Youngran Park
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View article: Safety and non-inferiority of multidose and single-dose vial formulations of EuTCV Vi-CRM197 versus Typbar TCV in healthy participants in Kenya and Senegal: a multicentre, observer-blind, randomised, phase 3 study
Safety and non-inferiority of multidose and single-dose vial formulations of EuTCV Vi-CRM197 versus Typbar TCV in healthy participants in Kenya and Senegal: a multicentre, observer-blind, randomised, phase 3 study Open
For the French translation of the abstract see Supplementary Materials section.
View article: SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production
SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production Open
The SARS-CoV-2 genome encodes 16 nonstructural proteins (Nsps), with Nsp2 being the least conserved and understood. This study highlights a crucial role for Nsp2 in the early phase of the viral life cycle, particularly its interaction with…
View article: SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases
SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases Open
Abnormal innate immune response is a prominent feature underlying autoimmune diseases. One emerging factor driving dysregulated immune activation is cytosolic mitochondrial double-stranded RNAs (mt-dsRNAs). However, the mechanism by which …
View article: SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation
SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation Open
SUMMARY The abnormal innate immune response is a prominent feature underlying autoimmune diseases. One emerging factor that can trigger dysregulated immune activation is cytosolic mitochondrial double-stranded RNAs (mt-dsRNAs). However, th…
View article: Supplementary Figures and Methods from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Supplementary Figures and Methods from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
Supplementary Figures and Methods
View article: Supplementary Figures and Methods from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Supplementary Figures and Methods from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
Supplementary Figures and Methods
View article: Data from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Data from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
Purpose:Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin remodeling complex, are detected in various types of human malignancies. Loss of ARID1A compromises DNA damage repair. The induced DNA damage burden may…
View article: Supplementary Table 1 from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Supplementary Table 1 from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
In vivo phosphoproteome
View article: Supplementary Table 1 from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Supplementary Table 1 from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
In vivo phosphoproteome
View article: Data from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Data from Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
Purpose:Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin remodeling complex, are detected in various types of human malignancies. Loss of ARID1A compromises DNA damage repair. The induced DNA damage burden may…
View article: Effect of Intersection Angle of Input Channels in Droplet Generators
Effect of Intersection Angle of Input Channels in Droplet Generators Open
In this paper, we studied the effects of the intersection angle between the inlet channels on the droplet diameter using a COMSOL Multiphysics® simulation. We employed the level-set method to study the droplet generation process inside a m…
View article: The SARS-CoV-2 RNA interactome
The SARS-CoV-2 RNA interactome Open
SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its ability to repurpose host RNA-binding proteins (RBPs) to form its own RNA interactome. Here, we developed and applied a robust ribonucleoprotein capture protocol to uncov…
View article: Suppression of Inflammation, Osteoclastogenesis and Bone Loss by PZRAS Extract
Suppression of Inflammation, Osteoclastogenesis and Bone Loss by PZRAS Extract Open
Panax ginseng has a wide range of activities including a neuroprotective effect, skin protective effects, enhanced DNA repairing, anti-diabetic activity, and protective effects against vascular inflammation. In the present study, we sought…
View article: Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue.
Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue. Open
The sinus node (SN) is located at the apex of the cardiac conduction system, and SN dysfunction (SND)-characterized by electrical remodeling-is generally attributed to idiopathic fibrosis or ischemic injuries in the SN. SND is associated w…
View article: Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy Open
Purpose: Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin remodeling complex, are detected in various types of human malignancies. Loss of ARID1A compromises DNA damage repair. The induced DNA damage burden ma…
View article: DIPG-34. A HUMAN NEURAL STEM CELL DIPG MODEL IDENTIFIES THE RELATIVE CONTRIBUTION OF DIFFERENT ONCOGENIC ELEMENTS TO INVASIVE MALIGNANT TRANSFORMATION
DIPG-34. A HUMAN NEURAL STEM CELL DIPG MODEL IDENTIFIES THE RELATIVE CONTRIBUTION OF DIFFERENT ONCOGENIC ELEMENTS TO INVASIVE MALIGNANT TRANSFORMATION Open
Nearly 80% of Diffuse Intrinsic Pontine Glioma (DIPG) harbor H3K27M mutation which is inversely correlated with reduced survival, and 60% of H3K27M mutant cells are associated with TP53 mutation. However, it is unclear how those mutations …
View article: Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells
Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells Open
Epithelial-mesenchymal transition (EMT) is a critical process that occurs during cancer progression, and cancer stem cells have been shown to acquire the EMT phenotype. Myeloid cell leukemia-1 (Mcl-1) has been implicated in cancer progress…
View article: Effects of Environmental and Human Constructs on E-Learning Effectiveness in Online University Settings
Effects of Environmental and Human Constructs on E-Learning Effectiveness in Online University Settings Open
The purpose of the research was to understand effects of environmental and human constructs on the success of e-learning in an online university in Korea. The participants of the study completed an online course entitled “Foundations of On…
View article: Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-κB Signaling in HCT116 Human Colorectal Cancer Cells
Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-κB Signaling in HCT116 Human Colorectal Cancer Cells Open
Combination treatment with PT and balsalazide may offer an effective strategy for the induction of apoptosis in HCT116 cells.