Yu‐Chien Wu
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View article: The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment
The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment Open
Background Mild cognitive impairment (MCI) has been related to impairment in cerebrovascular perfusion and microstructural magnetic resonance imaging (MRI) parameters. However, the relationship between cerebrovascular perfusion and microst…
View article: Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults
Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults Open
Human brains undergo considerable morphologic variation with age, a primary risk factor for neurodegenerative disorders. While aging often causes neurocognitive decline, its governing biological mechanisms remain unclear. These age-related…
View article: Relationship between Perivascular Space Burden, White Matter Hyperintensities, and Cognitive Function
Relationship between Perivascular Space Burden, White Matter Hyperintensities, and Cognitive Function Open
Introduction: Perivascular space (PVS) is believed to be involved in clearing metabolic waste from the brain. PVS has been found to increase in size in patients with Alzheimer’s disease, but the relationship between PVS enlargement and cog…
View article: Investigating the Associations Between the Perivascular Space, Age, and Cognitive Function in Cognitively Normal and Impaired Individuals
Investigating the Associations Between the Perivascular Space, Age, and Cognitive Function in Cognitively Normal and Impaired Individuals Open
Background and Hypothesis: Perivascular spaces (PVS) are a component of the glymphatic system, which is believed to help remove waste products from the brain. Dilated PVS have been correlated with normal aging and neurological conditions. …
View article: 515 Targeting negative-self-referential processing with transcranial magnetic stimulation: Feasibility studies
515 Targeting negative-self-referential processing with transcranial magnetic stimulation: Feasibility studies Open
Objectives/Goals: Neuromodulation strategies like transcranial magnetic stimulation (TMS) can target specific neural circuits underlying particular psychiatric symptoms, potentially 1) enhancing understanding of mechanisms of illness and r…
View article: Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study
Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study Open
Background: This study used diffusion tensor imaging (DTI) to detect brain microstructural changes in participants with mild traumatic brain injury (mTBI) who experienced post-traumatic headaches, a common issue that affects quality of lif…
View article: Dynamic diffusion-weighted imaging of intracranial cardiac impulse propagation along arteries to arterioles in the aging brain
Dynamic diffusion-weighted imaging of intracranial cardiac impulse propagation along arteries to arterioles in the aging brain Open
Intracranial cardiac impulse propagation along penetrating arterioles is vital for both nutrient supply via blood circulation and waste clearance via CSF circulation. However, current neuroimaging methods are limited to simultaneously dete…
View article: Association of Alzheimer’s Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics
Association of Alzheimer’s Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics Open
View article: Mapping alterations in the hippocampal subfields in the ARTE10 mouse model of Alzheimer's disease using dMRI derived soma and neurite density maps
Mapping alterations in the hippocampal subfields in the ARTE10 mouse model of Alzheimer's disease using dMRI derived soma and neurite density maps Open
Background The hippocampus, a region vital for memory and cognition, is prone to abnormal deposition of beta‐amyloid (Aß) during the early stages of the Alzheimer’s disease. Aß‐associated pathophysiological mechanisms instigate dendritic d…
View article: Mapping alterations in the hippocampal subfields in the ARTE10 mouse model of Alzheimer’s disease using dMRI derived soma and neurite density maps
Mapping alterations in the hippocampal subfields in the ARTE10 mouse model of Alzheimer’s disease using dMRI derived soma and neurite density maps Open
Background The hippocampus, a region vital for memory and cognition, is prone to abnormal deposition of beta‐amyloid (Aβ) during the early stages of the Alzheimer’s disease. Aβ‐associated pathophysiological mechanisms instigate dendritic d…
View article: Association of Alzheimer’s disease polygenic risk score with concussion severity and recovery metrics
Association of Alzheimer’s disease polygenic risk score with concussion severity and recovery metrics Open
Background Shared genetic risk between Alzheimer’s disease (AD) and concussion may help explain the association between concussion and elevated risk for dementia. However, there has been little investigation into whether AD risk genes also…
View article: Verbal training can improve neurocognitive and reading performance by increasing white matter integrity and grey matter volume
Verbal training can improve neurocognitive and reading performance by increasing white matter integrity and grey matter volume Open
The study demonstrates that a 4-week verbal articulation training intervention period can lead to significant improvements in grey matter volume in the left Supplementary motor area, the left Postcentral gyrus, and the bilateral Superior f…
View article: Coupled pulsatile vascular and paravascular fluid dynamics in the human brain
Coupled pulsatile vascular and paravascular fluid dynamics in the human brain Open
View article: White matter microstructural changes in post-traumatic headache: A diffusion tensor imaging (DTI) study
White matter microstructural changes in post-traumatic headache: A diffusion tensor imaging (DTI) study Open
Introduction Post-traumatic headache (PTH) is a common consequence of mild traumatic brain injury (mTBI) that can severely impact an individual’s quality of life and rehabilitation. However, the underlying neuropathogenesis mechanisms cont…
View article: Biclustering Multivariate Longitudinal Data with Application to Recovery Trajectories of White Matter After Sport-Related Concussion
