Huichuan Yu
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View article: Bevacizumab plus chemotherapy versus chemotherapy in untreated advanced non-squamous non-small-cell lung cancer patients with brain metastases (BAP BRAIN): an open-label, randomized, multicenter, phase III study
Bevacizumab plus chemotherapy versus chemotherapy in untreated advanced non-squamous non-small-cell lung cancer patients with brain metastases (BAP BRAIN): an open-label, randomized, multicenter, phase III study Open
This study demonstrated encouraging intracranial efficacy and acceptable safety of bevacizumab plus chemotherapy in patients with non-squamous NSCLC and brain metastases in the first-line setting.
View article: Transcriptomic profile of RNA pseudouridine modification as a biomarker for cellular senescence associated with survival outcomes in colorectal cancer
Transcriptomic profile of RNA pseudouridine modification as a biomarker for cellular senescence associated with survival outcomes in colorectal cancer Open
Overall, these findings reveal that RNA Ψ modification connected aging and cancer and provided novel insights into biomarker-guided cancer regimens.
View article: Is intraperitoneal isoperistaltic side-to-side anastomosis a safe surgical procedure in radical colon cancer surgery
Is intraperitoneal isoperistaltic side-to-side anastomosis a safe surgical procedure in radical colon cancer surgery Open
BACKGROUND Colorectal cancer, one of the most common malignancies, is primarily treated through surgery. With the widespread use of laparoscopy, gastrointestinal reconstruction remains a key area of research. The choice between intraperito…
View article: Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade
Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade Open
Background Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer‐associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, …
View article: Replenishment of mitochondrial Na+ and H+ by ionophores potentiates cutaneous wound healing in diabetes
Replenishment of mitochondrial Na+ and H+ by ionophores potentiates cutaneous wound healing in diabetes Open
Diabetic foot ulcer (DFU) is a highly morbid complication in patients with diabetes mellitus, necessitating the development of innovative pharmaceuticals to address unmet medical needs. Sodium ion (Na+) is a well-established mediator for m…
View article: RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner Open
Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) is a well‐described m6A demethylase in previous enzyme assays, we aimed to investig…
View article: Aberrant methylation in neurofunctional gene serves as a hallmark of tumorigenesis and progression in colorectal cancer
Aberrant methylation in neurofunctional gene serves as a hallmark of tumorigenesis and progression in colorectal cancer Open
Background DNA methylation is one of the most promising biomarkers in predicting the prognosis of colorectal cancer (CRC). We aimed to develop a DNA methylation biomarker that could evaluate the prognosis of CRC. Methods A promising DNA me…
View article: Supplementary Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Supplementary Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer Open
Supplemental Figures 1-10 and Reagent table
View article: Supplementary Table 1 from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Supplementary Table 1 from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer Open
Table S1. The distribution and calculated pI of peptides in the peptide arrays
View article: Supplementary Table 1 from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Supplementary Table 1 from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer Open
Table S1. The distribution and calculated pI of peptides in the peptide arrays
View article: Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer Open
DNA methylation contributes to malignant transformation, but little is known about how the methylation drives colorectal cancer evolution at the early stages. Here we identify aberrant INA (α-internexin) gene methylation in colon adenoma a…
View article: Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer Open
DNA methylation contributes to malignant transformation, but little is known about how the methylation drives colorectal cancer evolution at the early stages. Here we identify aberrant INA (α-internexin) gene methylation in colon adenoma a…
View article: Supplementary Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer
Supplementary Data from Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer Open
Supplemental Figures 1-10 and Reagent table
View article: Radiological lymph‐node size improves the prognostic value of systemic inflammation index in rectal cancer with pathologically negative nodes
Radiological lymph‐node size improves the prognostic value of systemic inflammation index in rectal cancer with pathologically negative nodes Open
Background The relationship between the radiological lymph node (rLN) size and survival outcome in node‐negative rectal cancer is still uncertain. In this study, we aimed to explore the role of enlarged rLN in predicting the survival of no…
View article: Pan-cancer investigation of C-to-U editing reveals its important role in cancer development and new targets for cancer treatment
Pan-cancer investigation of C-to-U editing reveals its important role in cancer development and new targets for cancer treatment Open
RNA editing is prevalent in the transcriptome and is important for multiple cellular processes. C-to-U RNA editing sites (RES) are relatively rare and understudied in humans, compared to A-to-I editing. However, the functional impact of C-…
View article: Prevalent Pseudoprogression and Pseudoresidue in Patients With Rectal Cancer Treated With Neoadjuvant Immune Checkpoint Inhibitors
Prevalent Pseudoprogression and Pseudoresidue in Patients With Rectal Cancer Treated With Neoadjuvant Immune Checkpoint Inhibitors Open
Background: Immune checkpoint inhibitor (ICI) treatment in patients with microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) tumors holds promise in reshaping organ preservation in rectal cancer. However, the benefits ar…
View article: Cover Image
Cover Image Open
The cover image is based on the Research Article Clinical spectrum of rectal cancer identifies hallmarks of early-onset patients and next-generation treatment strategies by Dingcheng Shen et al., https://doi.org/10.1002/cam4.5120.
View article: Automatic treatment outcome prediction with DeepInteg based on multimodal radiological images in rectal cancer
Automatic treatment outcome prediction with DeepInteg based on multimodal radiological images in rectal cancer Open
Neoadjuvant systemic treatment before surgery is a prevalent regimen in the patients with advanced-stage or high-risk tumor, which has shaped the treatment strategies and cancer survival in the past decades. However, some patients present …
View article: Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages Open
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as a proto-oncogene in multiple cancers. The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype…
View article: DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer
DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer Open
Background The current risk stratification system defined by clinicopathological features does not identify the risk of recurrence in early-stage (stage I-II) colorectal cancer (CRC) with sufficient accuracy. We aimed to investigate whethe…
View article: Clinical spectrum of rectal cancer identifies hallmarks of early‐onset patients and next‐generation treatment strategies
Clinical spectrum of rectal cancer identifies hallmarks of early‐onset patients and next‐generation treatment strategies Open
Background The incidence of colorectal cancer is increasing among young adults and more rectal cancers are reported. This study aimed to identify the clinical features specific for early‐onset rectal cancer and provide insights on cancer m…