Youtao Lu
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View article: Microbiome-immune crosstalk in allergic rhinitis: lung and intestinal microbiota mechanisms
Microbiome-immune crosstalk in allergic rhinitis: lung and intestinal microbiota mechanisms Open
Allergic rhinitis (AR) is a prevalent immune-mediated upper respiratory disorder that manifests as an itchy nose, nasal congestion, a runny nose, and other symptoms. Emerging research suggests that AR, beyond its IgE-mediated hypersensitiv…
View article: Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons
Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons Open
View article: Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons
Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons Open
Background Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting ‘normal’ mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDNA …
View article: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential
CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential Open
View article: HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation Open
View article: Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity Open
Macrophages play a pivotal role in tumor immunity. We report that reprogramming of macrophages to tumor-associated macrophages (TAMs) promotes the secretion of exosomes. Mechanistically, increased exosome secretion is driven by MADD, which…
View article: Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures
Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures Open
View article: Single Cell Spatial Chromatin Analysis of Fixed Immunocytochemically Identified Neuronal Cells
Single Cell Spatial Chromatin Analysis of Fixed Immunocytochemically Identified Neuronal Cells Open
Assays examining the open-chromatin landscape in single cells require isolation of the nucleus, resulting in the loss of spatial/microenvironment information. Here we describe CHEX-seq ( CH romatin EX posed) for identifying single-stranded…
View article: Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response Open
View article: Correction: Corrigendum: Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation
Correction: Corrigendum: Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation Open
View article: Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation
Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation Open
Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current therapies attempt to control the immune response to limit degeneration, commonly promoting immunodepression. Differently, mechanical stimulation is…