Yiyu Lu
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View article: Expression of Concern: Over-expression of microRNA-758 inhibited proliferation, migration, invasion and promoted apoptosis of non-small cell lung cancer cells by negative regulating HMGB
Expression of Concern: Over-expression of microRNA-758 inhibited proliferation, migration, invasion and promoted apoptosis of non-small cell lung cancer cells by negative regulating HMGB Open
View article: Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation
Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation Open
Mitochondrial dysfunction and lipid metabolic disturbance may promote pathologic α-synuclein (α-syn) aggregation, accelerating the progression of Parkinson's disease (PD). Whether extracellular matrices are associated with those pathologic…
View article: Integrated-omics analysis defines subtypes of hepatocellular carcinoma based on circadian rhythm
Integrated-omics analysis defines subtypes of hepatocellular carcinoma based on circadian rhythm Open
We classify the HCC patients into three distinct groups based on circadian rhythm and identify their specific biomarkers. Within these groups greater HCCcrds was associated with worse prognosis. This approach has the potential to improve p…
View article: Vascular depression: A comprehensive exploration of the definition, mechanisms, and clinical challenges
Vascular depression: A comprehensive exploration of the definition, mechanisms, and clinical challenges Open
Vascular depression (VaDep), which was proposed over two decades ago, is a distinct subtype of depression primarily observed in patients with stroke and cerebral small-vessel disease and is characterized by white matter hyperintensities; h…
View article: Identification of biomarkers of shrinkage modes after neoadjuvant therapy in HER-2 positive breast cancer
Identification of biomarkers of shrinkage modes after neoadjuvant therapy in HER-2 positive breast cancer Open
Purpose: A nomogram to predict shrinkage modes after neoadjuvant therapy (NAT) was constructed in HER-2 positive (HER2+) breast cancer. The value and mechanism of targeting long noncoding RNA (lncRNA) as efficacy prediction biomarker was a…
View article: Oral hygiene is independently associated with early stroke-associated pneumonia in hospitalized patients with ischemic stroke: An observational study
Oral hygiene is independently associated with early stroke-associated pneumonia in hospitalized patients with ischemic stroke: An observational study Open
Stroke-associated pneumonia (SAP) is a major stroke complication. Oral microorganisms are important contributors to SAP. Here, we aimed to investigate whether oral hygiene is associated with early SAP (<72 h of stroke onset) in patients wi…
View article: Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy
Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy Open
In this work, a series of bifunctional PD-L1/CD73 (cluster of differentiation 73) small-molecule inhibitors were designed and synthesized. Among them, CC-5 showed the strongest PD-L1 inhibitory effects with an IC50 of 6 n…
View article: Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy
Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy Open
In this work, a novel series of heterotricyclic DNA-PK inhibitors were rationally designed, synthesized, and assessed for their biological activity. In the DNA-PK biochemical assay, most compounds displayed potent enzymatic activity, with …
View article: Discovery of Novel <scp>d</scp>-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy
Discovery of Novel <span>d</span>-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy Open
In this work, we rationally designed, synthesized, and evaluated a series of novel d-(+)-biotin-conjugated PD-L1 inhibitors for targeted cancer therapy. Among them, SWS1 exhibited the highest anti-PD-1/PD-L1 activity with an IC…
View article: Apatinib successfully administered in malignant tumour patients with severe hypotension: a case series, literature review, and considerations for treatment
Apatinib successfully administered in malignant tumour patients with severe hypotension: a case series, literature review, and considerations for treatment Open
The most notable side-effect of apatinib, a novel antiangiogenic agent for the treatment of cancer, is hypertension, but there are few published studies regarding the use of apatinib to treat patients with cancer and severe hypotension. He…
View article: P76.77 Combination of EGFR-TKIs with Chemotherapy versus EGFR-TKIs alone in EGFR-Mutant Advanced NSCLC with Concomitant Genetic Alterations
P76.77 Combination of EGFR-TKIs with Chemotherapy versus EGFR-TKIs alone in EGFR-Mutant Advanced NSCLC with Concomitant Genetic Alterations Open
View article: Pretreatment Serum Ferritin as a Prognostic Indicator in Advanced Cancer Patients Treated With Apatinib: A Retrospective Cohort Study
Pretreatment Serum Ferritin as a Prognostic Indicator in Advanced Cancer Patients Treated With Apatinib: A Retrospective Cohort Study Open
Background: The present study has evaluated the prognostic value of pretherapy serum ferritin (SF) levels in advanced cancer patients receiving apatinib therapy after multiline treatment for drug resistance. Methods: This retrospective coh…
View article: Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB
Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB Open
Non-small cell lung cancer (NSCLC) is one of the most fatal types of cancer with significant mortality and morbidity worldwide. MicroRNAs (miRs) have been confirmed to have positive functions in NSCLC. In the present study, we try to explo…
View article: Chemotherapy with or without pemetrexed as second-line regimens for advanced non-small-cell lung cancer patients who have progressed after first-line EGFR TKIs: a systematic review and meta-analysis
Chemotherapy with or without pemetrexed as second-line regimens for advanced non-small-cell lung cancer patients who have progressed after first-line EGFR TKIs: a systematic review and meta-analysis Open
The second-line with-pemetrexed chemotherapeutic regimens provided significantly longer PFS and OS than non-pemetrexed chemotherapeutic regimens. These findings indicate that the with-pemetrexed chemotherapeutic regimen may be an optimal s…
View article: A phase I study of nedaplatin, pemetrexed and thoracic intensity-modulated radiotherapy for inoperable stage III lung adenocarcinoma
A phase I study of nedaplatin, pemetrexed and thoracic intensity-modulated radiotherapy for inoperable stage III lung adenocarcinoma Open
View article: Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway
Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway Open
Ruthenium (Ru) complexes are currently the focus of substantial interest because of their potential application as chemotherapeutic agents with broad anticancer activities. This study investigated the in vitro and in vivo anticancer activi…