Betty Y.S. Kim
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View article: CTIM-40. IMMUNE PROFILING OF GBM TUMOR TISSUES COLLECTED LONGITUDINALLY FROM PATIENTS TREATED WITH AN ONCOLYTIC VIRUS
CTIM-40. IMMUNE PROFILING OF GBM TUMOR TISSUES COLLECTED LONGITUDINALLY FROM PATIENTS TREATED WITH AN ONCOLYTIC VIRUS Open
Glioblastoma (GBM) is a highly aggressive brain tumor associated with multiple cell subsets, including immune cells, which have been difficult to study longitudinally due to safety concerns about accessing the brain multiple times in a sin…
View article: IMMU-89. Association of SARS-COV-2 mRNA vaccines on PD-L1 expression and clinical tresponses to immune checkpoint blockade in patients with intracranial tumors
IMMU-89. Association of SARS-COV-2 mRNA vaccines on PD-L1 expression and clinical tresponses to immune checkpoint blockade in patients with intracranial tumors Open
We previously demonstrated that personalized mRNA vaccines enhance responses to immune checkpoint inhibitors (ICI) in part by stimulating production of Type I IFN. Since this surge in Type I IFN is independent of the antigens encoded by ea…
View article: MMAP-12 CONVENTIONAL SURGICAL RESECTION VERSUS STEREOTACTIC RADIOSURGERY FOR 1-3 CM SINGLE BRAIN METASTASES
MMAP-12 CONVENTIONAL SURGICAL RESECTION VERSUS STEREOTACTIC RADIOSURGERY FOR 1-3 CM SINGLE BRAIN METASTASES Open
There is a paucity of studies comparing conventional surgical resection (CSR) and stereotactic radiosurgery (SRS) for single brain metastases (BMs). This study evaluates local treatment failure (LTF) in patients with single, treatment-naïv…
View article: Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles
Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles Open
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes severe cartilage erosion in joints. Current treatments are limited in accessing a 3D platform that not only supports chondrocyte recovery and new cartilage matrix form…
View article: Targeting immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response
Targeting immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response Open
Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME) and dampen the immune response, negatively affecting patient survival. Therefore, targeting TAMs could address the limitations of current cancer treatment…
View article: In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy
In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy Open
Recent studies have highlighted the pivotal role of the cGAS‐STING pathway in cancer immunotherapy. However, clinical trials with cGAS‐STING pathway agonists have faced setbacks thanks to their short biological half‐life, lack of tumor spe…
View article: NIR-II Imaging Guided Accurate Identification of Paraspinal Muscle Degeneration Through Targeting the Lysosomal Membrane Protein Sidt2
NIR-II Imaging Guided Accurate Identification of Paraspinal Muscle Degeneration Through Targeting the Lysosomal Membrane Protein Sidt2 Open
This study presents a platform for ultra-early detection of degenerative paraspinal muscles using NIR-II imaging, providing a theoretical basis for early intervention based on the multifunctionality of nanoprobes. This is the first applica…
View article: Investigative needle core biopsies support multimodal deep-data generation in glioblastoma
Investigative needle core biopsies support multimodal deep-data generation in glioblastoma Open
Glioblastoma (GBM) is an aggressive primary brain cancer with few effective therapies. Stereotactic needle biopsies are routinely used for diagnosis; however, the feasibility and utility of investigative biopsies to monitor treatment respo…
View article: Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions
Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions Open
Current strategies for active targeting in the brain are entirely based on the effective interaction of the ligand with the orthosteric sites of specific receptors on the blood-brain barrier (BBB), which is highly susceptible to various pa…
View article: Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma
Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma Open
