Lei Yu
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View article: Machine learning-enhanced confocal Raman imaging enables label-free diagnosis and spatial metabolic profiling of isoniazid-induced hepatotoxicity
Machine learning-enhanced confocal Raman imaging enables label-free diagnosis and spatial metabolic profiling of isoniazid-induced hepatotoxicity Open
Rationale: Isoniazid-induced liver injury (INH-ILI) poses a significant clinical challenge due to the lack of reliable, non-invasive, and real-time diagnostic tools. Here, we present an integrated platform that combines label-free c…
View article: Dominant and cross-reactive S1-specific memory B cell response induced by primary SARS-CoV-2 infection
Dominant and cross-reactive S1-specific memory B cell response induced by primary SARS-CoV-2 infection Open
The protective component of specific memory B cells (MBCs) response relative to serum antibody response in primary SARS-CoV-2 infection is not well understood. Using a relatively unbiased B-cell culture method with a limited number of MBCs…
View article: Uncovering the <i>Nanozostera japonica</i> species complex suggests cryptic speciation and underestimated seagrass diversity
Uncovering the <i>Nanozostera japonica</i> species complex suggests cryptic speciation and underestimated seagrass diversity Open
Summary The importance of marine angiosperms, or seagrasses, as foundation species for marine coastal ecosystems is in marked contrast to their low species number of only 70 described taxa. Seagrass species tend to have very similar overal…
View article: Screening and evaluation of rice germplasm resources with low nitrogen tolerance
Screening and evaluation of rice germplasm resources with low nitrogen tolerance Open
View article: A somatic genetic clock for clonal species
A somatic genetic clock for clonal species Open
View article: Rapid Nucleic Acid Diagnostic Technology for Pandemic Diseases
Rapid Nucleic Acid Diagnostic Technology for Pandemic Diseases Open
The recent global pandemic of coronavirus disease 2019 (COVID-19) has enormously promoted the development of diagnostic technology. To control the spread of pandemic diseases and achieve rapid screening of the population, ensuring that pat…
View article: Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide-Induced Oxidative Stress in Corynebacterium Glutamicum
Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide-Induced Oxidative Stress in Corynebacterium Glutamicum Open
View article: The Environmental Risk Threshold (Hc5) for Cd Remediation in Chinese Agricultural Soils
The Environmental Risk Threshold (Hc5) for Cd Remediation in Chinese Agricultural Soils Open
View article: Precise age estimation in clonal species using a somatic genetic clock
Precise age estimation in clonal species using a somatic genetic clock Open
Age and longevity are key parameters for demography and life-history evolution of organisms. In clonal species, a widespread life history among animals, plants, algae and fungi, the sexually produced offspring (the genet) grows indetermina…
View article: An evolutionary epigenetic clock in plants
An evolutionary epigenetic clock in plants Open
Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~10 5 to 10 8 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past. Here, we demonstrate…
View article: Author Correction: Ocean current patterns drive the worldwide colonization of eelgrass (Zostera marina)
Author Correction: Ocean current patterns drive the worldwide colonization of eelgrass (Zostera marina) Open
View article: Ocean current patterns drive the worldwide colonization of eelgrass (Zostera marina)
Ocean current patterns drive the worldwide colonization of eelgrass (Zostera marina) Open
View article: Engineering of the DNA replication and repair machinery to develop binary mutators for rapid genome evolution of <i>Corynebacterium glutamicum</i>
Engineering of the DNA replication and repair machinery to develop binary mutators for rapid genome evolution of <i>Corynebacterium glutamicum</i> Open
Corynebacterium glutamicum is an important industrial workhorse for production of amino acids and chemicals. Although recently developed genome editing technologies have advanced the rational genetic engineering of C. glutamicum, continuou…
View article: Environmental Risk Threshold for Cd in Chinese Soils
Environmental Risk Threshold for Cd in Chinese Soils Open
View article: Response of leaf biomass, leaf and soil C:N:P stoichiometry characteristics to different site conditions and forest ages: a case of Pinus tabuliformis plantations in the temperate mountainous area of China
Response of leaf biomass, leaf and soil C:N:P stoichiometry characteristics to different site conditions and forest ages: a case of Pinus tabuliformis plantations in the temperate mountainous area of China Open
Ecological stoichiometry is an important index that reflects the element cycle and ecosystem stability. In this study, two sites (sunny and shady slopes) and five forest ages (young stage, half-mature stage, near-mature stage, mature stage…
View article: Ocean currents drive the worldwide colonization of the most widespread marine plant, eelgrass (<i>Zostera marina</i>)
Ocean currents drive the worldwide colonization of the most widespread marine plant, eelgrass (<i>Zostera marina</i>) Open
Currents are unique drivers of oceanic phylogeography and so determine the distribution of marine coastal species, along with past glaciations and sea level changes. Here, we reconstruct the worldwide colonization history of eelgrass ( Zos…
View article: Detecting clonemate pairs in multicellular diploid clonal species based on a shared heterozygosity index
Detecting clonemate pairs in multicellular diploid clonal species based on a shared heterozygosity index Open
Clonal reproduction, the formation of nearly identical individuals via mitosis in the absence of genetic recombination, is a very common reproductive mode across plants, fungi and animals. To detect clonal genetic structure, genetic simila…
View article: Combined influence of low temperature and drought on different varieties of rapeseed (Brassica napus L.)
