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View article: Notopterol Attenuates Synovitis via α7nAChR-Dependent Metabolic Reprogramming of Macrophage Polarisation
Notopterol Attenuates Synovitis via α7nAChR-Dependent Metabolic Reprogramming of Macrophage Polarisation Open
View article: CardioRAG: A Retrieval-Augmented Generation Framework for Multimodal Chagas Disease Detection
CardioRAG: A Retrieval-Augmented Generation Framework for Multimodal Chagas Disease Detection Open
Chagas disease affects nearly 6 million people worldwide, with Chagas cardiomyopathy representing its most severe complication. In regions where serological testing capacity is limited, AI-enhanced electrocardiogram (ECG) screening provide…
View article: Implementing an integrated multidisciplinary telehealth platform: a case study at Taichung Veterans General Hospital
Implementing an integrated multidisciplinary telehealth platform: a case study at Taichung Veterans General Hospital Open
Objectives To evaluate the impact of implementing a multidisciplinary integrated telehealth platform in central Taiwan on healthcare accessibility, emergency response and chronic disease management. Methods We analysed data from 26 institu…
View article: Short-Term Oral Microbiota And Metabolome Alterations After Areca Chewing
Short-Term Oral Microbiota And Metabolome Alterations After Areca Chewing Open
Aim or purpose: The oral microbiota is crucial for oral health through metabolic interactions, yet areca nut chewing may disrupt this homeostasis and trigger disease. This study investigates the short-term impacts of areca nut chewing on o…
View article: Impact of surgical modalities on the survival of stage I adult–type ovarian granulosa cell tumor: a comprehensive analysis of 101 cases
Impact of surgical modalities on the survival of stage I adult–type ovarian granulosa cell tumor: a comprehensive analysis of 101 cases Open
Patients with stage I AGCT generally have a favorable prognosis. Surgical extent is an independent prognostic factor. For high risk patients with stage Ic disease or tumor larger than 5 cm, our study supports the selection of radical and o…
View article: Induction and characterization of oral submucous fibrosis model with different pathological stages in rats and mice
Induction and characterization of oral submucous fibrosis model with different pathological stages in rats and mice Open
Oral submucous fibrosis (OSF) is a chronic and progressive fibrosis disease. Although its pathological stages are well characterized in clinical settings, corresponding animal models remain lacking, which has significantly hindered in-dept…
View article: Histological mitotic count is a prognostic marker in vulvar sarcoma: a retrospective case series of 27 patients
Histological mitotic count is a prognostic marker in vulvar sarcoma: a retrospective case series of 27 patients Open
This retrospective study analyzed 27 vulvar sarcoma patients treated at one institution (2005–2024). Mitotic count significantly predicted outcomes: patients with ≥20 mitoses/high power field (HPF) (N = 8) showed drastically worse recurren…
View article: Unveiling the anti-inflammatory potential of RF16, an interleukin 8-derived therapeutic peptide in macrophages
Unveiling the anti-inflammatory potential of RF16, an interleukin 8-derived therapeutic peptide in macrophages Open
View article: Characteristic Impedance Modeling of Nuclear Power Instrumentation and Control Cable Shield Breakage
Characteristic Impedance Modeling of Nuclear Power Instrumentation and Control Cable Shield Breakage Open
Nuclear Instrumentation and Control (I&C) cables laying in a complex environment are prone to shield damage. And, the traveling wave reflection method can be used to detect and locate damage using the characteristic impedance change caused…
View article: Global Insights of Oral Submucous Fibrosis: Concerns About Betel Nut and Oral Cancer
Global Insights of Oral Submucous Fibrosis: Concerns About Betel Nut and Oral Cancer Open
Background Oral submucous fibrosis (OSF) is a chronic progressive fibrosis of oral mucosa, with the possibility of eventually progressing to oral cancer, remaining unclear pathogenesis, and a lack of targeted therapies. This study aims to …
View article: Oral submucous fibrosis: pathogenesis and therapeutic approaches
Oral submucous fibrosis: pathogenesis and therapeutic approaches Open
Oral submucous fibrosis (OSF), characterized by excessive deposition of extracellular matrix (ECM) that causes oral mucosal tissue sclerosis, and even cancer transformation, is a chronic, progressive fibrosis disease. However, despite some…
View article: Study on the Asphalt Pavement Quality Index Evaluation Using a Dual Probability-Enhanced Relative Entropy Information Fusion Method
Study on the Asphalt Pavement Quality Index Evaluation Using a Dual Probability-Enhanced Relative Entropy Information Fusion Method Open
View article: Mitophagy in fibrotic diseases: molecular mechanisms and therapeutic applications
Mitophagy in fibrotic diseases: molecular mechanisms and therapeutic applications Open
Mitophagy is a highly precise process of selective autophagy, primarily aimed at eliminating excess or damaged mitochondria to maintain the stability of both mitochondrial and cellular homeostasis. In recent years, with in-depth research i…
View article: CA-125 elimination rate constant K (KELIM) as a promising predictor of complete cytoreduction after neoadjuvant chemotherapy in advanced ovarian cancer patients: a retrospective study from two Chinese hospitals
CA-125 elimination rate constant K (KELIM) as a promising predictor of complete cytoreduction after neoadjuvant chemotherapy in advanced ovarian cancer patients: a retrospective study from two Chinese hospitals Open
Background The modeled CA-125 elimination constant K (KELIM) is a potential marker of tumor chemosensitivity in ovarian cancer patients treated with neoadjuvant chemotherapy (NACT) before interval surgery. The objective of this study was t…
View article: The role of epithelial cells in fibrosis: Mechanisms and treatment
