Youqiang Ke
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Author Swipe
View article: Gene Editing Technique: Homologue Recombination, Antisense mRNA, RNAi, Site-Directed Mutagenesis, and CRISPR/Cas9
Gene Editing Technique: Homologue Recombination, Antisense mRNA, RNAi, Site-Directed Mutagenesis, and CRISPR/Cas9 Open
Since the 1970s, molecular scientists have been searching for methods to modify DNA via biological repair processes.Thus, they would be able to fix genetic mutations or introduce new functions into the genome.In order to accomplish this go…
View article: Gene Editing Technique: Homologue Recombination, Antisense mRNA, RNAi, Site-Directed Mutagenesis, and CRISPR/Cas9
Gene Editing Technique: Homologue Recombination, Antisense mRNA, RNAi, Site-Directed Mutagenesis, and CRISPR/Cas9 Open
View article: SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation
SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation Open
SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast …
View article: FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells
FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells Open
Fatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cance…
View article: Experimental Treatment Efficacy of dmrFABP5 on Prostate Cancer Singly or in Combination with Drugs in Use
Experimental Treatment Efficacy of dmrFABP5 on Prostate Cancer Singly or in Combination with Drugs in Use Open
Enzalutamide is a drug used to treat PC. Docetaxel is a drug for chemotherapy for different cancers including prostate cancer (PC). The effectiveness of these drugs in treating castration-resistant prostate cancer (CRPC) is not consistent …
View article: Molecular mechanisms on how FABP5 inhibitors promote apoptosis‐induction sensitivity of prostate cancer cells
Molecular mechanisms on how FABP5 inhibitors promote apoptosis‐induction sensitivity of prostate cancer cells Open
Previous work showed that FABP5 inhibitors suppressed the malignant progression of prostate cancer cells, and this suppression might be achieved partially by promoting apoptosis. But the mechanisms involved were not known. Here, we investi…
View article: Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity Open
These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target.
View article: Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5
Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5 Open
[This corrects the article DOI: 10.18632/oncotarget.16055.].
View article: Inactivated Fatty Acid-Binding Protein 5 (FABP5) is a Suppressor for Prostate Cancer
Inactivated Fatty Acid-Binding Protein 5 (FABP5) is a Suppressor for Prostate Cancer Open
Previous study has suggested that the FABP5-PPARγ-signalling transduction pathway gradually replaces the androgen receptor activated pathway in promoting malignant progression of castration-resistant prostate cancer (CRPC) cells.To interfe…
View article: Fatty acid-binding protein 5 (FABP5)-related signal transduction pathway in castration-resistant prostate cancer cells: a potential therapeutic target
Fatty acid-binding protein 5 (FABP5)-related signal transduction pathway in castration-resistant prostate cancer cells: a potential therapeutic target Open
In this short communication, a novel fatty acid-binding protein 5 (FABP5)-related signal transduction pathway in prostate cancer is reviewed. In castration-resistant prostate cancer (CRPC) cells, the FABP5-related signal transduction pathw…
View article: Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPARγ
Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPARγ Open
Previous study has suggested that the FABP5-PPARγ-signalling transduction pathway gradually replaces the androgen receptor activated pathway in promoting malignant progression of castration-resistant prostate cancer (CRPC) cells. To interf…
View article: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5
Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5 Open
[This corrects the article DOI: 10.18632/oncotarget.16055.].
View article: The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance
The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance Open
In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the possible involvement of other FABPs are rare. Here we first measured the mRNA level…
View article: Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating <i>VEGF</i> via PPAR responsive elements of the promoter
Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating <i>VEGF</i> via PPAR responsive elements of the promoter Open
In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer cells through a FABP5-PPARγ-VEGF signal transduction axis to increase angiogenesis.…
View article: High expression of Fatty Acid‐Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells
High expression of Fatty Acid‐Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells Open
Fatty acid‐binding proteins ( FABP s) are responsible for binding and storing hydrophobic ligands such as long‐chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonst…