Explanipedia

Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols Open

Fatiha Ghilane, Nasreddine El Omari, Khang Wen Goh, Ilhame Bourais, Youssef Bakri , et al. · 2025

Cervico-Vaginal Microbiome Dynamics Across HPV-Driven Lesion Stages in Moroccan Women Open

Malika Allali, Khaoula Errafii‬, Rachid El Fermi, Karima Fichtali, Sanaa El Majjaoui , et al. · 2025

Cervical cancer (CC), often caused by persistent high-risk HPV infection, is a major health issue for Moroccan women. This study is the first in Morocco to examine how the cervico-vaginal microbiome differs across HPV-related clinical stag…

Advances in Molecular Diagnostics and Targeted Therapeutic Approaches in HER-2 Positive Breast Cancer Open

Basma Albanyahyati, Hicham El Hadi, Youssef Bakri, Mehdi Karkouri, Abdeladim Moumen · 2025

Human epidermal growth factor receptor 2 (HER2) is linked with aggressive tumors in breast carcinoma patients and results in poor outcomes. HER2 signaling in breast cancer also interacts with phosphoinositide-3-kinase (PI3K)/Akt signaling …

Exploring genetic and epigenetic alterations in hTERT gene in colorectal cancer Open

Meryem Jafari, Boutaina Addoum, Abdelilah Laraqui, Mohammed Oukabli, Ahmed Bounaim , et al. · 2025

Introduction: Colorectal cancer (CRC) is a heterogeneous and multifactorial malignancy driven by a series of genetic and epigenetic alterations. In this field, telomere/telomerase dysfunction contributes to CRC carcinogenesis by impairing …

The Gut Mycobiome for Precision Medicine Open

Islam El Jaddaoui, Sofia Sehli, Najib Al Idrissi, Youssef Bakri, Lahcen Belyamani , et al. · 2025

The human gastrointestinal tract harbors a vast array of microorganisms, which play essential roles in maintaining metabolic balance and immune function. While bacteria dominate the gut microbiome, fungi represent a much smaller, often ove…

Cervical cancer in Morocco: a literature review on risk factors, prevalence, and healthcare challenges Open

Malika Allali, Khaoula Errafii‬, Maryame Lamsisi, Karima Fichtali, Sanae El Majjaoui , et al. · 2025

Cervical cancer (CC) stands as the second most prevalent cancer among women in Morocco, with an estimated annual incidence of 2165 cases and over 1199 associated deaths. However, the lack of a comprehensive national registry requires cauti…

Seroprevalence and persistence of humoral immunity in response to SARS-CoV-2 vaccination and mild infection in Morocco: a cross-sectional study Open

Nouhaila Najimi, Chaimae Kadi, Zainab Gaouzi, Nadia Dakka, Rabii Ameziane El Hassani , et al. · 2025

hybrid immunity, involving prior infection and full vaccination, offers enhanced and longer-lasting protection. These results support the need for targeted vaccination strategies to optimize immunity and reduce the risk of adverse outcomes…

Risk factors for cervical cancer in Morocco: a case-control study Open

Malika Allali, Khaoula Errafii‬, Rachid El Fermi, Nouredin Messaoudi, Karima Fichtali , et al. · 2025

Morocco faces a significant burden of CC, with HPV being the primary cause. Lifestyle risk factors like low education, male sexual behavior, multiple pregnancies, and sexual intercourse also contribute.

Machine learning prediction of histological types of breast cancer: a case study in Morocco Open

Fatima Ezahra Mouas, Latifa Doudach, Achraf Benba, Youssef Bakri, Nasri Issad , et al. · 2025

Prospective Validation of a One-Step RT-qPCR-based Test for Quantifying HER2 Gene Expression in Breast Cancer Open

Basma Albanyahayti, Hicham El Hadi, Youssef Bakri, Abdelatif Benider, Mehdi Karkouri , et al. · 2024

Our study shows that one-step RT-qPCR-based quantitation is an accurate and reproducible test to record HER2 gene expression for a better treatment orientation focusing on maximal therapeutic and survival outcome.

