Yuchen Liu
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View article: Overlapping community discovery based on graph embedding and label propagation algorithm
Overlapping community discovery based on graph embedding and label propagation algorithm Open
Traditional label propagation algorithms (LPA) exhibit instability and poor accuracy in community discovery, primarily due to random node selection, uncertain label update sequences, and neglect of node importance variations. We present GE…
View article: Strategic engineering of DNA aptamers as precision modulators in CRISPR-driven oncogene control
Strategic engineering of DNA aptamers as precision modulators in CRISPR-driven oncogene control Open
Objective: The goal of this study was to address the limited availability of intracellular protein-binding aptamers that restrict the potential of CRISPR-based signal conductor systems. We aimed to develop a programmable CRISPR-SaCas9 plat…
View article: Neutrophil gene expression in COVID-19 patients with acute respiratory distress syndrome
Neutrophil gene expression in COVID-19 patients with acute respiratory distress syndrome Open
Background Although an increase in neutrophil count has been observed in patients with coronavirus disease 2019 (COVID-19), the relationship between the systemic neutrophil transcriptome and clinical course of COVID-19 remains unclear. Hen…
View article: Mapping NK cell diversity in response to COVID-19 and mRNA vaccination
Mapping NK cell diversity in response to COVID-19 and mRNA vaccination Open
Human NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood. Here, we report that NK cell diversity emerges during peripheral development, infl…
View article: Engineered thoracic spinal cord organoids for transplantation after spinal cord injury
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury Open
Stem-cell-based neural tissue engineering and spinal cord organoids show promises for spinal cord injury repair. However, the native spinal cord presents cell heterogeneity and a stereotypical spatial structure that makes difficult their r…
View article: Privacy-Preserving and Communication-Efficient Federated Learning for Cloud-Scale Distributed Intelligence
Privacy-Preserving and Communication-Efficient Federated Learning for Cloud-Scale Distributed Intelligence Open
This study focuses on privacy protection and multi-party collaborative optimization in cloud computing environments. A federated learning framework is proposed, integrating differential privacy mechanisms and communication compression stra…
View article: Privacy-Preserving and Communication-Efficient Federated Learning for Cloud-Scale Distributed Intelligence
Privacy-Preserving and Communication-Efficient Federated Learning for Cloud-Scale Distributed Intelligence Open
This study focuses on privacy protection and multi-party collaborative optimization in cloud computing environments. A federated learning framework is proposed, integrating differential privacy mechanisms and communication compression stra…
View article: Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling
Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling Open
Human pluripotent stem cell (hPSC)-derived alveolar organoids have emerged as valuable tools for studying lung development, modeling pulmonary diseases, and drug discovery, though their application has been hindered by laborious differenti…
View article: SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks
SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks Open
Single‐cell cis‐regulatory relationships (CRRs) are essential for deciphering transcriptional regulation and understanding the pathogenic mechanisms of disease‐associated non‐coding variants. Existing computational methods struggle to accu…
View article: The integration strategy of Didang decoction against cerebral ischemia-reperfusion injury: Regulation of apoptosis-autophagy-inflammation network and validation of PI3K/Akt pathway
The integration strategy of Didang decoction against cerebral ischemia-reperfusion injury: Regulation of apoptosis-autophagy-inflammation network and validation of PI3K/Akt pathway Open
For the first time, this study systematically revealed the molecular mechanism by which Didang Decoction synergistically modulates metabolic networks and alleviates cerebral ischemia-reperfusion injury via multiple components.
