Yun‐Long Wu
YOU?
Author Swipe
View article: CCDC 2494618: Experimental Crystal Structure Determination
CCDC 2494618: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2415731: Experimental Crystal Structure Determination
CCDC 2415731: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A trojan horse selenium-containing polymer for protective co-delivery of Fe(II) and cisplatin to boost chemo-ferroptosis synergy via GSH-triggered ROS storm
A trojan horse selenium-containing polymer for protective co-delivery of Fe(II) and cisplatin to boost chemo-ferroptosis synergy via GSH-triggered ROS storm Open
Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, is critically influenced by ferrous ions (Fe2+) and hydrogen peroxide (H2O2). However, the inherent instability of Fe2+ and insufficient levels of end…
View article: Predicting Axillary Lymph Node Metastasis in Breast Cancer Using Ultrasound and Machine Learning with SHAP
Predicting Axillary Lymph Node Metastasis in Breast Cancer Using Ultrasound and Machine Learning with SHAP Open
The Gradient Boosting model with SHAP provides accurate, interpretable ALN metastasis prediction, supporting noninvasive risk stratification and personalized breast cancer management.
View article: Polarization image defogging based on the dark channel principle and multi-scale image fusion
Polarization image defogging based on the dark channel principle and multi-scale image fusion Open
To enhance the recovery capability of the polarization defogging algorithm for foggy scenes, a polarization image defogging algorithm founded upon the dark channel principle and multi-scale fusion is put forth. Initially, the atmospheric l…
View article: METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance
METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance Open
In summary, we found that METTL16-mediated GPX4 modification promoted the proliferation and AZD-9291 resistance of NSLCL by inhibiting ferroptosis activity. Our study is expected to provide a novel insight and potential therapeutic target …
View article: Single‐component cationic polyethylenimine thermogel for sustained and localized gene delivery to combat multi‐drug resistant cancer
Single‐component cationic polyethylenimine thermogel for sustained and localized gene delivery to combat multi‐drug resistant cancer Open
Multi‐drug resistant cancer cells with over‐expression of Bcl2 anti‐apoptotic proteins can be effectively killed by transfecting them with Nur77 transcription factor (pNur77). Previous attempts are generally therapeutically unsatisfactory …
View article: Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation
Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation Open
Periodontitis is a chronic inflammatory disease characterized by hypoxia, excessive oxidative stress, and immune dysregulation, leading to tissue destruction and bone resorption. Although antioxidants can reduce ROS and inflammation, most …
View article: OpSecureCam: optically enhanced secure camera via an engineering point spread function
OpSecureCam: optically enhanced secure camera via an engineering point spread function Open
Photoelectric imaging systems usually pursue a small-sized point spread function (PSF) to acquire high-quality images, but it also poses safety hazards for the camera in certain scenarios. For instance, ultrahigh intensity light focused on…
View article: High-efficiency antioxidant ROS-responsive thermosensitive hydrogel encapsulated Fenofibrate for the treatment of corneal neovascularization
High-efficiency antioxidant ROS-responsive thermosensitive hydrogel encapsulated Fenofibrate for the treatment of corneal neovascularization Open
Corneal neovascularization (CNV) has become one of the common blinding ocular diseases recognized worldwide, affecting millions of people every year. Numerous studies have shown that oxidative stress and inflammation are important factors …
View article: ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation
ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation Open
Hypoxia, inflammatory response and pathogen (bacterial or viral) infection are the three main factors that lead to death in patients with acute lung injury (ALI). Among them, hypoxia activates the expression of HIF‐1α, further exacerbating…
View article: Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy
Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy Open
Reducing L‐lactate levels in tumors is crucial for alleviating immunosuppression and enhancing treatment efficacy. Recently, bacteria have great potential in improving lactate levels in the tumor microenvironment due to their physiological…
View article: RASGEF1C as a novel prognostic biomarker for LUAD
RASGEF1C as a novel prognostic biomarker for LUAD Open
