Ya-Yu Tsai
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View article: Successful response in advanced leptomeningeal disease from pleomorphic xanthoastrocytoma with BRAF/MEK inhibitors: a case report
Successful response in advanced leptomeningeal disease from pleomorphic xanthoastrocytoma with BRAF/MEK inhibitors: a case report Open
Leptomeningeal disease (LMD) is a rare metastatic complication with a grim prognosis for most patients and limited treatment strategies. Therapy is adjusted to the primary tumor from which it arises. Targeted therapies and personalized med…
View article: OS04.6.A MULTICENTER RANDOMIZED PHASE II STUDY OF R-MPV-A CHEMOIMMUNOTHERAPY WITH OR WITHOUT LOW-DOSE WHOLE-BRAIN RADIOTHERAPY FOR NEWLY DIAGNOSED PRIMARY CNS LYMPHOMA: NRG/ RTOG 1114
OS04.6.A MULTICENTER RANDOMIZED PHASE II STUDY OF R-MPV-A CHEMOIMMUNOTHERAPY WITH OR WITHOUT LOW-DOSE WHOLE-BRAIN RADIOTHERAPY FOR NEWLY DIAGNOSED PRIMARY CNS LYMPHOMA: NRG/ RTOG 1114 Open
BACKGROUND Methotrexate-based chemoradiotherapy is effective in primary central nervous system lymphoma (PCNSL), but carries a risk of severe neurotoxicity. In a single-arm study, a chemotherapy regimen with methotrexate, procarbazine, vin…
View article: Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer
Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer Open
Background Cancer-related fatigue (fatigue) is a common and persistent symptom after cancer treatment, yet the role of genetic susceptibility remains unclear. Methods We used data from a prospective cohort study called the ColoCare Study, …
View article: SUPC-01 SURVIVAL AND PROGNOSTIC FACTORS IN HOSPITALIZED PATIENTS WITH LEPTOMENINGEAL DISEASE: A RETROSPECTIVE REVIEW OF PALLIATIVE RADIOTHERAPY
SUPC-01 SURVIVAL AND PROGNOSTIC FACTORS IN HOSPITALIZED PATIENTS WITH LEPTOMENINGEAL DISEASE: A RETROSPECTIVE REVIEW OF PALLIATIVE RADIOTHERAPY Open
BACKGROUND Leptomeningeal disease (LMD) is associated with poor prognosis, and effective management requires a multidisciplinary approach. Limited data exist on stratifying patients for therapy and prognosis. We endeavor to describe our in…
View article: The relationship between metabolic syndrome and environmental endocrine disruptors: A systematic review and meta-analysis
The relationship between metabolic syndrome and environmental endocrine disruptors: A systematic review and meta-analysis Open
Metabolic syndrome (MetS) is considered to be an important factor leading to an increased risk of chronic non-communicable diseases. Studies have found that exposure to environmental endocrine disruptors (EEDs) is associated with MetS, but…
View article: Phagocytosis‐Activating Nanocomplex Orchestrates Macrophage‐Mediated Cancer Immunotherapy
Phagocytosis‐Activating Nanocomplex Orchestrates Macrophage‐Mediated Cancer Immunotherapy Open
The phagocytosis of macrophages to tumor cells represents an alluring strategy for cancer immunotherapy; however, its effectiveness is largely hindered by the detrimental upregulation of anti‐phagocytic signals and insufficient expression …
View article: Nivolumab and stereotactic radiosurgery for patients with breast cancer brain metastases: long-term results and biomarker analysis from a non-randomized, open-label, phase Ib study
Nivolumab and stereotactic radiosurgery for patients with breast cancer brain metastases: long-term results and biomarker analysis from a non-randomized, open-label, phase Ib study Open
Background We hypothesized treatment with nivolumab and stereotactic radiosurgery (SRS) would be feasible, well tolerated, and may improve intracranial tumor control over SRS alone for breast cancer brain metastases (BCBM). Methods The stu…
View article: Building research infrastructure to advance precision medicine in colorectal cancer
Building research infrastructure to advance precision medicine in colorectal cancer Open
Background Addressing critical gaps in precision medicine initiatives in colorectal cancer (CRC) requires building larger collaborative studies. Methods The Latino Colorectal Cancer Consortium (LC3) is a resource that harmonizes data colle…
View article: A Rare Case of Simultaneous Brain and Leptomeningeal Metastases in a Patient With Pancreatic Cancer
A Rare Case of Simultaneous Brain and Leptomeningeal Metastases in a Patient With Pancreatic Cancer Open
View article: Simplifying post-operative radiotherapy for bone metastases
Simplifying post-operative radiotherapy for bone metastases Open
The delivery of post-operative radiotherapy (PORT) for solid tumor bone metastases is a well-established practice that aims to enhance patient outcomes following surgical intervention. Surgery for osseous metastases serves to stabilize bon…
View article: Intricacies of human–AI interaction in dynamic decision-making for precision oncology
Intricacies of human–AI interaction in dynamic decision-making for precision oncology Open
