarkers of type 2 inflammation as predictors of response to biologics for severe eosinophilic asthma
Biomarkers of type 2 inflammation as predictors of response to biologics for severe eosinophilic asthma Open
Background The relationship between pre-treatment levels of blood eosinophil count (BEC), fractional exhaled nitric oxide ( F ENO ) and sputum eosinophils (Sp-EOS) and treatment response to monoclonal antibodies (mAbs) in severe eosinophil…
View article: Impact of Biologics on Nasal Symptoms in Severe Asthmatics: Findings From the PRISM Study
Impact of Biologics on Nasal Symptoms in Severe Asthmatics: Findings From the PRISM Study Open
Dupilumab demonstrates a significant improvement not only in total SNOT-22 scores but also in the extranasal rhinological, physiologic, and sleep dysfunction domain scores compared to conventional or anti-IL-5 treatment in patients with se…
View article: Siglec-8 as a Biomarker for Predicting Anti-IL-5 Response in Severe Asthma
Siglec-8 as a Biomarker for Predicting Anti-IL-5 Response in Severe Asthma Open
ClinicalTrials.gov Identifier: NCT05164939.
View article: Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea
Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea Open
The prevalence of fungal sensitization in severe asthma is approximately twice as high as in non-severe asthma. Early diagnosed asthma may be a risk factor for SAFS, and patients with SAFS face a greater burden of additional treatment comp…
View article: Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study
Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study Open
QoL was worse in severe asthma than in mild-to-moderate asthma and other chronic diseases. T2 biologics equally improved QoL in patients with severe asthma.
View article: The Effect of Depression on Smartphone Addiction: The Medicating Effects of Interpersonal Problem in Korean Adolescents
The Effect of Depression on Smartphone Addiction: The Medicating Effects of Interpersonal Problem in Korean Adolescents Open
Introduction Problematic smartphone use is twice as common among teenagers as it is among adults. Smartphone addiction is associated with anxiety, depression, attention deficit disorder, impulsivity, and sleep problems, among other issues.…
View article: Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort
Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort Open
Since ACOs with T2-high profiles may have lower lung function and more frequent exacerbations, T2-high specific therapies, such as biologics, should be actively considered in T2-high ACO patients.
View article: Characteristics of Severe Asthma in the Elderly: Observations From the Korean Severe Asthma Registry (KoSAR)
Characteristics of Severe Asthma in the Elderly: Observations From the Korean Severe Asthma Registry (KoSAR) Open
SA in the elderly is characterized by lower lung function, less type 2-low airway inflammation, and comorbidity with COPD. These findings are being taken into consideration in the management of elderly patients with SA in real-world clinic…
View article: Leucovorin-induced Hypersensitivity Reaction in a Patient with Metastatic Colorectal Cancer Treated with Cetuximab Plus FOLFOX Chemotherapy: A Case Report
Leucovorin-induced Hypersensitivity Reaction in a Patient with Metastatic Colorectal Cancer Treated with Cetuximab Plus FOLFOX Chemotherapy: A Case Report Open
The FOLFOX regimen (combination of leucovorin, 5-fluorouracil, and oxaliplatin) is the first-line treatment for high-risk stage 2 and 3 colorectal cancer patients. While hypersensitivity reactions (HSRs) caused by oxaliplatin are commonly …
View article: A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study
A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study Open
Biologics treatment response patterns in patients with ACO and asthma were comparable, suggesting that biologics should be actively considered for ACO patients as well.
View article: A Study on the Factors and Prediction Model of Triple-Negative Breast Cancer for Public Health Promotion
A Study on the Factors and Prediction Model of Triple-Negative Breast Cancer for Public Health Promotion Open
This study was conducted to identify the risk causes and predictive models based on the clinical features of patients with breast cancer classified as triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBCs) u…
View article: A 43-Year-Old Man with Abdominal Pain and Diarrhea for 2 Months
A 43-Year-Old Man with Abdominal Pain and Diarrhea for 2 Months Open
Hypereosinophilic syndrome (HES) is a heterogeneous group of rare disorders characterized by blood and tissue eosinophilia accompanied by eosinophil-driven tissue damage and dysfunction. Clinical manifestations of HES are highly variable, …
View article: Can we apply biomarkers in the management of non-steroidal anti-inflammatory drug exacerbated respiratory disease?