View article: Fetal Sylvian Fissure Charts to Evaluate the Development of Fetal Brain using Prenatal MRI
Fetal Sylvian Fissure Charts to Evaluate the Development of Fetal Brain using Prenatal MRI Open
Objective: To explore the normal developmental pattern of the sylvian fissure (SF) in fetuses by MRI for better identifying cortical abnormalities in the early stage by quantifying the morphological characteristics. Methods: This study ret…
View article: A Review of Sipuleucel-T in Combination with Other Therapies for Metastatic Castration-Resistant Prostate Cancer
A Review of Sipuleucel-T in Combination with Other Therapies for Metastatic Castration-Resistant Prostate Cancer Open
Recent research has expanded the therapeutic landscape for sipuleucel-T by introducing several combination treatments. These include innovative hormone therapies (enzalutamide and abiraterone), immunomodulatory agents (including IL-15, IL-…
View article: Analysis of selectional preference for grassland ecological compensation methods under the perspective of herders differentiation
Analysis of selectional preference for grassland ecological compensation methods under the perspective of herders differentiation Open
Introduction Exploring herders’ preferences for grassland ecological compensation methods provides a decision-making basis for strengthening the incentive effects of grassland ecological compensation policies. Methods The research utilized…
View article: Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism
Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism Open
In summary, our study highlights that carrier-free SIL-SOR-MPs demonstrate the ability to reverse the progression of MASLD and present a promising therapeutic strategy.
View article: Exploring genes associated with metabolic dysfunction as therapeutic targets for head and neck cancers: a novel strategy
Exploring genes associated with metabolic dysfunction as therapeutic targets for head and neck cancers: a novel strategy Open
Evidence suggests a potential link between metabolic dysfunction and head and neck cancer (HNC). This study investigates the potential causal relationships between metabolic dysfunction and HNC using genetic data. While no significant caus…
View article: Innovative logic “AND” gate gene circuits for bladder cancer treatment: preclinical study
Innovative logic “AND” gate gene circuits for bladder cancer treatment: preclinical study Open
In the evolving field of precision oncology, the synthesis of gene circuits that specifically target cancer cells while preserving normal tissue marks a significant breakthrough. However, traditional approaches typically concentrate on sin…
View article: Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer
Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer Open
FOLFOX (5-Fluorouracil, Calcium Folinate combined with Oxaliplatin) is a preferred chemotherapy regimen for colon cancer, but its limited efficacy remains a major challenge, significantly impairs patient outcomes. There is an urgent need t…
View article: Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer
Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer Open
SAPCD2 serves as both a prognostic marker and a potential therapeutic target in PAAD, where its low expression may enhance responsiveness to specific drugs. These findings underscore SAPCD2's dual role in cancer progression and therapy.
View article: Minimalist infrared computational imaging with double-sided diffractive single-lens system
Minimalist infrared computational imaging with double-sided diffractive single-lens system Open
The hybrid-order monolithic imaging diffractive (HMID) lens was designed to address the issue of negative dispersion of diffractive optical elements (DOEs) in infrared minimalist optical systems. However, the imaging quality is negatively …
View article: A surgical orthotopic xenograft approach with immune response for colorectal cancer research
A surgical orthotopic xenograft approach with immune response for colorectal cancer research Open
The high morbidity and mortality of colorectal cancer (CRC) is a major challenge in clinical practice. Although a series of alternative research models of CRC have been developed, appropriate orthotopic animal models that reproduce the spe…
View article: Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders
Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders Open
Hemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow…
View article: RAC1-Amplified and RAC1-A159V Hotspot-Mutated Head and Neck Cancer Sensitive to the Rac Inhibitor EHop-016 In Vivo: A Proof-of-Concept Study
RAC1-Amplified and RAC1-A159V Hotspot-Mutated Head and Neck Cancer Sensitive to the Rac Inhibitor EHop-016 In Vivo: A Proof-of-Concept Study Open
Objective: RAC1 aberrations in head and neck squamous cell carcinoma (HNSCC) remain clinically inactionable today. Methods: Here, we investigated the clinical significance and potential druggability of RAC1 genomic aberrations in HNSCC. Re…
View article: Face-Human-Bench: A Comprehensive Benchmark of Face and Human Understanding for Multi-modal Assistants
Face-Human-Bench: A Comprehensive Benchmark of Face and Human Understanding for Multi-modal Assistants Open
Faces and humans are crucial elements in social interaction and are widely included in everyday photos and videos. Therefore, a deep understanding of faces and humans will enable multi-modal assistants to achieve improved response quality …
View article: Retraction: Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells
Retraction: Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells Open
Retraction of ‘Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells’ by Yincong Chen et al. , Mol. BioSyst. , 2017, 13 , 1597–1607, https://doi.org/10.1039/C7MB00202E.