Yousin Suh
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View article: Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families
Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families Open
Life expectancy has steadily increased in the last two centuries, while healthspan has been lagging behind. Survival into extreme ages strongly clusters within families which often exhibit a delayed onset of (multi)morbidity, yet the under…
View article: Epigenetic CRISPR Screening of 9p21.3 Non-Coding Regions identifies Cis-Regulatory Elements of P16INK4a and P15INK4b Controlling Cellular Senescence
Epigenetic CRISPR Screening of 9p21.3 Non-Coding Regions identifies Cis-Regulatory Elements of P16INK4a and P15INK4b Controlling Cellular Senescence Open
Cellular senescence is a hallmark of aging and a promising target for extending human healthspan. Senescence is often accompanied by upregulation of the key senescence marker gene CDKN2A, yet the mechanism underlying its transcriptional ac…
View article: <i>LIPA</i>, a risk locus for coronary artery disease: decoding the variant-to-function relationship
<i>LIPA</i>, a risk locus for coronary artery disease: decoding the variant-to-function relationship Open
Background and Aims Translating human genomic discoveries into mechanistic insights requires linking genetic variations to candidate genes and their causal functional phenotypes. Genome-wide association studies have consistently identified…
View article: The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity
The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity Open
View article: Strategies for studying sex differences in brain aging
Strategies for studying sex differences in brain aging Open
View article: Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex
Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex Open
Summary Identifying senescent cells poses challenges due to their rarity, heterogeneity, and lack of a definitive marker. We performed Visium spatial transcriptomics (ST) and single nucleus RNA sequencing (snRNA-seq) on non-pathological hu…
View article: Biological sex matters in brain aging
Biological sex matters in brain aging Open
View article: Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses
Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses Open
View article: Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases
Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases Open
View article: Transcriptomic signatures of mouse ovarian aging and estropausal transition at single cell resolution
Transcriptomic signatures of mouse ovarian aging and estropausal transition at single cell resolution Open
Female reproductive aging affects fertility and overall health. Functional decline in mouse ovary during reproductive aging is accompanied by estrous cycle prolongation and cessation. However, the molecular mechanism underlying reproductiv…
View article: The Retrotransposon-Derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity
The Retrotransposon-Derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity Open
View article: An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells
An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells Open
Long interspersed element 1 (LINE-1; L1) are a family of transposons that occupy ~17% of the human genome. Though a small number of L1 copies remain capable of autonomous transposition, the overwhelming majority of copies are degenerate an…
View article: Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription
Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription Open
Because most DNA-binding transcription factors (dbTFs), including the architectural regulator CTCF, bind RNA and exhibit di-/multimerization, a central conundrum is whether these distinct properties are regulated post-transcriptionally to …
View article: In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood
In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood Open
Several decades of heterochronic parabiosis (HCPB) studies have demonstrated the restorative impact of young blood, and deleterious influence of aged blood, on physiological function and homeostasis across tissues, although few of the fact…
View article: A systems biology-based identification and in vivo functional screening of Alzheimer’s disease risk genes reveal modulators of memory function
A systems biology-based identification and in vivo functional screening of Alzheimer’s disease risk genes reveal modulators of memory function Open
View article: The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential
The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential Open
Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have be…
View article: REPRODUCTIVE AGING
REPRODUCTIVE AGING Open
Reproductive aging is a major health, personal and societal issue, but ovarian aging has received limited scientific attention. Ovarian aging has been known to influence diverse health outcomes in women including lifespan, cardiovascular d…
View article: OVARIAN AGING: A TARGET FOR GEROPROTECTION IN WOMEN
OVARIAN AGING: A TARGET FOR GEROPROTECTION IN WOMEN Open
The ovary is the first organ to undergo early-onset aging in the human body, affecting both fertility and overall health in women. However, the biological mechanisms underlying human ovarian aging have been poorly understood. To understand…
View article: Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architecture
Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architecture Open
The resolution limit of chromatin conformation capture methodologies (3Cs) has restrained their application in detection of fine-level chromatin structure mediated by cis-regulatory elements (CREs). Here, we report two 3C-derived methods, …
View article: Chromosome instability and aneuploidy in the mammalian brain
Chromosome instability and aneuploidy in the mammalian brain Open
View article: Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians
Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians Open
Genome‐wide association studies (GWAS) have pinpointed the chromosomal locus 9p21.3 as a genetic hotspot for various age‐related disorders. Common genetic variants in this locus are linked to multiple traits, including coronary artery dise…
View article: An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells
An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells Open
Long interspersed element 1 (L1) are a family of autonomous, actively mobile transposons that occupy ∼17% of the human genome. A number of pleiotropic effects induced by L1 (promoting genome instability, inflammation, or cellular senescenc…
View article: Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of <i> p16 <sup>INK4a</sup> </i>
Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of <i> p16 <sup>INK4a</sup> </i> Open
Glaucoma is a leading cause of irreversible blindness, with advanced age being the single most significant risk factor. However, the mechanisms underlying the relationship between aging and glaucoma remain unclear. Genome‐wide association …
View article: Targeted Sequencing of the 9p21.3 Region Reveals Association with Reduced Disease risks in Ashkenazi Jewish Centenarians
Targeted Sequencing of the 9p21.3 Region Reveals Association with Reduced Disease risks in Ashkenazi Jewish Centenarians Open
Genome-wide association studies (GWAS) have pinpointed the chromosomal locus 9p21.3 as a genetic hotspot for various age-related disorders. Common genetic variants in this locus are linked to multiple traits, including coronary artery dise…
View article: Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of<i>p16<sup>INK4a</sup></i>
Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of<i>p16<sup>INK4a</sup></i> Open
Glaucoma is a leading cause of irreversible blindness, with advanced age being the single most significant risk factor. However, the mechanisms underlying the relationship between aging and glaucoma remain unclear. Genome-wide association …
View article: The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity
The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity Open
MicroRNAs (miRNAs) have been demonstrated to modulate life span in the invertebrates C. elegans and Drosophila by targeting conserved pathways of aging, such as insulin/IGF-1 signaling (IIS). However, a role for miRNAs in modulating human …
View article: Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation
Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation Open
Given the pro and anti-geronic roles of the TGF-β superfamily in aging, we hypothesized that human longevity involves genetic variation in TGF-β signaling genes. Here we utilized a candidate functional genomic approach to identify and char…
View article: Evaluation of off-label rapamycin use to promote healthspan in 333 adults
Evaluation of off-label rapamycin use to promote healthspan in 333 adults Open
View article: Mitigating age-related somatic mutation burden
Mitigating age-related somatic mutation burden Open
View article: Initial development and testing of an exhaled microRNA detection strategy for lung cancer case–control discrimination
Initial development and testing of an exhaled microRNA detection strategy for lung cancer case–control discrimination Open
For detecting field carcinogenesis non-invasively, early technical development and case–control testing of exhaled breath condensate microRNAs was performed. In design, human lung tissue microRNA-seq discovery was reconciled with TCGA and …