Yu Koyanagi
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View article: Chronic Pulmonary Aspergillosis Masquerading as a Tumor-like Mass with a Stone-paved Appearance
Chronic Pulmonary Aspergillosis Masquerading as a Tumor-like Mass with a Stone-paved Appearance Open
View article: Dennd2c Negatively Controls Multinucleation and Differentiation in Osteoclasts by Regulating Actin Polymerization and Protrusion Formation
Dennd2c Negatively Controls Multinucleation and Differentiation in Osteoclasts by Regulating Actin Polymerization and Protrusion Formation Open
Osteoclasts are bone-resorbing multinucleated giant cells formed by the fusion of monocyte/macrophage lineages. Various small GTPases are involved in the multinucleation and differentiation of osteoclasts. However, the roles of small GTPas…
View article: Autophagy Regulator Rufy 4 Promotes Osteoclastic Bone Resorption by Orchestrating Cytoskeletal Organization via Its RUN Domain
Autophagy Regulator Rufy 4 Promotes Osteoclastic Bone Resorption by Orchestrating Cytoskeletal Organization via Its RUN Domain Open
Rufy4, a protein belonging to the RUN and FYVE domain-containing protein family, participates in various cellular processes such as autophagy and intracellular trafficking. However, its role in osteoclast-mediated bone resorption remains u…
View article: Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury
Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury Open
We aimed to clarify the functional roles of CD26/DPP4 in ARDS pathophysiology using Dpp4-deficient mice and siRNA reduction techniques in cultured lung cells. Our results suggest that CD26/DPP4 expression plays a proinflammatory role in al…
View article: Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease
Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease Open
Pulmonary hypertension (PH) with interstitial lung diseases (ILDs) often causes intractable conditions. CD26/Dipeptidyl peptidase-4 (DPP4) is expressed in lung constituent cells and may be related to the pathogenesis of various respiratory…
View article: Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase
Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase Open
Background: Osteoclasts are multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage lineage. During osteoclast differentiation, Rho GTPases are involved in various processes, including cell migration, adhesion, and …
View article: Functional roles of <scp>CD26</scp>/<scp>DPP4</scp> in bleomycin‐induced pulmonary fibrosis
Functional roles of <span>CD26</span>/<span>DPP4</span> in bleomycin‐induced pulmonary fibrosis Open
The pathogenesis of pulmonary fibrosis involves complex interplay between cell types and signaling pathways. Recurrent alveolar epithelial injury can occur during pulmonary inflammation, causing dysregulation of epithelial repair. Dysregul…
View article: P2‐5: TGF‐Β‐induced epithelial‐mesenchymal transition and tumor‐promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma
P2‐5: TGF‐Β‐induced epithelial‐mesenchymal transition and tumor‐promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma Open
endothelial growth factor receptor (VEGFR)-3 and integrin α9 were elevated in LAM-LECs.Inhibition of VEGFR-3 suppressed proliferation and migration of LECs, and blockade of integrin α9 reduced VEGF-D-induced migration of LECs.Conclusions: …
View article: LPS-Induced Lung Injury Is Attenuated in CD26/DPP4 Deficient Mice
LPS-Induced Lung Injury Is Attenuated in CD26/DPP4 Deficient Mice Open
View article: Anti-PL-7 Antisynthetase Syndrome with Eosinophilic Pleural Effusion
Anti-PL-7 Antisynthetase Syndrome with Eosinophilic Pleural Effusion Open
A 68-year-old woman was admitted to our hospital with fever and pleural effusion. Her thoracentesis showed eosinophilic pleural effusion (EPE) without any evidence of malignancy, infection, or trauma. Pleural biopsy revealed pleuritis and …
View article: IgG4-related disease presenting with combined pulmonary fibrosis and emphysema (CPFE)
IgG4-related disease presenting with combined pulmonary fibrosis and emphysema (CPFE) Open