You‐Yong Tian YOU? Author Swipe

Last 10y

Serum LDH and NLR as Diagnostic Biomarkers for Drooling in Parkinson's Disease Open

Xixi Wang, Jialiang Shi, Huihui Jin, Gao Qin, Qing Huang , et al. · 2025

Objective Drooling, a prevalent non-motor symptom in Parkinson’s disease (PD), lacks standardized diagnostic biomarkers. This study investigated the association between systemic inflammatory markers—serum neutrophil-to-lymphocyte ratio (NL…

A rapid multi-parametric quantitative MR imaging method to assess Parkinson’s disease: a feasibility study Open

Min Duan, Rongrong Pan, Qing Gao, Xinying Wu, Hai Lin , et al. · 2024

Background MULTIPLEX is a single-scan three-dimensional multi-parametric MRI technique that provides 1 mm isotropic T1-, T2*-, proton density- and susceptibility-weighted images and the corresponding quantitative maps. This study aimed to …

Motor symptoms of Parkinson's disease are affected by temperature: A controlled pilot study Open

Ting Huang, Xixi Wang, Chenyu Gao, Jinying Zhao, Rong‐Rong Pan , et al. · 2024

Purpose The motor symptoms (MS) of Parkinson's disease (PD) have been affecting the quality of life in patients. In clinical practice, most patients with PD report that MS are more severe in winter than in summer, and hyperthermic baths (H…

Drooling disrupts the brain functional connectivity network in Parkinson's disease Open

Ting Huang, Lili Tang, Jinying Zhao, Song‖an Shang, Yu‐Chen Chen , et al. · 2023

Aims This study aimed to investigate the causal interaction between significant sensorimotor network (SMN) regions and other brain regions in Parkinson's disease patients with drooling (droolers). Methods Twenty‐one droolers, 22 PD patient…

Dysregulation of Circulatory Levels of lncRNAs in Parkinson's disease Open

Ting Huang, Jin-Ying Zhao, Rong‐Rong Pan, Teng Jiang, Xinxin Fu , et al. · 2022

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder. The emerging evidence suggests that long non-coding RNAs (lncRNAs) are involved in the pathogenesis of PD. In this study, we used gene expression pr…

Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease Open

Song’an Shang, Jing Ye, Jingtao Wu, Hongying Zhang, Weiqiang Dou , et al. · 2022

Pathological process in Parkinson’s disease (PD) is accompanied with functional and metabolic alterations. The time-varying properties of functional coherence and their coupling to regional perfusion are still rarely elucidated. To investi…

Hybrid PET-MRI for early detection of dopaminergic dysfunction and microstructural degradation involved in Parkinson’s disease Open

Song’an Shang, Daixin Li, You‐Yong Tian, Rushuai Li, Hong-Dong Zhao , et al. · 2021

Dopamine depletion and microstructural degradation underlie the neurodegenerative processes in Parkinson’s disease (PD). To explore early alterations and underlying associations of dopamine and microstructure in PD patients utilizing the h…

Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease Open

You‐Yong Tian, Yingdong Zhang, Qing Gao, Rui Chen, Liang Wu , et al. · 2021

Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson's disease. Recent research indicates that angiotensin-(1-7) plays …

A Han Chinese Family With Early-Onset Parkinson's Disease Carrying Novel Frameshift Mutation and Compound Heterozygous Mutation of PRKN Appearing Incompatible With MDS Clinical Diagnostic Criteria Open

Chenyu Gao, Ting Huang, Rui Chen, Zhenhua Yuan, You‐Yong Tian , et al. · 2020

Around 15% of patients with Parkinson's disease (PD) have a family history, and 5-10% have confirmed genetic causes. PRKN is the most common gene responsible for early-onset Parkinson's disease (EOPD), while rare variants of PLA2…

View article: Han Chinese family with early‐onset Parkinson's disease carries novel compound heterozygous mutations in the <i>PARK2</i> gene

Han Chinese family with early‐onset Parkinson's disease carries novel compound heterozygous mutations in the <i>PARK2</i> gene Open

Ting Huang, Chenyu Gao, Liang Wu, Pengyu Gong, Ji‐Zheng Wang , et al. · 2019

Purpose To identify deletions, duplications, and point mutations in 55 previously reported genes associated with Parkinson's disease (PD) and certain genes associated with tremor, spinocerebellar ataxia, and dystonia in a Han Chinese pedig…

View article: PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease

PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease Open

Bian‐Rong Wang, Jian‐Quan Shi, Nian-Nian Ge, Zhou Ou, You‐Yong Tian , et al. · 2018

View article: Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson’s disease

Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson’s disease Open

Qing Gao, Zhou Ou, Teng Jiang, You‐Yong Tian, Junshan Zhou , et al. · 2017

Loss of dopaminergic neurons within the substantia nigra (SN) is a pathological hallmark of Parkinson's disease (PD), which leads to the onset of motor symptoms. Previously, our in vitro studies revealed that Angiotensin II (Ang II) induce…

View article: Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons

Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons Open

Zhou Ou, Teng Jiang, Qing Gao, You‐Yong Tian, Junshan Zhou , et al. · 2016

Introduction: We recently demonstrated that angiotensin II (Ang II) was involved in the etiology of Parkinson’s disease (PD) via induction of apoptosis of dopaminergic neurons, but the mechanisms are not completely elucidated. Here, we ask…