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Pyramidal soma size in the anterior cingulate cortex is small in schizophrenia and correlates with hallucination score Open

Ryuta Mizutani, Rino Saiga, Yoshiro Yamamoto, Chie Inomoto, Hiroshi Kajiwara , et al. · 2025

Volumetric reduction of gray matter has repeatedly been reported for schizophrenia. Although meta-analyses of imaging studies revealed the macroscopic reduction of the anterior cingulate cortex in schizophrenia, its mechanism at the cellul…

Imaging changes of pulmonary thromboembolism on postmortem computed tomography Open

Motoo Yoshimiya, Takahiro Ueda, Ikuto Takeuchi, Atsushi Ueda, Yu Kakimoto · 2025

To our knowledge, this is the first report to demonstrate time-dependent imaging evolution of pulmonary thromboemboli using serial non-contrast PMCT. Recognition of such temporal imaging alterations may enhance the diagnostic utility of PM…

Avoiding Missed Diagnoses of Pharyngeal Foreign Bodies in Postmortem Investigations: A Case Report of Denture-Related Asphyxia Open

Ikuto Takeuchi, Motoo Yoshimiya, Atsushi Ueda, Yu Kakimoto · 2025

Foreign body asphyxia due to pharyngeal denture impaction is an uncommon but potentially fatal event, especially in elderly individuals. This report describes a forensic case in which an acrylic resin denture was discovered impacted in the…

Postmortem diagnosis of fatal venous air embolism due to sigmoid sinus rupture associated with a basilar skull fracture Open

Motoo Yoshimiya, Ikuto Takeuchi, Atsushi Ueda, Yu Kakimoto · 2025

We report a fatal case of VAE caused by air entry through a basilar skull fracture with confirmed rupture of the right sigmoid sinus. This condition may be overlooked without PMCT. Vigilance is essential in severe head trauma cases.

Extension-Type Spinal Fractures on Flat Surfaces: Forensic Autopsy Findings From Two Cases Open

Ikuto Takeuchi, Motoo Yoshimiya, Atsushi Ueda, Yu Kakimoto · 2025

Facial Barotrauma Mimicking Trauma: A Forensic Case of Mask Squeeze in a Diving Fatality Open

Ikuto Takeuchi, Motoo Yoshimiya, Atsushi Ueda, Yu Kakimoto · 2025

Periorbital ecchymosis - commonly known as "raccoon eyes" - is a classical indicator of traumatic head injury, particularly basilar skull fractures. However, similar findings may also arise from non-traumatic causes, including systemic dis…

Postmortem Lividity Color Change During Rewarming Following Cold Storage: A Case Report of Drowning Open

Ikuto Takeuchi, Haruka Ikeda, Motoo Yoshimiya, Atsushi Ueda, Yu Kakimoto · 2025

Discrepant Bleeding Patterns in a Case of Simultaneous Injuries: Hemodynamic Consequences of Bilateral Carotid Artery Transection Open

Ikuto Takeuchi, Motoo Yoshimiya, Atsushi Ueda, Yu Kakimoto · 2025

Structural differences between human and mouse neurons and their implementation in generative AIs Open

Rino Saiga, Kiyoto Shiga, Yasuhiro Maruta, Chie Inomoto, Hiroshi Kajiwara , et al. · 2025

Circular Skin Lesions Mimicking Blunt Trauma: A Forensic Case of Cupping Therapy Open

Ikuto Takeuchi, Motoo Yoshimiya, Atsushi Ueda, Yu Kakimoto · 2025

Murine AI excels at cats and cheese: Structural differences between human and mouse neurons and their implementation in generative AIs Open

Rino Saiga, Kiyoto Shiga, Yasuhiro Maruta, Chie Inomoto, Hiroshi Kajiwara , et al. · 2024

Mouse and human brains have different functions that depend on their neuronal networks. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the mouse medial prefrontal cortex and compared them with s…

Wieacker–Wolff syndrome with hyperinsulinemic hypoglycemia successfully treated using diazoxide: A case report Open

Satoko Kobayashi, Ayami Sato, Yumiko Chiba, Natsuho Adachi, Yu Kakimoto , et al. · 2024

Wieacker-Wolff syndrome (WRWF) is an X-linked genetic disorder characterized by neuromusculoskeletal abnormalities caused by loss-of-function variants of the ZC4H2 gene. Here, we report the case of a male infant with WRWF manifestin…

Layer-specific proteomic profiling of human normal heart Open

Yu Kakimoto, Atsushi Ueda, Yayoi Kimura, Tomoko Akiyama, Masayuki Tanaka , et al. · 2024

This is the first report on layer-specific proteomic profiling of human normal hearts. Anisotropic profiles of actin filament-binding proteins in myocardial layers may contribute to the anisotropic contractile and conductive abilities of t…

Forensic Characteristics of Body Abandonment by Housemates in Japan Open

Haruaki Naito, Yasuhiro Kakiuchi, Yu Kakimoto, Motoki Osawa · 2024

Assessment of maxillary sinus fluid volume for postmortem diagnosis of drowning Open

Yu Kakimoto, Shigeo Ohno, Takuya Saito, Shotaro Isozaki, H. Ikeda , et al. · 2023

Fluid accumulation in both the maxillary sinuses strongly predicts drowning in the postmortem imaging.