Despite the recent successes of immune checkpoint inhibitors (ICIs) in treating advanced melanoma, durable clinical responses still remain limited. To boost immune responses, agents that target immune regulators, such as the Stimulator of …
View article: EXTH-58. BLOCKING IMMUNE CHECKPOINT— LAIR1: DISRUPTING THE LAIR1—FXIII-A—COLLAGEN IMMUNOSUPPRESSIVE CIRCUIT FOR ENHANCED ANTITUMOR THERAPEUTICS
EXTH-58. BLOCKING IMMUNE CHECKPOINT— LAIR1: DISRUPTING THE LAIR1—FXIII-A—COLLAGEN IMMUNOSUPPRESSIVE CIRCUIT FOR ENHANCED ANTITUMOR THERAPEUTICS Open
BACKGROUND Recent evidence indicates that tumor-associated myeloid cells (TAMCs), including tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), play a crucial role in glioblastoma (GBM) immunosuppression and p…
View article: CNSC-60. SYNERGISTIC IMMUNOMODULATION THROUGH DUAL ANTIBODY THERAPY TARGETING CD47 AND CD24 FOR ENHANCED ANTITUMOR IMMUNITY IN GLIOBLASTOMA
CNSC-60. SYNERGISTIC IMMUNOMODULATION THROUGH DUAL ANTIBODY THERAPY TARGETING CD47 AND CD24 FOR ENHANCED ANTITUMOR IMMUNITY IN GLIOBLASTOMA Open
Tumor cell phagocytosis by antigen-presenting cells (APCs) plays a pivotal role in fostering antitumor immunity. However, glioblastoma, known for its evasive strategies, exploits key phagocytosis checkpoints, including CD47, CD24, and beta…
View article: TMIC-20. UNLOCKING THE POTENTIAL OF HYPOXIA REDUCTION IN RESHAPING THE GLIOBLASTOMA TUMOR MICROENVIRONMENT FOR ENHANCED THERAPEUTIC SYNERGY
TMIC-20. UNLOCKING THE POTENTIAL OF HYPOXIA REDUCTION IN RESHAPING THE GLIOBLASTOMA TUMOR MICROENVIRONMENT FOR ENHANCED THERAPEUTIC SYNERGY Open
Glioblastoma (GBM) tumors respond poorly to nearly all cancer therapies due to their highly immunosuppressive tumor microenvironment (TME). Hypoxia exacerbates this immunosuppression by upregulating the hypoxia-inducible factor (HIF) pathw…
View article: IMMU-50. IMPACT OF SARS-COV-2 MRNA VACCINES ON PD-L1 EXPRESSION IN INTRACRANIAL TUMORS
IMMU-50. IMPACT OF SARS-COV-2 MRNA VACCINES ON PD-L1 EXPRESSION IN INTRACRANIAL TUMORS Open
Although immune checkpoint inhibitor (ICI) effectiveness is correlated with intra-tumoral PD-L1 expression, there are no clinically available methods to improve sensitivity to ICIs by modulating PD-L1 expression. mRNA vaccines stimulate ro…
View article: Response of treatment-naive brain metastases to stereotactic radiosurgery
Response of treatment-naive brain metastases to stereotactic radiosurgery Open
With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic ra…
View article: Blocking Immune Checkpoint—LAIR1: Disrupting the LAIR1—FXIII-A—Collagen Immunosuppressive Circuit for Enhanced Antitumor Therapeutics
Blocking Immune Checkpoint—LAIR1: Disrupting the LAIR1—FXIII-A—Collagen Immunosuppressive Circuit for Enhanced Antitumor Therapeutics Open
Recent evidence suggests that tumor-associated myeloid cells (TAMCs), which include tumor-associated macrophages (TAM) and myeloid-derived suppressor cells (MDSC), play a significant role in cancer immunosuppression and progression. These …
View article: Fig. S17 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S17 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S16 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S16 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S1 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S1 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S12 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S12 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S14 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S14 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S22 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S22 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S13 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S13 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Fig. S15 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Fig. S15 from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
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View article: Data from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity
Data from Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity Open
Ionizing radiation is known to possess immune modulatory properties. However, how radiotherapy (RT) may complement with different types of immunotherapies to boost antitumor responses is unclear. In mice implanted with EO771 syngeneic tumo…