Yu Chen
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View article: Molecular pathways underlying amyloid precursor protein–mediated regulation of adult-born neurons
Molecular pathways underlying amyloid precursor protein–mediated regulation of adult-born neurons Open
Cleavage of amyloid precursor protein (APP) produces toxic amyloid-beta peptides, which play a critical role in the pathogenesis of Alzheimer’s disease. Neuronal loss is a key feature of Alzheimer’s disease. Despite the importance of APP i…
View article: Prospects for geoneutrino detection with JUNO
Prospects for geoneutrino detection with JUNO Open
Geoneutrinos, which are antineutrinos emitted during the decay of long-lived radioactive elements inside Earth, serve as a unique tool for studying the composition and heat budget of our planet. The Jiangmen Underground Neutrino Observator…
View article: Survival nomogram for melanoma with bone metastasis based on the SEER database and an external validation cohort
Survival nomogram for melanoma with bone metastasis based on the SEER database and an external validation cohort Open
Background We aimed to develop and validate a comprehensive prognostic model for melanoma bone metastasis. Methods Data on melanoma bone metastasis patients were obtained from the SEER database and Fujian Cancer Hospital. Cox regression an…
View article: Electrocatalytic lignin depolymerization enabled by a biomass-supported atomically dispersed iron catalyst
Electrocatalytic lignin depolymerization enabled by a biomass-supported atomically dispersed iron catalyst Open
Transitioning from crude oil to renewable carbon sources is crucial for a circular economy. Lignin, a byproduct of the paper industry, has significant potential as a renewable feedstock, but its efficient depolymerization remains challengi…
View article: Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal‐Amplifying Fluidic Biomimetic Hydrogel
Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal‐Amplifying Fluidic Biomimetic Hydrogel Open
Cranial stem cell niches (SCNs) are intrinsically scarce and hypoactive, and, exacerbated by chronic inflammation in diabetes, lead to niche failure and regenerative deficit after injury. Herein, an in situ moldable fluidic biomimetic nich…
View article: Pathological responses to neoadjuvant immunochemotherapy: implications for survival and recurrence in patients with locally advanced esophageal squamous cell carcinoma
Pathological responses to neoadjuvant immunochemotherapy: implications for survival and recurrence in patients with locally advanced esophageal squamous cell carcinoma Open
PTs response may constitute a more prominent determinant of both OS and PFS than LNs status, and combining these factors enhances prognostic prediction.
View article: Ultra-broadband mirrors for ultrafast and ultra-intense laser sciences
Ultra-broadband mirrors for ultrafast and ultra-intense laser sciences Open
View article: Correction: Cardiac Overexpression of Chil1 Improves Wound Healing to Prevent Cardiac Rupture After Myocardial Infarction
Correction: Cardiac Overexpression of Chil1 Improves Wound Healing to Prevent Cardiac Rupture After Myocardial Infarction Open
View article: Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics
Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics Open
Advanced metal‐based nanomaterials (MBNs) represent a dynamic frontier in nanomedicine, offering a versatile platform for next‐generation diagnostics and therapeutics. Their tunable structures and catalytic, optical, and magnetic propertie…
View article: Triggering self‐supplied nanocatalytic reaction on Ti <sub>3</sub> C <sub>2</sub> MXene@CaO <sub>2</sub> ‐TiO <sub>2‐x</sub> for synergistic oral cancer therapy, antibacterial infection, and bone regeneration
Triggering self‐supplied nanocatalytic reaction on Ti <sub>3</sub> C <sub>2</sub> MXene@CaO <sub>2</sub> ‐TiO <sub>2‐x</sub> for synergistic oral cancer therapy, antibacterial infection, and bone regeneration Open
After oral carcinoma resection, postoperative cancer recurrence, bacterial infection, and craniomaxillofacial bone defect threaten patients’ health. Current treatment is mainly to repair bone defects by bone substitute implantation, but th…
View article: A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap
A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap Open
View article: Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment
Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment Open
Dendritic cell (DC)-based vaccines for solid tumors face major challenges, including limited tumor-specific antigens and immunosuppressive stroma. Here, we present a therapeutic nanovaccine (UCNP@MOF@MI@FM [UMMF]) composed of a DC/tumor fu…
View article: Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury
Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a severe neurological disorder requiring novel therapeutic strategies. We developed ultrasmall catalytic Ce 0.7 Zr 0.3 O 2 nanozymes (CZs) and investigated their neuroprotective potential in combination with…
View article: Does brain radiotherapy and lactate dehydrogenase (LDH) levels affect the prognosis of melanoma with brain metastases?