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals’ cancer progression for effective personalized care. However, AI’s imperfections can lead to suboptimal t…
View article: Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas
Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas Open
Background Our previous clinical investigation suggested that hypofractionated stereotactic re-irradiation (HFSRT) and PD-1 blockade may act synergistically to enhance the immune response against glioma. This subsequent trial investigated …
View article: A sample size analysis of a mathematical model of longitudinal tumor volume and progression‐free survival for Bayesian individual dynamic predictions in recurrent high‐grade glioma
A sample size analysis of a mathematical model of longitudinal tumor volume and progression‐free survival for Bayesian individual dynamic predictions in recurrent high‐grade glioma Open
Patients with recurrent high‐grade glioma (rHGG) have a poor prognosis with median progression‐free survival (PFS) of <7 months. Responses to treatment are heterogenous, suggesting a clinical need for prognostic models. Bayesian data analy…
View article: Multi-institutional report of trastuzumab deruxtecan and stereotactic radiosurgery for HER2 positive and HER2-low breast cancer brain metastases
Multi-institutional report of trastuzumab deruxtecan and stereotactic radiosurgery for HER2 positive and HER2-low breast cancer brain metastases Open
Trastuzumab-deruxtecan (T-DXd) has demonstrated intracranial efficacy; however, safety and efficacy data remains limited with stereotactic radiosurgery (SRS). A multi-institutional review was performed with HER2+ or HER2-low metastatic bre…
View article: Differences in tumor-associated T-cell receptor repertoires between early-onset and average-onset colorectal cancer
Differences in tumor-associated T-cell receptor repertoires between early-onset and average-onset colorectal cancer Open
The incidence of colorectal cancer (CRC) among individuals younger than age 50 (early-onset CRC [EOCRC]) has substantially increased, and yet the etiology and molecular mechanisms underlying this alarming rise remain unclear. We compared t…
View article: Intricacies of Human-AI Interaction in Dynamic Decision-Making for Precision Oncology: A Case Study in Response-Adaptive Radiotherapy
Intricacies of Human-AI Interaction in Dynamic Decision-Making for Precision Oncology: A Case Study in Response-Adaptive Radiotherapy Open
Background Adaptive treatment strategies that can dynamically react to individual cancer progression can provide effective personalized care. Longitudinal multi-omics information, paired with an artificially intelligent clinical decision s…
View article: Germline genetic regulation of the colorectal tumor immune microenvironment
Germline genetic regulation of the colorectal tumor immune microenvironment Open
Objective To evaluate the contribution of germline genetics to regulating the briskness and diversity of T cell responses in CRC, we conducted a genome-wide association study to examine the associations between germline genetic variation a…
View article: MODL-06. THE GUT MICROBIOTA OF BRAIN TUMOR PATIENTS CAN IMPACT IMMUNOTHERAPY EFFICACY IN A PRECLINICAL MODEL OF GLIOMA
MODL-06. THE GUT MICROBIOTA OF BRAIN TUMOR PATIENTS CAN IMPACT IMMUNOTHERAPY EFFICACY IN A PRECLINICAL MODEL OF GLIOMA Open
Combination immune checkpoint inhibitors (ICI) can affect durable response in melanoma brain metastases (MBM) but have largely been ineffective for the treatment of glioblastoma (GBM), a primary brain tumor. Recent studies in animal models…
View article: RADT-07. CLINICAL OUTCOMES OF MELANOMA BRAIN METASTASES TREATED WITH NIVOLUMAB AND IPILIMUMAB ALONE VERSUS NIVOLUMAB AND IPILIMUMAB WITH STEREOTACTIC RADIOSURGERY
RADT-07. CLINICAL OUTCOMES OF MELANOMA BRAIN METASTASES TREATED WITH NIVOLUMAB AND IPILIMUMAB ALONE VERSUS NIVOLUMAB AND IPILIMUMAB WITH STEREOTACTIC RADIOSURGERY Open
BACKGROUND Upfront dual checkpoint blockade has demonstrated efficacy in new melanoma brain metastases (MBM) of asymptomatic patients. Whether combination stereotactic radiosurgery (SRS) with dual checkpoint blockade improves outcomes over…
View article: SURG-26. HYDROCEPHALUS IN LEPTOMENINGEAL DISEASE: TANDEM OMMAYA RESERVOIR-SHUNT FOR INTRATHECAL CHEMOTHERAPY ADMINISTRATION
SURG-26. HYDROCEPHALUS IN LEPTOMENINGEAL DISEASE: TANDEM OMMAYA RESERVOIR-SHUNT FOR INTRATHECAL CHEMOTHERAPY ADMINISTRATION Open
INTRODUCTION Leptomeningeal disease (LMD) is a rare late-stage manifestation of disease progression in solid and hematologic malignancies. Although advances in intrathecal therapeutic (IT) provide treatment options beyond the traditional W…
View article: CTIM-01. NIVOLUMAB AND STEREOTACTIC RADIOSURGERY (SRS) FOR PATIENTS WITH BREAST CANCER BRAIN METASTASES: LONG TERM RESULTS AND CELL FREE DNA (CFDNA) ASSESSMENT FROM A NON-RANDOMIZED, OPEN-LABEL, PHASE IB STUDY