The role of epithelial cells in fibrosis: Mechanisms and treatment Open
Fibrosis is a pathological process that affects multiple organs and is considered one of the major causes of morbidity and mortality in multiple diseases, resulting in an enormous disease burden. Current studies have focused on fibroblasts…
View article: Preparation of “Needle-Like” Acid-Activated Sepiolite for Enhancing Fluororubber's Mechanical and Heat Resistance Performance
Preparation of “Needle-Like” Acid-Activated Sepiolite for Enhancing Fluororubber's Mechanical and Heat Resistance Performance Open
View article: The causes of intimate partner violence: Attitude-based explanations from the perspective of social learning and feminist theory
The causes of intimate partner violence: Attitude-based explanations from the perspective of social learning and feminist theory Open
View article: EP074/#1447 Clinically early-stage cervical cancer with lymph node metastasis: a study and proposal for revising the 2018 FIGO staging system
EP074/#1447 Clinically early-stage cervical cancer with lymph node metastasis: a study and proposal for revising the 2018 FIGO staging system Open
Introduction To investigate optimal substage of lymph node metastasis in the FIGO staging system for cervical cancer. Methods Patients with early-stage cervical cancer who were surgically confirmed lymph-node metastases between 2008 and 20…
View article: TP004/#1496 Sentinel lymph node biopsy versus pelvic lymphadenectomy in early- stage cervical cancer: a multi-center randomized trial
TP004/#1496 Sentinel lymph node biopsy versus pelvic lymphadenectomy in early- stage cervical cancer: a multi-center randomized trial Open
Introduction Sentinel lymph node (SLN) biopsy has long been considered as an alternative for pelvic lymphadenectomy in cervical cancer. However, the optimal strategy for applying SLN biopsy in cervical cancer remains lacking. Methods We ar…
View article: Highly Enhanced Mechanical, Thermal, and Crystallization Performance of PLA/PBS Composite by Glass Fiber Coupling Agent Modification
Highly Enhanced Mechanical, Thermal, and Crystallization Performance of PLA/PBS Composite by Glass Fiber Coupling Agent Modification Open
To improve the toughness and heat resistance of polylactic acid (PLA), polybutylene succinate (PBS) was sufficiently blended with PLA as the base matrix, and the glass fiber (GF) that was modified with 3-aminopropyltriethoxysilane (KF-GF) …
View article: Data from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Data from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Purpose:Natural killer (NK) cells are type I innate lymphoid cells that are known for their role in killing virally infected cells or cancer cells through direct cytotoxicity. In addition to direct tumor cell killing, NK cells are known to…
View article: Supplementary Figure 5 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 5 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 5 (A) IL-15 amounts in serum of Balb/c mice treated with RT, anti-CD25, anti-asialoGM1 to deplete NK cells, and FLT3L; **** p{less than or equal to}0.0001; n=6. (B) Flow cytometric analysis of DCs MOC2 tumors after tre…
View article: Supplementary Figure 1 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 1 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 1 (A) Flow cytometry analysis of NK cell population expression of NKG2A in MOC2 tumors 3 days after RT; n=3. (B). Flow cytometry analysis of NK cell populations in MOC2 tumors 3 days after RT and anti-NKG2A therapy; n=…
View article: Supplementary Figure 6 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 6 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 6 (A) Survival curve comparing patients with high expression of FLT3, the FLT3LG receptor, to patients with low expression of FLT3 expression. (B) Survival curve comparing patients with high expression of FLT3LG to pat…
View article: Supplementary Figure 1 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 1 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 1 (A) Flow cytometry analysis of NK cell population expression of NKG2A in MOC2 tumors 3 days after RT; n=3. (B). Flow cytometry analysis of NK cell populations in MOC2 tumors 3 days after RT and anti-NKG2A therapy; n=…
View article: Supplementary Figure 3 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 3 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 3 (A) MOC2 tumor volumes of mice treated with RT, anti-CD25, and pLEV vehicle control (black line); RT, anti-CD25, and pLEV FLT3L plasmid (green line), and RT + anti-CD25 (red line). n=7. (B) Flow Cytometry analysis of…
View article: Supplementary Figure 3 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 3 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 3 (A) MOC2 tumor volumes of mice treated with RT, anti-CD25, and pLEV vehicle control (black line); RT, anti-CD25, and pLEV FLT3L plasmid (green line), and RT + anti-CD25 (red line). n=7. (B) Flow Cytometry analysis of…
View article: Supplementary Figure 4 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 4 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 4 (A) Gating strategy used in flow cytometry analysis analyzing NK46+ CD3-NK cells, CD11c+ MHCII+ DCs, CD3+ CD4+ T cells, and CD3+ CD8+ T cells. (B) Flow cytometry analysis of NK cell populations in blood from WT C57BL…
View article: Data from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Data from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Purpose:Natural killer (NK) cells are type I innate lymphoid cells that are known for their role in killing virally infected cells or cancer cells through direct cytotoxicity. In addition to direct tumor cell killing, NK cells are known to…
View article: Supplementary Figure 2 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC
Supplementary Figure 2 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC Open
Supplementary Figure 2 (A) Flow cytometry analysis of LY2 tumors analyzing DC populations; n=6. (B) Analysis of FLT3L present in the serum of LY2 bearing mice treated with radiation therapy and isotype antibodies, radiation therapy and ant…