Unexpected sudden death on arrival in a healthy middle-aged man associated with COVID-19-related diffuse cardiac injury: A case report Open

Shotaro Isozaki, Yu Kakimoto, Haruka Ikeda, Yutaka Matsushima, Akio Tsuboi , et al. · 2023

Intraventricular Cerliponase Alfa Treatment in a Patient with Advanced Neuronal Ceroid Lipofuscinosis Type 2 Open

Saki Nakashima, Masashi Hamada, Tomohiko Kimura, Shuichi Tanifuji, Akiko Takahashi , et al. · 2023

Neuronal ceroid lipofuscinosis type 2 (CLN2) is an autosomal recessive lysosomal disease caused by decreased activity of the enzyme tripeptidyl peptidase 1 (TPP1) due to pathogenic variants in the TPP1 gene. Cerliponase alfa, a recombinant…

Proteomic profiling of sudden cardiac death with acquired cardiac hypertrophy Open

Yu Kakimoto, Atsushi Ueda, Masatoshi Ito, Masayuki Tanaka, Tomoko Kubota , et al. · 2023

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system Open

Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka , et al. · 2023

Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled inositol pyrophosphate levels in mammalian organs u…

Correlation of cytomegalovirus viral load between whole blood and plasma of congenital cytomegalovirus infection under valganciclovir treatment Open

Yuka Torii, Ichiro Morioka, Yasumasa Kakei, Kazumichi Fujioka, Yu Kakimoto , et al. · 2023

Association of decomposition in the hands and feet with postmortem submersion interval in the sea Open

K Oshiro, Takuya Saito, Kosuke Owada, Haruaki Naito, Yutaka Matsushima , et al. · 2023

This article aims to evaluate estimation of the postmortem submersion interval (PMSI) for cadavers recovered from the Pacific Ocean in the South Kanto area of Japan. Data were collected from crime scene reports in the 3rd Regional Coast Gu…

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP<sub>7</sub> metabolism in enteric nervous system Open

Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka , et al. · 2022

Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled PP-IP levels in mammalian organs using a n…

Gastric aspiration in sudden unexpected infant death of Prader–Willi syndrome: immunohistochemical detection of feeding components Open

Motoki Osawa, Haruka Ikeda, Atsushi Ueda, Haruaki Naito, Ryoko Nagao , et al. · 2022

Non-polyalanine repeat mutation in PHOX2B is detected in autopsy cases of sudden unexpected infant death Open

Atsushi Ueda, Motoki Osawa, Haruaki Naito, Eriko Ochiai, Yu Kakimoto · 2022

Background Congenital central hypoventilation syndrome (CCHS), which is caused by PHOX2B with phenotypic variations, has a point of controversy: CCHS is putatively involved in autopsy cases of sudden unexpected infant death (SUID) includin…

Nonocclusive mesenteric ischemia secondary to spinal cord injury: an autopsy case Open

Yu Kakimoto, Yutaka Matsushima, Akio Tsuboi, Yoshihisa Seto, Motoki Osawa · 2021

Cutoff value for hypertrophic heart weight in the Japanese population Open

Yu Kakimoto, Kumiko Asakura, Motoki Osawa · 2020

Thus, the criteria for hypertrophic heart weight are practical and useful for autopsy recordings, and it can be helpful for postmortem diagnosis of CVD. Our report is the first to reveal the cutoff value for hypertrophic heart weight in th…

Circumstances and factors of sleep-related sudden infancy deaths in Japan Open

Motoki Osawa, Yasuhiro Ueno, Noriaki Ikeda, Kazuya Ikematsu, Takuma Yamamoto , et al. · 2020

This study confirmed the trends that have been observed for sudden infant death syndrome; particularly, very high odds ratios were evident for teenage mothers and later birth order in comparison with those in other developed countries. Neg…

Circumstances and factors of sleep-related sudden infancy deaths in Japan Open

Motoki Osawa, Yasuhiro Ueno, Noriaki Ikeda, Kazuya Ikematsu, Takuma Yamamoto , et al. · 2020

Background Sudden unexpected death in infancy (SUDI) comprises both natural and unnatural causes of death. However, a few epidemiological surveys have investigated SUDI in Japan. Objective This retrospective study was conducted to investig…

Hierarchical Cluster and Region of Interest Analyses Based on Mass Spectrometry Imaging of Human Brain Tumours Open

Takuya Hiratsuka, Yoshiki Arakawa, Yuka Yajima, Yu Kakimoto, Keisuke Shima , et al. · 2020

Imaging mass spectrometry (IMS) has been rarely used to examine specimens of human brain tumours. In the current study, high quality brain tumour samples were selected by tissue observation. Further, IMS analysis was combined with a new hi…

Myocardial cathepsin D is downregulated in sudden cardiac death Open

Yu Kakimoto, Ayumi Sasaki, Maki Niioka, Noboru Kawabe, Motoki Osawa · 2020

Cathepsins are the major lysosomal proteases that maintain intracellular homeostasis. Herein, we investigated the alterations in myocardial cathepsin expression during aging, cardiac hypertrophy, and sudden cardiac death (SCD). Cardiac tis…

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