Chunyu Cai
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View article: Spontaneous bladder rupture induced pseudo-acute kidney injury: A case report and literature review
Spontaneous bladder rupture induced pseudo-acute kidney injury: A case report and literature review Open
Rationale: Spontaneous rupture of the urinary bladder (SRUB) is a rare, easily missed cause of urinary ascites that mimics intrinsic renal failure through peritoneal reabsorption of urinary solutes (“reverse peritoneal dialysis”). Rapid re…
View article: A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases
A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases Open
Neuromuscular diseases such as amyotrophic lateral sclerosis and sarcopenia cause muscle atrophy, which preferentially affects fast-twitch glycolytic myofibers. The mechanisms underlying the susceptibility of fast myofibers to disease rema…
View article: Analysis of risk factors and prediction model construction for poor healing of perineal wounds after vaginal delivery: A retrospective case-control study
Analysis of risk factors and prediction model construction for poor healing of perineal wounds after vaginal delivery: A retrospective case-control study Open
The risk prediction model for poor perineal wound healing after vaginal delivery can reasonably predict the risk of poor incision healing, providing a basis for obstetric medical staff to take preventive management measures for high-risk g…
View article: ANGI-01. EXTRANEURAL METASTATIC EPENDYMOMA: DISTANT METASTASIS TO THE PLEURA, LUNGS, LYMPH NODES, AND BONE
ANGI-01. EXTRANEURAL METASTATIC EPENDYMOMA: DISTANT METASTASIS TO THE PLEURA, LUNGS, LYMPH NODES, AND BONE Open
Ependymomas are neuroepithelial tumors arising from ependymal cells surrounding the cerebral ventricles that account for 1.6-1.8% of primary CNS tumors. They rarely metastasize to extraneural structures, with one study reporting an inciden…
View article: A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution Open
Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscl…
View article: Rhabdomyolysis and Exercise Intolerance in a 45-Year-Old Man
Rhabdomyolysis and Exercise Intolerance in a 45-Year-Old Man Open
A 45-year-old man presented to neuromuscular clinic after a first-time episode of non-traumatic rhabdomyolysis after aerobic exercise.Prior to his diagnosis, he had an extensive medical workup to evaluate for elevated transaminases and cre…
View article: <scp>Myxovirus resistance protein A (MxA)</scp> expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis
<span>Myxovirus resistance protein A (MxA)</span> expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis Open
Introduction/Aims Myxovirus resistance protein A (MxA) is a type I interferon (IFN1) pathway activation marker and MxA sarcoplasmic expression is currently recognized as a highly specific marker for dermatomyositis (DM). However, we have f…
View article: TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb
TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb Open
In recent years, olfactory dysfunction has attracted increasingly more attention as a hallmark symptom of neurodegenerative diseases (ND). Deeply understanding the molecular basis underlying the development of the olfactory bulb (OB) will …
View article: Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy
Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy Open
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of …
View article: What’s new in neuromuscular pathology 2022: myopathy updates and gene therapies
What’s new in neuromuscular pathology 2022: myopathy updates and gene therapies Open
This compilation of new changes in the diagnosis and treatment of muscle and nerve disease is extracted from the latest publications from the European Neuromuscular Centre International workshops, FDA.gov and clinicaltrials.gov.
View article: A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle Open
A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process. We report the existence of a maturation checkpoint during muscle regeneration t…
View article: Biallelic variants in TAMM41 are associated with low muscle cardiolipin levels, leading to neonatal mitochondrial disease
Biallelic variants in TAMM41 are associated with low muscle cardiolipin levels, leading to neonatal mitochondrial disease Open
Mitochondrial disorders are clinically and genetically heterogeneous, with variants in mitochondrial or nuclear genes leading to varied clinical phenotypes. TAMM41 encodes a mitochondrial protein with cytidine diphosphate-diacylglycerol sy…
View article: Additional file 2 of Epigenetic and genomic profiling of chordoid meningioma: implications for clinical management
Additional file 2 of Epigenetic and genomic profiling of chordoid meningioma: implications for clinical management Open
Additional file 2: Raw annotated variants detected in chordoid meningiomas.
View article: Additional file 1 of Epigenetic and genomic profiling of chordoid meningioma: implications for clinical management
Additional file 1 of Epigenetic and genomic profiling of chordoid meningioma: implications for clinical management Open
Additional file 1: Detailed clinical and histopathological information on each chordoid meningioma case.
View article: Preoperative imaging of glioblastoma patients using hyperpolarized 13C pyruvate: Potential role in clinical decision making
Preoperative imaging of glioblastoma patients using hyperpolarized 13C pyruvate: Potential role in clinical decision making Open
Background Glioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells.13C MR spectroscopic imaging with hyperpolar…
View article: Biallelic loss of function variants in <scp><i>SYT2</i></scp> cause a treatable congenital onset presynaptic myasthenic syndrome
Biallelic loss of function variants in <span><i>SYT2</i></span> cause a treatable congenital onset presynaptic myasthenic syndrome Open
Synaptotagmins are integral synaptic vesicle membrane proteins that function as calcium sensors and regulate neurotransmitter release at the presynaptic nerve terminal. Synaptotagmin‐2 ( SYT2 ), is the major isoform expressed at the neurom…
View article: Multi-Site Optical Monitoring of Spinal Cord Ischemia during Spine Distraction
Multi-Site Optical Monitoring of Spinal Cord Ischemia during Spine Distraction Open
Optimal surgical management of spine trauma will restore blood flow to the ischemic spinal cord. However, spine stabilization may also further exacerbate injury by inducing ischemia. Current electrophysiological technology is not capable o…
View article: Distinct Expression Patterns of Carbonic Anhydrase IX in Clear Cell, Microcystic, and Angiomatous Meningiomas
Distinct Expression Patterns of Carbonic Anhydrase IX in Clear Cell, Microcystic, and Angiomatous Meningiomas Open
Clear cell, microcytic, and angiomatous meningiomas are 3 vasculature-rich variants with overlapping morphological features but different prognostic and treatment implications. Distinction between them is not always straightforward. We com…
View article: The immune-related microRNA miR-146b is upregulated in glioblastoma recurrence
The immune-related microRNA miR-146b is upregulated in glioblastoma recurrence Open
Genome-wide expression profiling identifies multiple oncologic and immune-related gene sets associated with GBM recurrence. In particular, immune-related miR-146b is upregulated in recurrence and deserves further investigation.
View article: Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis
Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis Open
Adult brainstem gliomas are difficult to classify based on radiologic and histologic features. A K27M mutation in histone 3 has been described to identify high-grade midline gliomas associated with a particularly unfavorable prognosis. Whi…
View article: Additional file 1: of Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients
Additional file 1: of Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients Open
Clinical, epidemiological and pathological features of nerve and muscle biopsies included in this study. (XLSX 43Â kb)