HPV Genotypes in Africa: Comprehensive Analysis of Genetic Diversity and Evolutionary Dynamics Open

Ardina Malika, EL FERMI Rachid, ERRAFII Khaoula, WAJIH RHALEM Abdelaziz, Karima Fichtali , et al. · 2024

Human papillomavirus (HPV) is a widespread and diverse group of viruses that are responsible for various clinical conditions, including cervical cancer, one of the most common cancers among women worldwide. In Africa, the prevalence and di…

Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer Open

Fatima Ben Ali, Zineb Qmichou, Mohamed Oukabli, Nadia Dakka, Youssef Bakri , et al. · 2024

Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties and adapt to environmental conditions, suc…

Pre-pandemic antibodies screening against SARS-CoV-2 and virus detection among children diagnosed with eruptive fevers Open

Nouhaila Najimi, Latifa Tajount, Zakia Regragui, Chaimae Remz, Rokaya Aitlhaj-Mhand , et al. · 2024

Objectives This study aims to assess the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies against the spike (S) and nucleocapsid (NP) proteins, as well as neutralizing antibodies against the rec…

The Tumor Suppressor BRCA1/2, Cancer Susceptibility and Genome Instability in Gynecological and Mammary Cancers Open

Yassire Oubaddou, Fatima Ben Ali, Fatima Ezzahrae Oubaqui, Zineb Qmichou, Youssef Bakri , et al. · 2023

BRCA1 and BRCA2 germline alterations highly predispose women to breast and ovarian cancers. They are mostly found within the TNBC (Triple-Negative Breast Cancer) and the HGSOC (High-Grade Serous Ovarian Carcinoma) subsets, known by an aggr…

BRCA1 Promoter Hypermethylation in Malignant Breast Tumors and in the Histologically Normal Adjacent Tissues to the Tumors: Exploring Its Potential as a Biomarker and Its Clinical Significance in a Translational Approach Open

Yassire Oubaddou, Mohamed Oukabli, Salma Fenniche, Abderrahim Elktaibi, Mohamed Reda Elochi , et al. · 2023

The hypermethylation status of the promoter region of the breast cancer 1 (BRCA1), a well-known tumor suppressor gene, has been extensively investigated in the last two decades as a potential biomarker for breast cancer. In this retrospect…

A Comparative Analysis of NOX4 Protein Expression in Malignant and Non-Malignant Thyroid Tumors Open

Salma Fenniche, Mohamed Oukabli, Yassire Oubaddou, Hafsa Chahdi, Amal Damiri , et al. · 2023

The comparative analysis of the expression of the reactive oxygen species-generating NADPH oxidase NOX4 from TCGA data shows that the NOX4 transcript is upregulated in papillary thyroid carcinomas (PTC)-BRAFV600E tumors compared to PTC-BRA…

Insights into the T-cell response to SARS-CoV-2 Open

Chaimae Kadi, Nouhaila Najimi, M. Zakaria, Youssef Bakri, Seghrouchni Fouad · 2023

Following infection with SARS-CoV-2, cellular components of the adaptive immune system play a crucial role in eliminating the virus. Specifically, virus-specific CD4+ and CD8+ T cells generate effector cytokines and display cytotoxic activ…

Editorial expression of concern: Retama monosperma n-hexane extract induces cell cycle arrest and extrinsic pathway-dependent apoptosis in jurkat cells Open

Lamiae Belayachi, Clara Aceves-Luquero, Nawal Merghoub, Youssef Bakri, Silvia Fernández de Mattos , et al. · 2022

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials Open

Saad Bakrim, Nasreddine El Omari, Naoufal El Hachlafi, Youssef Bakri, Learn‐Han Lee , et al. · 2022

Given the stochastic complexity of cancer diseases, the development of chemotherapeutic drugs is almost limited by problems of selectivity and side effects. Furthermore, an increasing number of protective approaches have been recently cons…

Viral aetiology of influenza-like illnesses and severe acute respiratory illnesses in Morocco, September 2014 to December 2016 Open

Abderrahman Bimouhen, Zakia Regragui, Fatima El Falaki, Hassan Ihazmade, Samira Benkerroum , et al. · 2022

We found that RSV was predominant among SARI cases in Morocco, particularly in children under 5 years of age. Our results are in line with reported data from other parts of the world, stating that RSV is the leading cause of lower respirat…

