Yousef Abu‐Amer
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View article: eLife Assessment: The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis
eLife Assessment: The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis Open
View article: NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx
NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx Open
Osteoclasts (OCs) differentiate from macrophages in response to RANKL. Here, we investigated the role of the NLRP3 inflammasome in mouse macrophages, with or without exposure to RANKL. Unexpectedly, we found that NLRP3 expression gradually…
View article: eLife Assessment: The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis
eLife Assessment: The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis Open
View article: eLife Assessment: Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
eLife Assessment: Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc Open
View article: eLife Assessment: Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
eLife Assessment: Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc Open
View article: Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments
Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments Open
View article: eLife Assessment: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation
eLife Assessment: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation Open
View article: eLife Assessment: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation
eLife Assessment: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation Open
View article: eLife Assessment: Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
eLife Assessment: Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc Open
View article: Super-Lubricous Polyethylene Glycol Hydrogel Microspheres for Use in Knee Osteoarthritis Treatments
Super-Lubricous Polyethylene Glycol Hydrogel Microspheres for Use in Knee Osteoarthritis Treatments Open
Knee osteoarthritis (OA) is characterized by cartilage degeneration and significant reduction in lubrication. One strategy to recover the natural lubrication of the synovial fluid is the injection of hydrogel microspheres, which offer both…
View article: eLife assessment: Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects
eLife assessment: Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects Open
View article: eLife assessment: Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein
eLife assessment: Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein Open
View article: eLife Assessment: Formation of Multinucleated Osteoclasts Depends on an Oxidized Species of Cell Surface Associated La Protein
eLife Assessment: Formation of Multinucleated Osteoclasts Depends on an Oxidized Species of Cell Surface Associated La Protein Open
The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cell…
View article: eLife Assessment: Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects
eLife Assessment: Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects Open
Treatments for congenital and acquired craniofacial (CF) bone abnormalities are limited and expensive. Current reconstructive methods include surgical correction of injuries, short-term bone stabilization, and long-term use of bone graftin…
View article: eLife Assessment: Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein
eLife Assessment: Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein Open
The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cell…
View article: eLife assessment: Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2
eLife assessment: Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2 Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract Osteoarthritis (OA) is a degen…
View article: eLife Assessment: Inhibition of miR-199b-5p reduces pathological alterations in Osteoarthritis by potentially targeting Fzd6 and Gcnt2
eLife Assessment: Inhibition of miR-199b-5p reduces pathological alterations in Osteoarthritis by potentially targeting Fzd6 and Gcnt2 Open
Osteoarthritis (OA) is a degenerative disease with a high prevalence in the elderly population, but our understanding of its mechanisms remains incomplete. Analysis of serum exosomal small RNA sequencing data from clinical patients and gen…
View article: Author response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Author response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
View article: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: Author Response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Author Response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: Author Response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Author Response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8
DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 Open
Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostas…
View article: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss
Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…
View article: eLife Assessment: Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects
eLife Assessment: Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects Open
Treatments for congenital and acquired craniofacial (CF) bone abnormalities are limited and expensive. Current reconstructive methods include surgical correction of injuries, short-term bone stabilization, and long-term use of bone graftin…
View article: DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation
DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation Open
Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenito…
View article: eLife assessment: Inhibition of miR-199b-5p reduces pathological alterations in Osteoarthritis by tar-geting Fzd6 and Gcnt2
eLife assessment: Inhibition of miR-199b-5p reduces pathological alterations in Osteoarthritis by tar-geting Fzd6 and Gcnt2 Open
Osteoarthritis (OA) is a degenerative disease with a high prevalence in the elderly population, but our understanding of its mechanisms remains incomplete. Analysis of serum exosomal small RNA sequencing data from clinical patients and gen…
View article: eLife Assessment: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation
eLife Assessment: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation Open
Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We've previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, th…