Can we apply biomarkers in the management of non-steroidal anti-inflammatory drug exacerbated respiratory disease? Open
Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by adult-onset asthma, chronic rhinosinusitis with nasal polyps (CRSwNPs), and aspirin/NSAID hypersensitivity, presenting recurrent asthma…
View article: Nonepisodic angioedema with eosinophilia after COVID-19 vaccination: a case successfully treated with reslizumab
Nonepisodic angioedema with eosinophilia after COVID-19 vaccination: a case successfully treated with reslizumab Open
Background Angioedema with eosinophilia (AE) is a rare allergic disease classified as episodic or nonepisodic. AE is characterized by angioedema, urticaria, fever, weight gain, and eosinophilia, but its etiology and pathogenesis have not y…
View article: Idiopathic Hypereosinophilia: A Multicenter Retrospective Analysis
Idiopathic Hypereosinophilia: A Multicenter Retrospective Analysis Open
Corticosteroid treatment is generally effective and well tolerated by patients with iHES. Some patients with HEus are treated with corticosteroids in clinical practice. Extensive research is needed to establish a standardized management gu…
View article: Clinical predictors of treatment response to tiotropium add-on therapy in adult asthmatic patients: From multicenter real-world cohort data in Korea
Clinical predictors of treatment response to tiotropium add-on therapy in adult asthmatic patients: From multicenter real-world cohort data in Korea Open
The results of this study suggest that tiotropium add-on for uncontrolled asthma with ICS-LABA would be more effective in patients with positive BDR or ACO. Additionally, an increase in FEV1 following tiotropium may predict a lower risk of…
View article: HLA‐A*24:02 increase the risk of allopurinol‐induced drug reaction with eosinophilia and systemic symptoms in HLA‐B*58:01 carriers in a Korean population; a multicenter cross‐sectional case‐control study
HLA‐A*24:02 increase the risk of allopurinol‐induced drug reaction with eosinophilia and systemic symptoms in HLA‐B*58:01 carriers in a Korean population; a multicenter cross‐sectional case‐control study Open
Background HLA‐B*58:01 is a well‐known risk factor for allopurinol‐induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA‐B*58:01 carriers suffer SCARs after taking allopurinol. The aim of this study was to inv…
View article: The Psychological Relieving Effect of Drug Provocation Test in Drug Hypersensitivity
The Psychological Relieving Effect of Drug Provocation Test in Drug Hypersensitivity Open
DPT may reduce the psychological burden in patients with drug hypersensitivity, especially in those without anaphylaxis.
View article: The burden of symptomatic patients with chronic spontaneous urticaria: a real-world study in Korea
The burden of symptomatic patients with chronic spontaneous urticaria: a real-world study in Korea Open
Background/Aims: Chronic spontaneous urticaria (CSU) poses a considerable burden both on the quality of life (QoL) of individual patients and on healthcare systems. Real‑world data evaluating the disease burden of CSU are limited in this c…
View article: Chronic obstructive lung disease after ammonia inhalation burns: a report of two cases
Chronic obstructive lung disease after ammonia inhalation burns: a report of two cases Open
Anhydrous ammonia is a commonly used chemical in industry. Ammonia gas inhalation causes thermal injuries and alkali burns in the airway and lung parenchyma. Previous case reports have stated that respiratory sequelae after acute ammonia i…
View article: Emerging Biomarkers Beyond Leukotrienes for the Management of Nonsteroidal Anti-inflammatory Drug (NSAID)-Exacerbated Respiratory Disease
Emerging Biomarkers Beyond Leukotrienes for the Management of Nonsteroidal Anti-inflammatory Drug (NSAID)-Exacerbated Respiratory Disease Open
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is a unique condition characterized by aspirin/NSAID hypersensitivity, adult-onset asthma, and/or chronic rhinosinusitis with nasal polyps. Arachidonic acid…