David Y. Chen
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View article: 382 Acute Myeloid Leukemia with Concurrent NPM1 and TP53 mutations: A Classification Dilemma
382 Acute Myeloid Leukemia with Concurrent NPM1 and TP53 mutations: A Classification Dilemma Open
Introduction/Objective The current ICC and WHO classifications emphasize the importance of genetic alterations in the diagnosis of acute myeloid leukemia (AML). Mutations in NPM1 and TP53 are considered disease-defining, with cases classif…
View article: A Coincidence of Purpose: The Prelude of the Chinese Materia Medica Research at the Peking Union Medical College in 1920
A Coincidence of Purpose: The Prelude of the Chinese Materia Medica Research at the Peking Union Medical College in 1920 Open
This paper reconstructs in detail the course leading to the inception of the Chinese material medica (CMM) research at the Peking Union Medical College (PUMC) in 1920. By analyzing the primary materials from several archives, it provides, …
View article: A systematic review and meta-analysis of the utility of quantitative, imaging-based approaches to predict radiation-induced toxicity in lung cancer patients
A systematic review and meta-analysis of the utility of quantitative, imaging-based approaches to predict radiation-induced toxicity in lung cancer patients Open
The majority of existing literature using radiomics, dosiomics and machine learning has focused on radiation pneumonitis prediction. Future research should focus on toxicity prediction of other organs at risk and the adoption of these mode…
View article: Introduction to the 102st Volume of the UTMJ Issue on Technology in Medicine
Introduction to the 102st Volume of the UTMJ Issue on Technology in Medicine Open
Volume 102 of the UTMJ arrives at a transformative moment in medicine, where rapid technological innovations are reshaping clinical practice, ethics, and healthcare delivery. As advancements in artificial intelligence, digital therapeutics…
View article: Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate
Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate Open
Classical tissue recombination experiments demonstrate that cell-fate determination along the anterior–posterior axis of the Müllerian duct occurs prior to postnatal day 7 in mice. However, little is known about how these cell types are ma…
View article: Comparing NIH funding for skin disease research with US skin disease burden according to Global Burden of Disease 2021: a cross-sectional analysis identifies underfunded and overfunded diseases (Preprint)
Comparing NIH funding for skin disease research with US skin disease burden according to Global Burden of Disease 2021: a cross-sectional analysis identifies underfunded and overfunded diseases (Preprint) Open
BACKGROUND Understanding the burden of various skin diseases can help guide funding allocation for skin disease research. In 2015, Hagstrom and colleagues conducted a cross-sectional study that found partial correlation between United Sta…
View article: SURG-27. DIRECTIONALLY NON-ROTATING ELECTRIC FIELD THERAPY (DNEFT) DELIVERED THROUGH IMPLANTED ELECTRODES: A NOVEL SURGICAL PLATFORM FOR GLIOBLASTOMA IMMUNOTHERAPY
SURG-27. DIRECTIONALLY NON-ROTATING ELECTRIC FIELD THERAPY (DNEFT) DELIVERED THROUGH IMPLANTED ELECTRODES: A NOVEL SURGICAL PLATFORM FOR GLIOBLASTOMA IMMUNOTHERAPY Open
BACKGROUND While directionally rotating Tumor Treating Fields (TTF) therapy has garnered considerable clinical interest in recent years, there has been comparatively less focus on directionally non-rotating electric field therapy (dnEFT). …
View article: Functional profiling of murine glioma models highlights targetable immune evasion phenotypes
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes Open
Cancer intrinsic immune evasion mechanisms and pleiotropy represent a barrier to effective translation of cancer immunotherapy. This is acutely apparent for certain highly fatal cancers such as high-grade gliomas and glioblastomas. In this…
View article: Spatial Profiling of Ovarian Clear Cell Carcinoma Reveals Immune-Hot Features
Spatial Profiling of Ovarian Clear Cell Carcinoma Reveals Immune-Hot Features Open
Ovarian clear cell carcinoma (OCCC) has a high incidence in Asia, with a frequent occurrence at an early stage, but without sufficient data on molecular stratification for high-risk patients. Recently, immune-hot features have been propose…
View article: Protocol for a non-surgical model of perineural invasion for assessing neural drivers of cancer aggressiveness in mice
Protocol for a non-surgical model of perineural invasion for assessing neural drivers of cancer aggressiveness in mice Open
Perineural invasion (PNI) is a significant risk factor for cancer recurrence and metastasis; however, its mechanisms relating to cancer aggressiveness remain poorly understood. Here, we present a protocol for a non-surgical model of PNI in…
View article: Where Are We Now with Oncolytic Viruses in Melanoma and Nonmelanoma Skin Malignancies?
Where Are We Now with Oncolytic Viruses in Melanoma and Nonmelanoma Skin Malignancies? Open
Skin cancer prognosis has greatly improved recently due to the introduction of immune checkpoint inhibitors (ICIs). However, many patients with advanced skin cancer still experience immunotherapy resistance and disease progression during I…
View article: Mapping single-cell developmental potential in health and disease with interpretable deep learning
Mapping single-cell developmental potential in health and disease with interpretable deep learning Open
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cell fate in developmental systems. However, identifying the molecular hallmarks of potency – the capacity of a cell to differentiate into other cell types – has r…