Li Yu
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View article: Comparative efficacy of various physical therapies on pain, fatigue, quality of life and functional impairment in breast cancer survivors: a network meta-analysis of randomized controlled trials
Comparative efficacy of various physical therapies on pain, fatigue, quality of life and functional impairment in breast cancer survivors: a network meta-analysis of randomized controlled trials Open
Objective This study aims to conduct a comparative analysis of the effects of different physical therapies on the pain, fatigue, functional impairment, quality of life, and grip strength of breast cancer survivors. Design:A systematic revi…
View article: Pre-classification-learning-based monochromatization strategy for broadband coherent diffraction imaging
Pre-classification-learning-based monochromatization strategy for broadband coherent diffraction imaging Open
Coherent diffraction imaging (CDI) is a lensless imaging technique with significant applications across many fields. It utilizes coherent light to illuminate objects and achieves high-resolution reconstruction from the captured diffraction…
View article: Development and validation of a visual nomogram for predicting clinically significant prostate cancer in negative mpMRI using 68Ga-PSMA PET/CT
Development and validation of a visual nomogram for predicting clinically significant prostate cancer in negative mpMRI using 68Ga-PSMA PET/CT Open
Multi-parametric magnetic resonance imaging (mpMRI) is a valuable medical technology for detecting clinically significant prostate cancer (csPCa). The diagnostic accuracy of mpMRI for csPCa in negative mpMRI (PI-RADS 1-2) remains suboptima…
View article: O-084 Construction of human endometrial complex organoids and their application in endometrial injury repair and regeneration
O-084 Construction of human endometrial complex organoids and their application in endometrial injury repair and regeneration Open
Study question Could human endometrial complex organoid be used to repair endometrial Injury and promote tissue regeneration? Summary answer The complex endometrial organoid we constructed can not only respond to hormonal stimulation but a…
View article: The role of coronary artery calcium scoring in the prediction of coronary artery disease based on non-contrast non-cardiac chest CT scans in airline pilots
The role of coronary artery calcium scoring in the prediction of coronary artery disease based on non-contrast non-cardiac chest CT scans in airline pilots Open
Background The aim of the present study was to explore the value of coronary artery calcium score (CACS) using non-gated, non-contrast chest computed tomography (NCCT) to predict coronary artery disease (CAD) in airline pilots. Methods Pil…
View article: Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome
Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome Open
Purpose Evaluating the biomechanical properties of the aorta is crucial for assessing cardiovascular risk and preventing disease progression. The aim of this study was to evaluate the biomechanical properties of the ascending aorta (AA) in…
View article: Data from Loss of <i>CDKN2A</i> Enhances the Efficacy of Immunotherapy in <i>EGFR</i>-Mutant Non–Small Cell Lung Cancer
Data from Loss of <i>CDKN2A</i> Enhances the Efficacy of Immunotherapy in <i>EGFR</i>-Mutant Non–Small Cell Lung Cancer Open
Mutant EGFR is a common driver of non–small cell lung cancer (NSCLC). Although mutant EGFR has been reported to limit the efficacy of immunotherapy, a subset of patients with EGFR-mutant NSCLC benefit from treatment wi…
View article: Fig. S1 from Loss of <i>CDKN2A</i> Enhances the Efficacy of Immunotherapy in <i>EGFR</i>-Mutant Non–Small Cell Lung Cancer
Fig. S1 from Loss of <i>CDKN2A</i> Enhances the Efficacy of Immunotherapy in <i>EGFR</i>-Mutant Non–Small Cell Lung Cancer Open
Fig. S1 and its figure legend
View article: Fig. S7 from Loss of <i>CDKN2A</i> Enhances the Efficacy of Immunotherapy in <i>EGFR</i>-Mutant Non–Small Cell Lung Cancer
Fig. S7 from Loss of <i>CDKN2A</i> Enhances the Efficacy of Immunotherapy in <i>EGFR</i>-Mutant Non–Small Cell Lung Cancer Open
Fig. S7 and its figure legend
View article: The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study
The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study Open
Background Chronic low-grade inflammation is recognized as a significant factor in various health outcomes, including the development and progression of breast cancer. The Systemic Immune-Inflammation Index (SII), a novel marker derived fr…
View article: Multimodal ultrasound assessment of myocardial perfusion and contractile function in patients with hypertrophic cardiomyopathy and their first-degree relatives.