Combined influence of low temperature and drought on different varieties of rapeseed (Brassica napus L.) Open
In recent years, due to the change of farming system, delayed the sowing time of rapeseed, and low temperature and drought would affect the sowing quality, seedling growth, and rapeseed yield.Thirty-one rapeseed materials were screened for…
View article: Genetic diversity, population structure and core collection analysis of Hunan tea plant germplasm through genotyping-by-sequencing
Genetic diversity, population structure and core collection analysis of Hunan tea plant germplasm through genotyping-by-sequencing Open
Tea is considered to be a well-known and widely consumed beverage and Hunan province is rich in tea plant germplasm. In order to better conserve and utilize Hunan tea plant resources, 110 tea accessions from seven geographical origins were…
View article: Ecological Toxicity (Ecx) of Pb and its Prediction Models in Chinese Soils with Various Properties
Ecological Toxicity (Ecx) of Pb and its Prediction Models in Chinese Soils with Various Properties Open
View article: Effects of microscopic testa color and morphologyon the water uptake ability and drought tolerance of germination-stage rapeseed (<i>Brassica napus</i> L.)
Effects of microscopic testa color and morphologyon the water uptake ability and drought tolerance of germination-stage rapeseed (<i>Brassica napus</i> L.) Open
Drought is one of the most important abiotic stressors that affect crop yield. Therefore, the aim of the present study was to investigate correlations between germination-stage drought tolerance and the microscopic testa (i.e., seed coat) …
View article: Genetic Diversity and Molecular Characterization of Worldwide Prairie Grass (Bromus catharticus Vahl) Accessions Using SRAP Markers
Genetic Diversity and Molecular Characterization of Worldwide Prairie Grass (Bromus catharticus Vahl) Accessions Using SRAP Markers Open
Prairie grass (Bromus catharticus Vahl) is an important grass species that could be used in the production systems of certified seed and high-quality forage for grazing ruminants. In the present research, a sequence-related amplified polym…
View article: How C: N: P stoichiometry in soils and carbon distribution in plants respond to forest age in a <i>Pinus tabuliformis</i> plantation in the mountainous area of eastern Liaoning Province, China
How C: N: P stoichiometry in soils and carbon distribution in plants respond to forest age in a <i>Pinus tabuliformis</i> plantation in the mountainous area of eastern Liaoning Province, China Open
Carbon distribution in plants and ecological stoichiometry in soils are important indicators of element cycling and ecosystem stability. In this study, five forest ages, young forest (YF), middle-aged forest (MAF), near-mature forest (NMF)…
View article: Response of Leaf Biomass, Leaf and Soil C:N:P Stoichiometry Characteristics to Different Site Conditions and Forest Age: A Case of Pinus Tabuliformis Plantations in the Temperate Mountainous Area of China
Response of Leaf Biomass, Leaf and Soil C:N:P Stoichiometry Characteristics to Different Site Conditions and Forest Age: A Case of Pinus Tabuliformis Plantations in the Temperate Mountainous Area of China Open
Background: Ecological stoichiometry is an important index that reflects the element cycle and ecosystem stability. In this study, two sites (sunny and shady slopes) and five forest ages (young forest, middle-aged forest, near-mature fores…
View article: Which species does the virus like most: Binding modes study between SARS-CoV-2 S protein and ACE2 receptor
Which species does the virus like most: Binding modes study between SARS-CoV-2 S protein and ACE2 receptor Open
View article: Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation Open
View article: Somatic genetic drift and multilevel selection in a clonal seagrass
Somatic genetic drift and multilevel selection in a clonal seagrass Open
View article: Somatic genetic drift and multi-level selection in modular species
Somatic genetic drift and multi-level selection in modular species Open
Cells in multicellular organisms are genetically heterogeneous owing to somatic mutations. The accumulation of somatic genetic variation in species undergoing asexual (or clonal) reproduction (termed modular species) may lead to phenotypic…
View article: Latent Infection of Powdery Mildew on Volunteer Wheat in Sichuan Province, China
Latent Infection of Powdery Mildew on Volunteer Wheat in Sichuan Province, China Open
Wheat powdery mildew, caused by the fungal pathogen Blumeria graminis f. sp. tritici, is one of the most destructive wheat diseases in China, especially in Sichuan Province. Successfully oversummered B. graminis f. sp. tritici can become a…
View article: Microbial Diversity of Rhizosphere Soil of Tobacco at Different Growth Periods
Microbial Diversity of Rhizosphere Soil of Tobacco at Different Growth Periods Open
This paper aims to analyze microbial diversity of tobacco rhizosphere soil at different growth stages.With tobacco rhizosphere soil as the research object, high throughout sequencing was carried out on DNA of 16S rDNA-V4 region and fungi o…