Youngil Koh
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View article: Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity (Adv. Sci. 41/2025)
Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity (Adv. Sci. 41/2025) Open
View article: Clonal Hematopoiesis in Human Disease: An Essential Immunologic Phenomenon in Aging Populations
Clonal Hematopoiesis in Human Disease: An Essential Immunologic Phenomenon in Aging Populations Open
Clonal hematopoiesis denotes a condition involving acquired genetic mutations in hematopoietic stem cells, and is recognized as precancerous lesion for hematologic malignancy (e.g., myelodysplastic syndrome or acute myeloid leukemia). Rece…
View article: Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity
Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity Open
Non‐apoptotic cell death have emerged as promising strategies to overcome apoptotic resistance in cancer therapy. We suggest a hybrid gene delivery platform integrating adeno‐associated virus (AAV)‐mediated expression of receptor‐interacti…
View article: Influence of lifestyle risk factors and genetic predisposition on metabolic syndrome risk in Korean adults
Influence of lifestyle risk factors and genetic predisposition on metabolic syndrome risk in Korean adults Open
Metabolic syndrome (MetS) is a major risk factor for cardiovascular and chronic diseases. This study evaluated how genetic predisposition and lifestyle factors contribute to MetS risk. We analysed data from 4,987 Koreans aged ≥ 40 years wi…
View article: Azacitidine followed by R-GDP in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma: preliminary results from a multicenter, phase II study
Azacitidine followed by R-GDP in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma: preliminary results from a multicenter, phase II study Open
Background: Epigenetic priming prior to chemotherapy represents a promising treatment strategy for refractory or relapsed diffuse large B-cell lymphoma (R/R DLBCL). We conducted a phase II trial to evaluate the efficacy and safety of azaci…
View article: 618 | SEQUENTIAL BTK INHIBITOR THERAPY IN RELAPSED/REFRACTORY MANTLE CELL LYMPHOMA: REAL‐WORLD OUTCOMES AND ATTRITION RATES—FINAL REPORT FROM THE ASIA‐PACIFIC REGISTRY
618 | SEQUENTIAL BTK INHIBITOR THERAPY IN RELAPSED/REFRACTORY MANTLE CELL LYMPHOMA: REAL‐WORLD OUTCOMES AND ATTRITION RATES—FINAL REPORT FROM THE ASIA‐PACIFIC REGISTRY Open
View article: 104 | A GLOBAL PHASE 1B STUDY OF JNJ‐90014496, A CD19/CD20 BI‐SPECIFIC CHIMERIC ANTIGEN RECEPTOR (CAR) T‐CELL THERAPY, IN RELAPSED/REFRACTORY (R/R) LARGE B‐CELL LYMPHOMA (LBCL)
104 | A GLOBAL PHASE 1B STUDY OF JNJ‐90014496, A CD19/CD20 BI‐SPECIFIC CHIMERIC ANTIGEN RECEPTOR (CAR) T‐CELL THERAPY, IN RELAPSED/REFRACTORY (R/R) LARGE B‐CELL LYMPHOMA (LBCL) Open
View article: Real-world effectiveness of ixazomib, lenalidomide and dexamethasone in Asians with relapsed/refractory multiple myeloma
Real-world effectiveness of ixazomib, lenalidomide and dexamethasone in Asians with relapsed/refractory multiple myeloma Open
View article: Comprehensive clinico‐genetic analysis reveals prognostic factors of blastic plasmacytoid dendritic cell neoplasm
Comprehensive clinico‐genetic analysis reveals prognostic factors of blastic plasmacytoid dendritic cell neoplasm Open
View article: Real-world outcomes of maintenance therapy post-autologous stem cell transplantation in newly diagnosed multiple myeloma
Real-world outcomes of maintenance therapy post-autologous stem cell transplantation in newly diagnosed multiple myeloma Open
Despite practical limitations, maintenance therapy after ASCT demonstrated a gain in PFS in the real world, and there was no clear increase in the risk of secondary malignancy. Therefore, it may be prudent to consider implementing maintena…
View article: Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication
Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication Open
The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance…
View article: Real-World Effectiveness and Safety of Intravenous Daratumumab in Patients with Multiple Myeloma: A Multicenter, Observational Study from Korea
Real-World Effectiveness and Safety of Intravenous Daratumumab in Patients with Multiple Myeloma: A Multicenter, Observational Study from Korea Open
Purpose Daratumumab is a novel, first-in-class monoclonal antibody approved for use as monotherapy and in combination with other treatments for patients with multiple myeloma (MM). The aim of this observational study was to evaluate the ef…
View article: Phase II trial of imatinib mesylate in patients with <i>PDGFRA/B</i> ‐negative hypereosinophilic syndrome
Phase II trial of imatinib mesylate in patients with <i>PDGFRA/B</i> ‐negative hypereosinophilic syndrome Open
Summary The role of imatinib in PDGFRA/B ‐negative hypereosinophilic syndromes (HES) is controversial because of the heterogeneity of HES and the scarcity of prospective studies. We conducted a phase II clinical trial to evaluate the effic…
View article: Machine-learning-based predictive classifier for bone marrow failure syndrome using complete blood count data
Machine-learning-based predictive classifier for bone marrow failure syndrome using complete blood count data Open
View article: Parkinson’s disease is associated with clonal hematopoiesis with TET2 mutation
Parkinson’s disease is associated with clonal hematopoiesis with TET2 mutation Open
View article: Unraveling the impact of lysosomal dysfunction on myeloproliferative neoplasm
Unraveling the impact of lysosomal dysfunction on myeloproliferative neoplasm Open
Background Lysosomal dysfunction (LD) impacts cytokine regulation, inflammation, and immune responses, influencing the development and progression of cancer. Inflammation is implicated in the pathogenesis of myeloproliferative neoplasm (MP…
