Yang Yu
YOU?
Author Swipe
View article: Tbl1 promotes Wnt–β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells
Tbl1 promotes Wnt–β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells Open
Activation of the Wnt–β-catenin signaling pathway by CHIR99021, a specific inhibitor of GSK3β, induces Tcf7l1 protein degradation, which facilitates the maintenance of an undifferentiated state in mouse embryonic stem cells (mESCs); howeve…
View article: Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes Open
Background The effects of obesity and diabetes on the clinical outcomes of differentiated thyroid cancer (DTC) remain unclear. Objectives To explore the association between obesity and diabetes with pathological features and therapeutic re…
View article: Epitope identification for p53R273C mutant
Epitope identification for p53R273C mutant Open
Background With the rise of immunotherapy based on cancer neoantigen, identification of neoepitopes has become an urgent problem to be solved. The TP53 R273C mutation is one of the hotspot mutations of TP53, however, the immunogenicity of …
View article: Effects of Ocular Hypertension on Cytoskeleton and Stiffness of Trabecular Meshwork Cells in Rats
Effects of Ocular Hypertension on Cytoskeleton and Stiffness of Trabecular Meshwork Cells in Rats Open
Elevated intraocular pressure (IOP) has been considered to be the major risk factor for glaucoma. The trabecular meshwork (TM), serving as the primary outflow pathway of aqueous humor (AH), has an essential role in controlling IOP. However…
View article: Systematic Studies of the Circadian Clock Genes Impact on Temperature Compensation and Cell Proliferation Using CRISPR Tools
Systematic Studies of the Circadian Clock Genes Impact on Temperature Compensation and Cell Proliferation Using CRISPR Tools Open
Mammalian circadian genes are capable of producing a self-sustained, autonomous oscillation whose period is around 24 h. One of the major characteristics of the circadian clock is temperature compensation. However, the mechanism underlying…
View article: Immunotherapy with a biologically active ICAM-1 mAb and an siRNA targeting TSHR in a BALB/c mouse model of Graves’ disease
Immunotherapy with a biologically active ICAM-1 mAb and an siRNA targeting TSHR in a BALB/c mouse model of Graves’ disease Open
These preliminary data suggest that both the biologically active ICAM-1 mAb and the siRNA targeting TSHR were effective. The ICAM-1 mAb exerted a better therapeutic effect than the siRNA targeting TSHR. Both treatments showed potential eff…
View article: Hypoxia-Inducible Factor-2α Promotes EMT in Esophageal Squamous Cell Carcinoma Through Notch Pathway
Hypoxia-Inducible Factor-2α Promotes EMT in Esophageal Squamous Cell Carcinoma Through Notch Pathway Open
Esophageal squamous cell carcinoma (ESCC) is one of the most common devasting tumor around the world, characterized by persistent hypoxia. Hypoxia-inducible factor-2α (hif-2α) has been regarded as an oncogene in many kinds of cancers, exer…
View article: Identification of the Repressive Domain of the Negative Circadian Clock Component CHRONO
Identification of the Repressive Domain of the Negative Circadian Clock Component CHRONO Open
Circadian rhythm is an endogenous, self-sustainable oscillation that participates in regulating organisms’ physiological activities. Key to this oscillation is a negative feedback by the main clock components Periods and Cryptochromes that…
View article: Identification of the Repressive Domain of the Negative Circadian Clock Component CHRONO
Identification of the Repressive Domain of the Negative Circadian Clock Component CHRONO Open
Circadian rhythm is an endogenous, self-sustainable oscillation that participates in regulating organisms’ physiological activities. Key to this oscillation is a negative feedback by main clock components Periods and Cryptochromes that rep…
View article: Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistance
Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistance Open
Non‑small cell lung carcinomas (NSCLC) are common and are the leading cause of cancer‑associated mortality worldwide. Heptadecanoic acid (C17:0) is an odd‑chain saturated fatty acid. The effect of C17:0 on lung cancer has remained elusive.…
View article: Soybean (Glycine max) prevents the progression of breast cancer cells by downregulating the level of histone demethylase JMJD5
Soybean (Glycine max) prevents the progression of breast cancer cells by downregulating the level of histone demethylase JMJD5 Open
The complicated compositions of soybean will be beneficial to the therapy of breast cancer since its causes may be involved in multiple aspects. Soybean represses breast cancer development by downregulating the level of JMJD5.