Multimodal ultrasound assessment of myocardial perfusion and contractile function in patients with hypertrophic cardiomyopathy and their first-degree relatives. Open
Myocardial contractile dysfunction in HCM patients is closely related to impaired perfusion. Even in the absence of wall hypertrophy, sarcomere mutation carriers show early signs of subclinical left ventricular dysfunction. MCE and VVI can…
View article: Association between Neutrophil-to-high-density lipoprotein-cholesterol ratio and gallstones: insights from the national health and nutrition examination survey (2017–2020)
Association between Neutrophil-to-high-density lipoprotein-cholesterol ratio and gallstones: insights from the national health and nutrition examination survey (2017–2020) Open
View article: Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating <i>SREBP‐1c</i> Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism
Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating <i>SREBP‐1c</i> Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism Open
Glycerol kinase (GK) participates in triglyceride (TG) synthesis by catalyzing glycerol metabolism. Whether GK contributes to nonalcoholic fatty liver (NAFL) is unclear. The expression of hepatic Gk is found to be increased in diet‐induced…
View article: <b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b>
<b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b> Open
AbstractOvernutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD pro…
View article: <b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b>
<b>Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease</b> Open
AbstractOvernutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD pro…
View article: Deep learning-based vessel extraction in 3D confocal microscope images of cleared human glioma tissues
Deep learning-based vessel extraction in 3D confocal microscope images of cleared human glioma tissues Open
Comprehensive visualization and accurate extraction of tumor vasculature are essential to study the nature of glioma. Nowadays, tissue clearing technology enables 3D visualization of human glioma vasculature at micron resolution, but curre…
View article: MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10 Open
View article: Establishment and validation of a polygene prognostic model for clear cell renal cell carcinoma
Establishment and validation of a polygene prognostic model for clear cell renal cell carcinoma Open
Purpose: To establish an effective prognostic model for patients with clear cell renal cell carcinoma (ccRCC). Methods: We identified four hub differentially expressed genes (DEGs) in Gene Expression Omnibus (GEO) database and verified the…
View article: SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration
SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration Open
Our understanding of full-thickness endometrial regeneration after injury is limited by an incomplete molecular characterization of the cell populations responsible for the organ functions. To help fill this knowledge gap, we characterized…
View article: Murine Chronic Pancreatitis Model Induced by Partial Ligation of the Pancreatic Duct Encapsulates the Profile of Macrophage in Human Chronic Pancreatitis
Murine Chronic Pancreatitis Model Induced by Partial Ligation of the Pancreatic Duct Encapsulates the Profile of Macrophage in Human Chronic Pancreatitis Open
Immune responses are an integral part of the pathogenesis of pancreatitis. Studies applying the mouse model of pancreatitis induced by partial ligation of the pancreatic duct to explore the pancreatic immune microenvironment are still lack…
View article: A Concomitant Cancer Diagnosis Is Associated With Poor Cardiovascular Outcomes Among Acute Myocardial Infarction Patients
A Concomitant Cancer Diagnosis Is Associated With Poor Cardiovascular Outcomes Among Acute Myocardial Infarction Patients Open
Background and Aims With the increasing coexistence of cardiovascular disease and cancer in contemporary clinical practice, studies on the outcomes in acute myocardial infarction (AMI) patients with cancer has not been systematically inves…
View article: Characterization of diagnostic and prognostic significance of cell cycle-linked genes in hepatocellular carcinoma
Characterization of diagnostic and prognostic significance of cell cycle-linked genes in hepatocellular carcinoma Open
We created a prediction model using six cell cycle-linked genes to predict HCC prognosis. The six genes are expected to be novel markers for HCC diagnosis, as well as treatment.
View article: A hypoxia-linked gene signature for prognosis prediction and evaluating the immune microenvironment in patients with hepatocellular carcinoma
A hypoxia-linked gene signature for prognosis prediction and evaluating the immune microenvironment in patients with hepatocellular carcinoma Open
A prediction model for predicting HCC prognosis using six hypoxia-linked genes was designed in this study, facilitating the diagnosis and treatment of HCC.
View article: In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK)
In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK) Open
Background Entrectinib is a CNS-active, potent inhibitor of tyrosine receptor kinases A/B/C, ROS1 and anaplastic lymphoma kinase approved for use in patients with solid tumors. We describe the in vitro and clinical studies investigating po…
View article: Peer Review #2 of "Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide (v0.1)"
Peer Review #2 of "Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide (v0.1)" Open
Background and Aims.Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes.The main purpose of this study is to explore the changes of circulating Fetuin-B in young wome n w…
View article: Peer Review #1 of "Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide (v0.2)"
Peer Review #1 of "Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide (v0.2)" Open
Background and Aims.Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes.The main purpose of this study is to explore the changes of circulating Fetuin-B in young wome n w…
View article: Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide Open
Background and Aims Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women w…
View article: Peer Review #1 of "Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide (v0.1)"
Peer Review #1 of "Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide (v0.1)" Open
Background and Aims.Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes.The main purpose of this study is to explore the changes of circulating Fetuin-B in young wome n w…
View article: Velocity vector imaging echocardiography and N- terminal pro- brain natriuretic peptide study of people with preclinical hypertrophic cardiomyopathy
Velocity vector imaging echocardiography and N- terminal pro- brain natriuretic peptide study of people with preclinical hypertrophic cardiomyopathy Open
Background: To investigate whether familial hypertrophic cardiomyopathy (HCM) gene mutation carriers without overt left ventricular hypertrophy have subclinical changes in left ventricular function.Methods: We studied Eighteen HCM families…
View article: Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors
Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors Open
Summary Background : Entrectinib is an oral, CNS-active, potent inhibitor of tyrosine receptor kinases A/B/C, tyrosine kinase ROS proto-oncogene 1, and anaplastic lymphoma kinase approved for use in patients with solid tumors. We describe …