Does brain radiotherapy and lactate dehydrogenase (LDH) levels affect the prognosis of melanoma with brain metastases? Open
Objective: The prognosis of patients with advanced melanoma is poor, especially for those with brain metastases. Currently, there is no standard treatment regimen for patients with brain metastases in the later lines of therapy. The purpos…
View article: Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosa
Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosa Open
Retinal degeneration is a leading cause of blindness and a significant health burden during aging worldwide. Because of its complex pathogenic mechanisms, however, effective interventions applicable to multiple retinal degenerations remain…
View article: Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery Open
As an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities. It offers unparalleled control ov…
View article: Estimation of Subtropical Forest Aboveground Biomass Using Active and Passive Sentinel Data with Canopy Height
Estimation of Subtropical Forest Aboveground Biomass Using Active and Passive Sentinel Data with Canopy Height Open
Forest biomass is closely related to carbon sequestration capacity and can reflect the level of forest management. This study utilizes four machine learning algorithms, namely Multivariate Stepwise Regression (MSR), K-Nearest Neighbors (k-…
View article: Gut microbiome and serum metabolome alterations in osteosarcoma patients
Gut microbiome and serum metabolome alterations in osteosarcoma patients Open
Background Gut microbiota has been shown to initiate tumorigenesis and cancer metastasis in multiple cancer types. However, the functional alterations of gut microbiota and their association with metabolism in osteosarcoma patients remain …
View article: Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head
Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head Open
Exosomes derived from adipogenic BMSCs containing SPRY4 can induce SONFH-like injury by targeting PTPRB to suppress the TIE2/PI3K/AKT pathway, proposing targeted disruption of adipose-endothelial crosstalk as a novel therapeutic strategy f…
View article: Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy
Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy Open
View article: Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression
Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression Open
Macrophage pyroptosis has been identified as a critical pathological mechanism in inflammation-related atherosclerosis (AS). In this work, we have demonstrated that Zn 2+ features the strongest anti-inflammatory performance by screening 10…
View article: Biosponge‐Armored Nanodots Restore Redox‐Calcium Homeostasis to Mitigate Reperfusion‐Induced Injury in Ischemic Stroke
Biosponge‐Armored Nanodots Restore Redox‐Calcium Homeostasis to Mitigate Reperfusion‐Induced Injury in Ischemic Stroke Open
Antioxidant nanomaterials demonstrate significant neuroprotective potential in mitigating reperfusion injury associated with ischemic stroke. However, emerging nanocatalytic strategies targeting oxidative stress suffer from limited therape…
View article: Single-cell RNA sequencing uncovers intestinal immune alterations and cellular diversity from chronic fluoride exposure in mice
Single-cell RNA sequencing uncovers intestinal immune alterations and cellular diversity from chronic fluoride exposure in mice Open
Rationale: Chronic exposure to high-fluoride drinking water impairs intestinal structure and function, potentially damaging extraluminal tissues via the gut-organ axis. However, how lifelong exposure to naturally occurring moderate-…
View article: Defect-engineered sonopiezoelectric nanosheets enable sacrificial-agent-free hydrogen peroxide self-cycling for enhanced pancatalytic therapy
Defect-engineered sonopiezoelectric nanosheets enable sacrificial-agent-free hydrogen peroxide self-cycling for enhanced pancatalytic therapy Open
View article: Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low‐Temperature Photothermal Effects
Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low‐Temperature Photothermal Effects Open
Melanoma is characterized by rapid growth and high invasiveness, resulting in an exceptionally high malignancy and a significant propensity for metastasis. Current therapeutic modalities, such as chemotherapy and radiotherapy, exhibit limi…
View article: Novel Fluorescent Probe for Selective Recognition of G‐Quadruplex Based on Aggregation Induced Emission
Novel Fluorescent Probe for Selective Recognition of G‐Quadruplex Based on Aggregation Induced Emission Open
G‐quadruplex (G4) is four‐stranded noncanonical secondary DNA structures, which have been identified as potential targets for therapeutic intervention. It is crucial to detect G4 and search for ligands that target G4 with high selectivity …
View article: Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy
Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy Open
In-situ activation of cuproptosis shows considerable promise in cancer therapy. However, its efficacy is often hindered by the accumulation of copper ions and limitations of the activation strategy. Herein, a novel copper-palladium nitride…
View article: SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome Open
Introduction Polycystic ovary syndrome (PCOS) is characterized by follicular dysplasia, with granulosa cells (GCs) glycolysis playing a pivotal role in this pathology. Although the involvement of long noncoding RNAs (lncRNAs) in diverse bi…
View article: Broad-spectrum antioxidant and neuroprotective Prussian blue nanocatalyst for therapeutic intervention in autism spectrum disorder
Broad-spectrum antioxidant and neuroprotective Prussian blue nanocatalyst for therapeutic intervention in autism spectrum disorder Open
View article: Lanthanide-specific doping in vacancy-engineered piezocatalysts induces lysosomal destruction and tumor cell pyroptosis
Lanthanide-specific doping in vacancy-engineered piezocatalysts induces lysosomal destruction and tumor cell pyroptosis Open
In vitro and in vivo antineoplastic results confirm the desirable therapeutic effect on combating tumor. Especially, the iron and bismuth elemental components endow the nanocomposites with dual-mode computed tomography/magnetic resonance i…