Lung adenocarcinoma (LUAD) is a common histologic lung cancer with high morbidity and mortality, and most patients have distant metastases at diagnosis. RasGEF Domain Family Member 1C (RASGEF1C) could regulated Alzheimer's disease. However…
View article: Learned phase mask to protect camera under laser irradiation
Learned phase mask to protect camera under laser irradiation Open
The electro-optical imaging system works under focus conditions for clear imaging. However, under unexpected laser irradiation, the focused light with extremely high intensity can easily damage the imaging sensor, resulting in permanent de…
View article: Morphologic, cytometric, quantitative transcriptomic and functional characterisation provide insights into the haemocyte immune responses of Pacific abalone (Haliotis discus hannai)
Morphologic, cytometric, quantitative transcriptomic and functional characterisation provide insights into the haemocyte immune responses of Pacific abalone (Haliotis discus hannai) Open
In recent years, the abalone aquaculture industry has been threatened by the bacterial pathogens. The immune responses mechanisms underlying the phagocytosis of haemocytes remain unclear in Haliotis discus hannai . It is necessary to inves…
View article: Color-polarization synergistic target detection method considering shadow interference
Color-polarization synergistic target detection method considering shadow interference Open
Aiming at the problem of shadow interference in UAV's ground reconnaissance, a color and polarization synergistic target detection method is proposed for anti-shadow interference, based on the influence of two physical characteristics (wav…
View article: CCDC 2303414: Experimental Crystal Structure Determination
CCDC 2303414: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Thermosensitive Polyhedral Oligomeric Silsesquioxane Hybrid Hydrogel Enhances the Antibacterial Efficiency of Erythromycin in Bacterial Keratitis
Thermosensitive Polyhedral Oligomeric Silsesquioxane Hybrid Hydrogel Enhances the Antibacterial Efficiency of Erythromycin in Bacterial Keratitis Open
Bacterial keratitis is a serious ocular infection that can impair vision or even cause blindness. The clinical use of antibiotics is limited due to their low bioavailability and drug resistance. Hence, there is a need to develop a novel dr…
View article: Recent advances in biomaterial designs for assisting CAR-T cell therapy towards potential solid tumor treatment
Recent advances in biomaterial designs for assisting CAR-T cell therapy towards potential solid tumor treatment Open
Advances in functional biomaterial designs for assisting CAR-T therapy against solid tumors.
View article: Combined activation of artificial and natural ion channels for disrupting mitochondrial ion homeostasis towards effective postoperative tumor recurrence and metastasis suppression
Combined activation of artificial and natural ion channels for disrupting mitochondrial ion homeostasis towards effective postoperative tumor recurrence and metastasis suppression Open
Rationale: Pharmacological targeting of mitochondrial ion channels is developing as a new direction in cancer therapy. The opening or closing of these channels can impact mitochondrial function and structure by interfering with intracellul…
View article: Non-Invasive Self-Adaptive Information States’ Acquisition inside Dynamic Scattering Spaces
Non-Invasive Self-Adaptive Information States’ Acquisition inside Dynamic Scattering Spaces Open
Pushing the information states’ acquisition efficiency has been a long-held goal to reach the measurement precision limit inside scattering spaces. Recent studies have indicated that maximal information states can be attained through engin…
View article: Non-invasive self-adaptive information states acquisition inside dynamic scattering spaces
Non-invasive self-adaptive information states acquisition inside dynamic scattering spaces Open
Pushing the information states acquisition efficiency has been a long-held goal to reach the measurement precision limit inside scattering spaces. Recent studies point out that the maximum information states can be achieved by engineered m…
View article: Mitochondrial Artificial K<sup>+</sup> Channel Construction Using MPTPP@5F8 Nanoparticles for Overcoming Cancer Drug Resistance via Disrupting Cellular Ion Homeostasis
Mitochondrial Artificial K<sup>+</sup> Channel Construction Using MPTPP@5F8 Nanoparticles for Overcoming Cancer Drug Resistance via Disrupting Cellular Ion Homeostasis Open
Mitochondrial potassium ion channels have become a promising target for cancer therapy. However, in malignant tumors, their low expression or inhibitory regulation typically leads to undesired cancer therapy, or even induces drug resistanc…
View article: Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties Open
The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellen…