Natalie G. Ahn
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View article: Characterization of the Eya and PP2A-B55α interaction
Characterization of the Eya and PP2A-B55α interaction Open
The Eyes Absent (Eya) proteins were first identified as co-activators of the Six homeobox family of transcription factors and are critical in embryonic development. These proteins are also re-expressed in cancers after development is compl…
View article: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2
Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2 Open
Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Author Response: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Author Response: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma Open
The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) whic…
View article: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2
Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2 Open
Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Reviewer #3 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Reviewer #3 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Reviewer #2 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Reviewer #2 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Reviewer #1 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Reviewer #1 (Public Review): Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2 Open
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersio…
View article: Activation loop plasticity and active site coupling in the MAP kinase, ERK2
Activation loop plasticity and active site coupling in the MAP kinase, ERK2 Open
Changes in the dynamics of the protein kinase, ERK2, have been shown to accompany its activation by dual phosphorylation. However, our knowledge about the conformational changes represented by these motions is incomplete. Previous NMR rela…
View article: Molecular insight into the specific interactions of the <scp>SARS‐Coronavirus</scp>‐2 nucleocapsid with <scp>RNA</scp> and host protein
Molecular insight into the specific interactions of the <span>SARS‐Coronavirus</span>‐2 nucleocapsid with <span>RNA</span> and host protein Open
The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) nucleocapsid protein is the most abundantly expressed viral protein during infection where it targets both RNA and host proteins. However, identifying how a single viral prot…
View article: Intermittent treatment of BRAF <sup>V600E</sup> melanoma cells delays resistance by adaptive resensitization to drug rechallenge
Intermittent treatment of BRAF <sup>V600E</sup> melanoma cells delays resistance by adaptive resensitization to drug rechallenge Open
Significance Preclinical studies of metastatic melanoma treated with targeted therapeutics have suggested that alternating periods of treatment and withdrawal might delay the onset of resistance. This has been attributed to drug addiction,…
View article: Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2
Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2 Open
The activation loop segment in protein kinases is a common site for regulatory phosphorylation. In extracellular signal-regulated kinase 2 (ERK2), dual phosphorylation and conformational rearrangement of the activation loop accompany enzym…
View article: Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol <i>O</i> -methyltransferase reaction
Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol <i>O</i> -methyltransferase reaction Open
Human catechol O -methyltransferase (COMT) has emerged as a model for understanding enzyme-catalyzed methyl transfer from S -adenosylmethionine (AdoMet) to small-molecule catecholate acceptors. Mutation of a single residue (tyrosine 68) be…
View article: Proceedings of the Fourth Workshop on Natural Language Processing and Computational Social Science
Proceedings of the Fourth Workshop on Natural Language Processing and Computational Social Science Open
Recognizing the growing community of CSS researchers outside of NLP, as well as new researchers starting out in NLP+CSS, we introduced a new mentoring program that connected volunteers from our Program Committee to authors wanting addition…
View article: Kinase Activation by Small Conformational Changes
Kinase Activation by Small Conformational Changes Open
Protein kinases (PKs) are allosteric enzymes that play an essential role in signal transduction by regulating a variety of key cellular processes. Most PKs suffer conformational rearrangements upon phosphorylation that strongly enhance the…
View article: Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2 Open
Conformational selection by small molecules expands inhibitory possibilities for protein kinases. Nuclear magnetic resonance (NMR) measurements of the mitogen-activated protein (MAP) kinase ERK2 have shown that activation by dual phosphory…
View article: Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2 Open
Modulating the dynamics of protein kinases expands the inhibitory mechanisms for small molecules. NMR measurements of the MAP kinase, ERK2, have shown that activation by dual-phosphorylation induces global motions involving exchange betwee…
View article: Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells
Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells Open
The BRAF-MKK1/2-ERK1/2 pathway is constitutively activated in response to oncogenic mutations of BRAF in many cancer types, including melanoma. Although small molecules that inhibit oncogenic BRAF and MAP kinase kinase (MKK)1/2 have been s…
View article: Structure of histone-based chromatin in Archaea
Structure of histone-based chromatin in Archaea Open
Origin of DNA compaction As a repeating unit in eukaryotic chromatin, a nucleosome wraps DNA in superhelical turns around a histone octamer. Mattiroli et al. present the crystal structure of an archaeal histone-DNA complex in which the his…
View article: Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration
Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration Open
In contrast to events at the cell leading edge, rear-polarized mechanisms that control directional cell migration are poorly defined. Previous work described a new intracellular complex, the Wnt5a-receptor-actomyosin polarity (WRAMP) struc…