Yousof Yakoub
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View article: Absence of phagolysosomal activation and high clearance efficiency define the low pulmonary toxicity of short asbestos fibers
Absence of phagolysosomal activation and high clearance efficiency define the low pulmonary toxicity of short asbestos fibers Open
View article: Transcriptomic profile of TiO2 particle overload in rat alveolar macrophages: examining responses between P25 and two pigment grade particles in vitro
Transcriptomic profile of TiO2 particle overload in rat alveolar macrophages: examining responses between P25 and two pigment grade particles in vitro Open
The industrial uses of titanium dioxide (TiO2) are extensive, with pigment grades (particle size > 100 nm) being the most common forms produced. Nanoforms (particle size < 100 nm) of TiO2 (e.g., P25) are also produced…
View article: Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO2 and carbon black
Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO2 and carbon black Open
View article: Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring
Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring Open
View article: Pulmonary and systemic effects of inhaled crystalline silica in the HOCl-induced mouse model of systemic sclerosis: An experimental model of Erasmus syndrome.
Pulmonary and systemic effects of inhaled crystalline silica in the HOCl-induced mouse model of systemic sclerosis: An experimental model of Erasmus syndrome. Open
View article: Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing
Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing Open
View article: Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
Effects of different amosite preparations on macrophages, lung damages, and autoimmunity Open
View article: Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages
Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages Open
While exposure to long amphibolic asbestos fibers (L > 10 µm) results in the development of severe diseases including inflammation, fibrosis, and mesothelioma, the pathogenic activity associated with short fibers (L < 5 µm) is less clear. …
View article: Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure Open
View article: Short vs. long amosite fibers: implication of particle clearance for asbestos-associated pulmonary inflammation and fibrosis
Short vs. long amosite fibers: implication of particle clearance for asbestos-associated pulmonary inflammation and fibrosis Open
<p>Exposure to asbestos is known for inducing inflammation, pulmonary fibrosis, lung cancer and malignant mesothelioma. Although several novel biomarkers and treatments are being tested, these chronic disorders are currently incurabl…
View article: Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure
Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure Open
We found that long-term oral exposure to dietary NPs at doses relevant for estimated human intakes disrupts the GM composition and function. These modifications did not appear associated with atheromatous or deleterious metabolic outcomes.
View article: Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes
Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes Open
Macrophages are not only derived from circulating blood monocytes or embryonic precursors but also expand by proliferation. The origin determines macrophage fate and functions in steady state and pathological conditions. Macrophages predom…
View article: Systemic effects and impact on the gut microbiota upon subacute oral exposure to silver acetate in rats
Systemic effects and impact on the gut microbiota upon subacute oral exposure to silver acetate in rats Open
View article: Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization Open
View article: Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles
Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles Open
Significance Silica particles with a population of nearly free silanols damage cellular membranes and initiate inflammatory reactions. Nearly free silanols are found on the surface of both fractured quartz and amorphous silica particles, a…
View article: LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals
LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals Open
View article: <i>In Vitro</i> and <i>In Vivo</i> Toxicity Studies on<i> Cymbopogon giganteus </i>Chiov. Leaves Essential Oil from Benin
<i>In Vitro</i> and <i>In Vivo</i> Toxicity Studies on<i> Cymbopogon giganteus </i>Chiov. Leaves Essential Oil from Benin Open
Cymbopogon giganteus Chiov. (Poaceae) is a medicinal plant used to treat various diseases in traditional medicine in several African countries. The present study aims to evaluate the oral and inhalation toxicity as well as the mutagenic ef…
View article: Respiratory hazard of Li-ion battery components: elective toxicity of lithium cobalt oxide (LiCoO2) particles in a mouse bioassay
Respiratory hazard of Li-ion battery components: elective toxicity of lithium cobalt oxide (LiCoO2) particles in a mouse bioassay Open
View article: New interplay between interstitial and alveolar macrophages explains pulmonary alveolar proteinosis (PAP) induced by indium tin oxide particles
New interplay between interstitial and alveolar macrophages explains pulmonary alveolar proteinosis (PAP) induced by indium tin oxide particles Open
View article: CCR2<sup>+</sup> monocytic myeloid‐derived suppressor cells (M‐MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor‐β1
CCR2<sup>+</sup> monocytic myeloid‐derived suppressor cells (M‐MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor‐β1 Open
Monocytes infiltrating scar tissue are predominantly viewed as progenitor cells. Here, we show that tissue CCR2 + monocytes have specific immunosuppressive and profibrotic functions. CCR2 + monocytic cells are acutely recruited to the lung…
View article: Additional file 1: Figure S1. of Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells
Additional file 1: Figure S1. of Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells Open
Mesotheliomas and leucocytes in peritoneal cavity of Wistar rats after mesotheliomagenic CNT-7 exposure. Figure S2. Peritoneal cell numbers after CNT and asbestos treatment in rats and mice. Figure S3. Proportions and in vitro activity of …
View article: Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells
Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells Open
View article: Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling
Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling Open
Carbon nanotubes (CNT) have been reported to induce lung inflammation and fibrosis in rodents. We investigated the direct and indirect cellular mechanisms mediating the fibrogenic activity of multi-wall (MW) CNT on fibroblasts. We showed t…