CTIM-01. NIVOLUMAB AND STEREOTACTIC RADIOSURGERY (SRS) FOR PATIENTS WITH BREAST CANCER BRAIN METASTASES: LONG TERM RESULTS AND CELL FREE DNA (CFDNA) ASSESSMENT FROM A NON-RANDOMIZED, OPEN-LABEL, PHASE IB STUDY Open
BACKGROUND We hypothesized treatment with nivolumab and SRS would be feasible and well tolerated and may improve intracranial tumor control over SRS alone for breast cancer brain metastases. METHODS The study is a phase Ib trial of nivolum…
View article: RADT-09. CLINICAL OUTCOMES OF FRACTIONATED STEREOTACTIC RADIOTHERAPY FOR INTACT AND POSTOPERATIVE RADIORESISTANT RENAL CELL CARCINOMA AND MELANOMA BRAIN METASTASES
RADT-09. CLINICAL OUTCOMES OF FRACTIONATED STEREOTACTIC RADIOTHERAPY FOR INTACT AND POSTOPERATIVE RADIORESISTANT RENAL CELL CARCINOMA AND MELANOMA BRAIN METASTASES Open
PURPOSE Fractionated Stereotactic Radiotherapy (FSRT) may be an optimal strategy for radioresistant renal cell carcinoma (RCC) and melanoma brain metastases (BM). We reviewed our institutional experience of FSRT to intact BM and postoperat…
View article: CTNI-04. PHASE I STUDY OF RADIATION THERAPY (RT) FOLLOWED BY INTRATHECAL (IT) TRASTUZUMAB/PERTUZUMAB IN THE MANAGEMENT OF HER2+ BREAST LEPTOMENINGEAL DISEASE (LMD)
CTNI-04. PHASE I STUDY OF RADIATION THERAPY (RT) FOLLOWED BY INTRATHECAL (IT) TRASTUZUMAB/PERTUZUMAB IN THE MANAGEMENT OF HER2+ BREAST LEPTOMENINGEAL DISEASE (LMD) Open
BACKGROUND IT trastuzumab is used in the management of HER2+ breast LMD. The monoclonal antibody pertuzumab is used with trastuzumab in the management of metastatic and localized HER2+ breast cancer. METHODS The study is a multi-institutio…
View article: Treatment of Central Nervous System Tumors on Combination MR-Linear Accelerators: Review of Current Practice and Future Directions
Treatment of Central Nervous System Tumors on Combination MR-Linear Accelerators: Review of Current Practice and Future Directions Open
Magnetic resonance imaging (MRI) provides excellent visualization of central nervous system (CNS) tumors due to its superior soft tissue contrast. Magnetic resonance-guided radiotherapy (MRgRT) has historically been limited to use in the i…
View article: Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer
Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer Open
Objective Reduced diversity at Human Leukocyte Antigen (HLA) loci may adversely affect the host’s ability to recognize tumor neoantigens and subsequently increase disease burden. We hypothesized that increased heterozygosity at HLA loci is…
View article: Palliative whole brain radiation therapy: an international state of practice
Palliative whole brain radiation therapy: an international state of practice Open
This moment-in-time analysis confirms that patients with poor expected survival are being appropriately selected for WBRT-illustrating the dwindling indications for WBRT-and demonstrates the variance in global practice. Since poor survival…
View article: Rules-based Volumetric Segmentation of Multiparametric MRI for Response Assessment in Recurrent High-Grade Glioma
Rules-based Volumetric Segmentation of Multiparametric MRI for Response Assessment in Recurrent High-Grade Glioma Open
We report domain knowledge-based rules for assigning voxels in brain multiparametric MRI (mpMRI) to distinct tissuetypes based on their appearance on Apparent Diffusion Coefficient of water (ADC) maps, T1-weighted unenhanced and contrast-e…
View article: Characterization of Immune Infiltrates Associated With Radiation Necrosis in the Setting of Brain Metastases Following Stereotactic Radiosurgery and Immunotherapy: A Retrospective Cohort Analysis
Characterization of Immune Infiltrates Associated With Radiation Necrosis in the Setting of Brain Metastases Following Stereotactic Radiosurgery and Immunotherapy: A Retrospective Cohort Analysis Open
The immune microenvironment of brain metastasis following RT and IO showed higher levels of cell infiltrates in the RN setting versus the recurrent tumor setting. Patients who received prior IO compared to those with no IO had similar immu…
View article: Stereotactic radiosurgery and anti-PD-1 + CTLA-4 therapy, anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitors, or conventional chemotherapy for the management of melanoma brain metastases
Stereotactic radiosurgery and anti-PD-1 + CTLA-4 therapy, anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitors, or conventional chemotherapy for the management of melanoma brain metastases Open
View article: A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here
A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here Open
Radiotherapy is an important treatment modality for pain control in patients with bone metastases. Stereotactic body radiation therapy (SBRT), which allows delivering a much higher dose per fraction while sparing critical structures compar…