Yuto Hamada
YOU?
Author Swipe
View article: Treatment response trajectories for speech pathology intervention in chronic cough
Treatment response trajectories for speech pathology intervention in chronic cough Open
Background Speech pathology intervention is an effective treatment for refractory and unexplained chronic cough (RUCC), however data regarding treatment outcomes in real-world settings is limited. Similarly, the influence of cough phenotyp…
View article: Release of HMGB1 from human-derived cancer and normal cells by internal targeted radiotherapy with 131I-<i>meta</i>-iodobenzylguanidine
Release of HMGB1 from human-derived cancer and normal cells by internal targeted radiotherapy with 131I-<i>meta</i>-iodobenzylguanidine Open
The rare abscopal effect in radiotherapy is thought to result from immune-activating damage-associated molecular patterns, such as high mobility group box-1 protein (HMGB1), released from cancer cells. While external irradiation of cancer …
View article: Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion
Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion Open
Treatment targets in severe asthma have evolved towards a remission‐focused paradigm guided by precision medicine. This novel concept requires a shift from evaluating the efficacy of therapies based on a single outcome at a single time poi…
View article: Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma
Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma Open
Core extrapulmonary and behavior/risk factor traits in T2-high severe asthma were dysfunctional breathing and depression, contributing to worse asthma outcomes, suggesting that core TTs may differ between asthma inflammatory phenotypes. El…
View article: IgE-Crosslinking-Induced Luciferase Expression Test as a Sensitive Indicator of Anisakis Allergy
IgE-Crosslinking-Induced Luciferase Expression Test as a Sensitive Indicator of Anisakis Allergy Open
Background: Anisakis allergy has been increasing, and the diagnosis of it is based on specific serum IgE detection. Recently, the IgE-crosslinking-induced luciferase expression (EXiLE) test has been proposed as convenient tool for detectin…
View article: MeTrEx: Membrane Trajectory Explorer
MeTrEx: Membrane Trajectory Explorer Open
Background: Molecular Dynamics (MD) simulations provide valuable insights into the behaviour of biomolecules, particularly in complex systems such as cellular membranes. However, the increasing volume of MD data presents significant challe…
View article: IgE Crosslinking-Induced Luciferase Expression Test as a Sensitive Indicator of Anisakis Allergy
IgE Crosslinking-Induced Luciferase Expression Test as a Sensitive Indicator of Anisakis Allergy Open
Anisakis allergy has been increasing and the diagnosis of it is based on specific serum IgE detection. Recently, IgE crosslinking-induced luciferase expression (EXiLE) test has been proposed as convenient tool for detecting the functional …
View article: Release of HMGB1 from Human-Derived Cancer and Normal Cells by Internal Targeted Radiotherapy with <sup>131</sup>Iodine-Labeled <em>m</em>-Iodobenzylguanidine
Release of HMGB1 from Human-Derived Cancer and Normal Cells by Internal Targeted Radiotherapy with <sup>131</sup>Iodine-Labeled <em>m</em>-Iodobenzylguanidine Open
The rare abscopal effect during radiotherapy is thought to be caused by the release of immune-stimulated damage-associated molecular patterns, such as high mobility group box-1 protein (HMGB1), from cancer cells. Although external irradiat…
View article: A treatable traits approach for asthma in a post-COVID era
A treatable traits approach for asthma in a post-COVID era Open
As a novel respiratory viral infection, coronavirus disease 2019 (COVID-19) has influenced asthma in unpredictable ways. In the post-COVID era, there is a need to review asthma care and the new challenges and opportunities that are present…
View article: Metagenomic gut microbiome analysis of Japanese patients with multiple chemical sensitivity/idiopathic environmental intolerance
Metagenomic gut microbiome analysis of Japanese patients with multiple chemical sensitivity/idiopathic environmental intolerance Open
Background Although the pathology of multiple chemical sensitivity (MCS) is unknown, the central nervous system is reportedly involved. The gut microbiota is important in modifying central nervous system diseases. However, the relationship…
View article: Uncovering a Severe Patient Group With Pollen-Related Extrarespiratory Allergic Symptoms: A Year-Long Diary Survey in Japan
Uncovering a Severe Patient Group With Pollen-Related Extrarespiratory Allergic Symptoms: A Year-Long Diary Survey in Japan Open
This 1-year survey identified a small but nonnegligible group of patients with pollen-related extrarespiratory symptoms. More attention should be paid to this patient group considering their impaired activity and work productivity.
View article: Anisakis allergy versus gastric anisakiasis: A case of repeated Anisakis-associated symptoms
Anisakis allergy versus gastric anisakiasis: A case of repeated Anisakis-associated symptoms Open
A 53-year-old patient experienced 2 Anisakis-induced allergic episodes: the first with anaphylaxis, the second presenting with gastric symptoms and progressing to systemic anaphylaxis. The case could suggest a common pathophysiology involv…
View article: Computed tomography findings of paranasal sinuses in patients with eosinophilic granulomatosis with polyangiitis: Comparison with other eosinophilic sinus diseases and clinical relevance of their severity
Computed tomography findings of paranasal sinuses in patients with eosinophilic granulomatosis with polyangiitis: Comparison with other eosinophilic sinus diseases and clinical relevance of their severity Open
Although paranasal sinus lesions in EGPA were less severe than those of other eosinophilic sinus diseases, their milder CT findings may be associated with a higher frequency of extra-respiratory organ involvement.