View article: Impact of Clonal Hematopoiesis on the Carcinogenic Process of Multiple Myeloma
Impact of Clonal Hematopoiesis on the Carcinogenic Process of Multiple Myeloma Open
Clonal hematopoiesis (CH), a phenomenon linked to aging, correlates with inflammation and myeloid malignancies. Here, we explore the interaction of CH, with terminally differentiated lymphoid malignancy, and multiple myeloma (MM). Analysis…
View article: Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia
Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia Open
B-cell-lymphoma-2 (BCL2) homology-3 (BH3) mimetics are inhibitors of protein–protein interactions (PPIs) that saturate anti-apoptotic proteins in the BCL2 family to induce apoptosis in cancer cells. Despite the success of the BH3-mimetic A…
View article: Dual T-cell depletion with individually tailored anti-thymocyte globulin and attenuated dose of post-transplant cyclophosphamide in haploidentical peripheral stem cell transplantation
Dual T-cell depletion with individually tailored anti-thymocyte globulin and attenuated dose of post-transplant cyclophosphamide in haploidentical peripheral stem cell transplantation Open
View article: Safety of Extended Pirtobrutinib Exposure in Relapsed and/or Refractory B-Cell Malignancies
Safety of Extended Pirtobrutinib Exposure in Relapsed and/or Refractory B-Cell Malignancies Open
Introduction: Pirtobrutinib, a highly selective, noncovalent (reversible) Bruton tyrosine kinase inhibitor, has demonstrated promising efficacy in B-cell malignancies and is associated with low rates of discontinuation and do…
View article: Pursuing dynamics of minimal residual leukemic subclones in relapsed and refractory acute myeloid leukemia during conventional therapy
Pursuing dynamics of minimal residual leukemic subclones in relapsed and refractory acute myeloid leukemia during conventional therapy Open
Background Acute myeloid leukemia (AML) is characterized by clonal heterogeneity, leading to frequent relapses and drug resistance despite intensive clinical therapy. Although AML's clonal architecture has been addressed in many studies, p…
View article: Combination of acalabrutinib with lenalidomide and rituximab in relapsed/refractory aggressive B-cell non-Hodgkin lymphoma: a single-arm phase II trial
Combination of acalabrutinib with lenalidomide and rituximab in relapsed/refractory aggressive B-cell non-Hodgkin lymphoma: a single-arm phase II trial Open
Potential synergism between Bruton’s tyrosine kinase (BTK) inhibitor and lenalidomide in treating aggressive B-cell lymphoma has been suggested. Here, the authors report a single-arm phase II clinical trial of combination of acalabrutinib,…
View article: Real-world incidence and risk factors of bortezomib-related cardiovascular adverse events in patients with multiple myeloma
Real-world incidence and risk factors of bortezomib-related cardiovascular adverse events in patients with multiple myeloma Open
View article: Impact of clonal haematopoiesis on atherosclerotic cardiovascular disease according to low-density lipoprotein cholesterol levels in general population
Impact of clonal haematopoiesis on atherosclerotic cardiovascular disease according to low-density lipoprotein cholesterol levels in general population Open
Aims Clonal haematopoiesis of indeterminate potential (CHIP), defined as a clonal expansion of age-related recurrent somatic mutations, has recently emerged as a novel cardiovascular risk factor. However, the precise role of CHIP in the de…
View article: Clonal Hematopoiesis of Indeterminate Potential Is Associated with Current Smoking Status and History of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease
Clonal Hematopoiesis of Indeterminate Potential Is Associated with Current Smoking Status and History of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease Open
Background: There is limited data regarding the clinical outcomes of clonal hematopoiesis of indeterminate potential (CHIP) in patients with chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the clinical significan…
View article: Lenalidomide as a treatment for patients with AL amyloidosis and cardiac involvement
Lenalidomide as a treatment for patients with AL amyloidosis and cardiac involvement Open
View article: A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation
A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation Open
Objectives To prove our hypothesis that acyclovir prophylaxis in autologous hematopoietic stem cell transplantation (AHSCT) recipients with hematologic malignancies (HM) reduces the incidence of chemotherapy-induced oral mucositis (CIOM) b…
View article: Pre-operative clonal hematopoiesis is related to adverse outcome in lung cancer after adjuvant therapy
Pre-operative clonal hematopoiesis is related to adverse outcome in lung cancer after adjuvant therapy Open
Background Clonal hematopoiesis (CH) frequently progresses after chemotherapy or radiotherapy. We evaluated the clinical impact of preoperative CH on the survival outcomes of patients with non-small cell lung cancer (NSCLC) who underwent s…
View article: Genetic risk factors for bortezomib-induced peripheral neuropathy in an Asian population: A genome-wide association study in South Korea
Genetic risk factors for bortezomib-induced peripheral neuropathy in an Asian population: A genome-wide association study in South Korea Open
Bortezomib-induced peripheral neuropathy (BIPN) poses a challenge in multiple myeloma (MM) treatment. Genetic factors play a key role in BIPN susceptibility, but research has predominantly focused on Caucasian populations. This research ex…
View article: Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma
Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma Open