Validation of the Moroccan version of the Cohen perceived stress scale (PSS-10) among women with Breast cancer Open

Chaimaa Mounjid, Hind Mrabti, Leila Alaoui Sossé, Abdelilah Laraqui, Véronique Chajès , et al. · 2022

BackgroundThe possible contribution of psychological stress to the development of BC has been largely investigated. One of the most extensively used psychological scales is the Perceived Stress Scale (Health Soc Behav 24:385 − 96, 1983), w…

Correlation genotype-phenotype: <i>MEFV</i> gene mutations and Moroccan patients with rheumatoid arthritis Open

Hakima Missoum, Najlae Adadi, Mohammed Alami, Hamza Toufik, Abdelhakim Bouyahya , et al. · 2022

the results of this study suggest that MEFV gene mutations appear to be an aggravating factor severity of RA and consequently, patients with RA might be screened for MEFV gene mutations in countries where FMF is frequent. We report also th…

IMPACT OF SOCIO-DEMOGRAPHIC CHARACTERISTICS ON THE SEVERITY OF RHEUMATOID ARTHRITIS IN MOROCCO Open

Hakima Missoum, Hamza Toufik, Mohammed Alami, Najlae Adadi, Fatima Bachir , et al. · 2021

The etiology of rheumatoid arthritis (RA) remains to date unknown.However, according to the main hypothesis, it has been proposed that several factors are contributing to its development.Among them, we find the socio-demographic factors.Th…

Anti-inflammatory and analgesic properties of Moroccan medicinal plants: Phytochemistry, in vitro and in vivo investigations, mechanism insights, clinical evidences and perspectives Open

Abdelhakim Bouyahya, Fatima‐Ezzahrae Guaouguaou, Nasreddine El Omari, Naoual El Menyiy, Abdelaali Balahbib , et al. · 2021

Gut-Lung Axis in COVID-19 Open

Imane Allali, Youssef Bakri, Saaïd Amzazi, Hassan Ghazal · 2021

COVID-19 is a pandemic infection of the respiratory system caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral ribonucleic acid (RNA) was found in many parts of the COVID-19 patients including the stool, sugge…

Molecular Insights of Immune Responses Variability in COVID-19 Patients: A Review Open

Omar Belmehdi, Maryam Hakkour, Mohamed Bakha, Jamal Abrini, Youssef Bakri , et al. · 2021

Currently, a novel coronavirus disease 2019 (COVID 19) caused by SARS-CoV-2 has emerged worldwide. This chronic viral infection causes an acute respiratory distress syndrome (ARDS) which its pathophysiology is not yet well elucidated. Howe…

Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients Open

Sofia Sehli, Imane Allali, Rajaa Chahboune, Youssef Bakri, Najib Al Idrissi , et al. · 2021

Over the last decade, it has become increasingly apparent that the microbiome is a central component in human well-being and illness. However, to establish innovative therapeutic methods, it is crucial to learn more about the microbiota. T…

BRAFV600E hot spot mutation in thyroid carcinomas: first Moroccan experience from a single-institution retrospective study Open

Meryem Kaabouch, Hafsa Chahdi, Naïma Azouzi, Mohammed Oukabli, Issam Rharrassi , et al. · 2020

Background: The incidence of thyroid cancer is increasing worldwide at an alarming rate. BRAFV600E mutation is described to be associated with a worse prognostic of thyroid carcinomas, as well as extrathyroidal invasion and increased morta…

Cancer Omics in Africa: Present and Prospects Open

Islam El Jaddaoui, Imane Allali, Sofia Sehli, Karim Ouldim, Salsabil Hamdi , et al. · 2020

During the last century, cancer biology has been arguably one of the most investigated research ﬁelds. To gain deeper insight into cancer mechanisms, scientists have been attempting to integrate multi omics data in cancer research. Cancer …

Lawsone quantification in Lawsonia inermis L. by HPLC-MS: How does the temperature and pluviometry affect lawsone concentration? Open

Fatima‐Zahra Alem, Samira Ananthabothla Gita, Lise Cougnaud, Cedric Affnar, Issmail Nounah , et al. · 2020

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