View article: Longitudinal changes in the prevalence of adult asthma: An epidemiological survey among Japanese salaried employees and their dependents using healthcare insurance claim from 1999 to 2019
Longitudinal changes in the prevalence of adult asthma: An epidemiological survey among Japanese salaried employees and their dependents using healthcare insurance claim from 1999 to 2019 Open
The prevalence of adult asthma among Japanese salaried employees and their dependents has increased over the last 20 years, suggesting more attention should be paid to the prevention of this disease in adults.
View article: Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure
Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure Open
Cumulative lifetime OCS exposure was associated with a higher prevalence of frailty and muscle weakness. These findings emphasize the importance of minimizing lifetime OCS exposure for the prolongation of healthy life expectancy in patient…
View article: P21: NOT FOR PUBLICATION
P21: NOT FOR PUBLICATION Open
immunologist's discretion.Challenge eligibility was based on clinical history
View article: P22: NOT FOR PUBLICATION
P22: NOT FOR PUBLICATION Open
immunologist's discretion.Challenge eligibility was based on clinical history
View article: P27: NOT FOR PUBLICATION
P27: NOT FOR PUBLICATION Open
immunologist's discretion.Challenge eligibility was based on clinical history
View article: P26: NOT FOR PUBLICATION
P26: NOT FOR PUBLICATION Open
immunologist's discretion.Challenge eligibility was based on clinical history
View article: P24: RAW SEAFOOD, NOT COOKED, IS A RISK FACTOR FOR THE RECURRENCE OF ANAPHYLAXIS IN PATIENTS WITH ANISAKIS ALLERGY: A RETROSPECTIVE OBSERVATIONAL STUDY IN JAPAN
P24: RAW SEAFOOD, NOT COOKED, IS A RISK FACTOR FOR THE RECURRENCE OF ANAPHYLAXIS IN PATIENTS WITH ANISAKIS ALLERGY: A RETROSPECTIVE OBSERVATIONAL STUDY IN JAPAN Open
immunologist's discretion.Challenge eligibility was based on clinical history
View article: P23: FOOD PROTEIN‐INDUCED ENTEROCOLITIS SYNDROME IN AN AUSTRALIAN REGIONAL CENTRE
P23: FOOD PROTEIN‐INDUCED ENTEROCOLITIS SYNDROME IN AN AUSTRALIAN REGIONAL CENTRE Open
immunologist's discretion.Challenge eligibility was based on clinical history
View article: Identification of fungi causing humidifier lung: 2 rare cases and a review of the literature
Identification of fungi causing humidifier lung: 2 rare cases and a review of the literature Open
Background Humidifier lung (HL) is a hypersensitivity pneumonitis resulting from exposure to humidifiers, with fungi from the humidifier as one of the etiologic agents. However, identification of the fungal species responsible for each cas…
View article: Identification of asthma cases in Japan using health insurance claims data: Positive and negative predictive values of proposed discrimination criteria: A single-center study
Identification of asthma cases in Japan using health insurance claims data: Positive and negative predictive values of proposed discrimination criteria: A single-center study Open
Our proposed criteria adequately identified asthma subjects using health insurance claims data in Japan with a high PPV. Further studies are needed for external validation of these criteria.
View article: Miliary pattern on chest imaging caused by adenocarcinoma
Miliary pattern on chest imaging caused by adenocarcinoma Open
A 55-year-old, nonsmoking woman without underlying disease presented to the emergency department with a 3-month history of productive cough, dyspnea, night sweats and 4 kg weight loss. On examination, her temperature was 36.8°C, heart rate…
View article: Steroid resistance of severe asthma - mechanisms and therapeutic targets
Steroid resistance of severe asthma - mechanisms and therapeutic targets Open
Asthma therapy in general has improved a lot in recent years, but it is still a major problem that severe asthma, which accounts for 10 to 20%, still suffers from strong symptoms on a daily basis despite all therapeutic agents used in comb…
View article: Low-dose mepolizumab is effective as an add-on therapy for treating long-lasting peripheral neuropathy in patients with eosinophilic granulomatosis with polyangiitis
Low-dose mepolizumab is effective as an add-on therapy for treating long-lasting peripheral neuropathy in patients with eosinophilic granulomatosis with polyangiitis Open
Objective To assess the effectiveness of low-dose mepolizumab as an add-on therapy for treating peripheral neurological symptoms in eosinophilic granulomatosis with polyangiitis (EGPA). Methods We prospectively studied 13 EGPA patients wit…