Yu-Hsiang Tu
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View article: Loss of Otopetrin 1 affects thermoregulation during fasting in mice
Loss of Otopetrin 1 affects thermoregulation during fasting in mice Open
Objective Otopetrin 1 (OTOP1) is a proton channel that is highly expressed in brown adipose tissue. We examined the physiology of Otop1 -/- mice, which lack functional OTOP1. Methods Mice were studied by indirect calorimetry and telemetric…
View article: Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels
Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels Open
Otopetrin (OTOP) channels are proton-selective ion channels conserved among vertebrates and invertebrates, with no structural similarity to other ion channels. There are three vertebrate OTOP channels (OTOP1, OTOP2, and OTOP3), of which on…
View article: Author response: Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels
Author response: Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Otopetrin (OTOP) chann…
View article: Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels
Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels Open
Otopetrin (OTOP) channels are proton-selective ion channels conserved among vertebrates and invertebrates and with no structural similarity to other ion channels. There are three vertebrate OTOP channels (OTOP1, OTOP2, and OTOP3), of which…
View article: Structures of the Otopetrin Proton Channels Otop1 and Otop3
Structures of the Otopetrin Proton Channels Otop1 and Otop3 Open
Otopetrins (Otop1-Otop3) comprise one of only two known eukaryotic proton-selective channel families. Otop1 is required for formation of otoconia and is a candidate mammalian sour taste receptor. Here, we report cryo-EM structures of zebra…
View article: Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers
Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers Open
The nociceptor ion channel TRPA1 detects a wide range of hazardous chemicals, including reactive electrophiles such as cinnamaldehyde, which gate the channel allowing Na + and Ca 2+ entry. TRPA1 assembles as a tetramer, with a central pore…