Biclustering Multivariate Longitudinal Data with Application to Recovery Trajectories of White Matter After Sport-Related Concussion Open
Biclustering is the task of simultaneously clustering the samples and features of a data set. In doing so, subsets of samples that exhibit similar behaviors across subsets of features can be identified. Motivated by a longitudinal diffusio…
View article: Association of Alzheimer’s disease polygenic risk score with concussion severity and recovery metrics
Association of Alzheimer’s disease polygenic risk score with concussion severity and recovery metrics Open
Identification of genetic alleles associated with both Alzheimer’s disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation…
View article: Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements
Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements Open
Cerebrospinal fluid (CSF) plays a critical role in metabolic waste clearance from the brain, requiring its circulation throughout various brain pathways, including the ventricular system, subarachnoid spaces, para‐arterial spaces, intersti…
View article: Estimating the synaptic density deficit in Alzheimer’s disease using multi-contrast CEST imaging
Estimating the synaptic density deficit in Alzheimer’s disease using multi-contrast CEST imaging Open
In vivo noninvasive imaging of neurometabolites is crucial to improve our understanding of the underlying pathophysiological mechanism in neurodegenerative diseases. Abnormal changes in synaptic organization leading to synaptic degradation…
View article: Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease
Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease Open
View article: Sex differences in region-specific hippocampal areas in Alzheimer’s Disease: an animal-based approach
Sex differences in region-specific hippocampal areas in Alzheimer’s Disease: an animal-based approach Open
Background: Atrophy in the hippocampus is responsible for memory and cognitive decline in Alzheimer’s Disease (AD). Progression and presentation of AD in men and women are different, and the hippocampus and its subregions could be affected…
View article: Longitudinal Effects of Aging on Microstructure of the Hippocampal Subfields
Longitudinal Effects of Aging on Microstructure of the Hippocampal Subfields Open
View article: Exploring Radial Asymmetry in <scp>MR</scp> Diffusion Tensor Imaging and Its Impact on the Interpretation of Glymphatic Mechanisms
Exploring Radial Asymmetry in <span>MR</span> Diffusion Tensor Imaging and Its Impact on the Interpretation of Glymphatic Mechanisms Open
Background Diffusion imaging holds great potential for the non‐invasive assessment of the glymphatic system in humans. One technique, diffusion tensor imaging along the perivascular space (DTI‐ALPS), has introduced the ALPS‐index, a novel …
View article: White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum
White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum Open
Background White matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimer’s disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations. Methods We assessed…
View article: BrainAGE Estimation: Influence of Field Strength, Voxel Size, Race, and Ethnicity
BrainAGE Estimation: Influence of Field Strength, Voxel Size, Race, and Ethnicity Open
The BrainAGE method is used to estimate biological brain age using structural neuroimaging. However, the stability of the model across different scan parameters and races/ethnicities has not been thoroughly investigated. Estimated brain ag…
View article: The Effects of Hypertension on White Matter Microstructural and Vascular Imaging Metrics
The Effects of Hypertension on White Matter Microstructural and Vascular Imaging Metrics Open
Background Hypertension is one of the key vascular risk factors of AD and related dementia. Cerebral blood flow (CBF) and white matter (WM) integrity may play an essential role in understanding the vascular contributions to dementia (VCID)…
View article: Longitudinal age effects in microstructures of the hippocampal subfields
Longitudinal age effects in microstructures of the hippocampal subfields Open
Background The human brain undergoes considerable morphologic change with age, which is one of the primary risk‐factors for Alzheimer’s disease (AD). Age‐related microstructural changes in the brain may be quantified by advanced diffusion …
View article: The Effects of Hypertension on White Matter Microstructural and Vascular Imaging Metrics
The Effects of Hypertension on White Matter Microstructural and Vascular Imaging Metrics Open
Background Hypertension is one of the key vascular risk factors of AD and related dementia. Cerebral blood flow (CBF) and white matter (WM) integrity may play an essential role in understanding the vascular contributions to dementia (VCID)…
View article: Longitudinal age effects in microstructures of the hippocampal subfields.
Longitudinal age effects in microstructures of the hippocampal subfields. Open
Background The human brain undergoes considerable morphologic change with age, which is one of the primary risk‐factors for Alzheimer’s disease (AD). Age‐related microstructural changes in the brain may be quantified by advanced diffusion …
View article: Relationship of diffusion weighted imaging of the hippocampal cingulum and cognition across the Alzheimer’s disease continuum
Relationship of diffusion weighted imaging of the hippocampal cingulum and cognition across the Alzheimer’s disease continuum Open
Background Diffusion tensor imaging (DTI) measures water diffusion within brain tissue and can provide information regarding white matter, myelin, and axonal degeneration. We analyzed the cingulum bundle of the hippocampus (CBH), chosen fo…
View article: Neuroimaging of new and novel Alzheimer’s Disease (AD) mice from the MODEL AD Consortium
Neuroimaging of new and novel Alzheimer’s Disease (AD) mice from the MODEL AD Consortium Open
Background The ability of preclinical neuroimaging in rodent models of Alzheimer’s Disease and Related Dementia (ADRD) to assess the progression of disease is increasingly providing novel insights into AD, like human AD imaging. Preclinica…