Explanipedia

Correction: FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway Open

Yiming Li, Jianshen Liang, Xiude Ren, Jiahe Guo, Xisen Wang , et al. · 2025

[This corrects the article DOI: 10.3389/fonc.2025.1560008.].

Interrogation of macrophage-related prognostic signatures reveals a potential immune-mediated therapy strategy by histone deacetylase inhibition in glioma Open

Xisen Wang, Xuya Wang, Lei Chen, Hao Ding, Jikang Fan , et al. · 2025

Background Glioma-associated macrophages (GAMs) originate from intracranially resident microglia and myeloid-derived macrophages. In the glioma microenvironment, these two types of macrophages tend to adopt a specialized activation state k…

Case Report: The price of intraoperative cell salvage? - implantation metastases of meningioma in both lungs and left cubital fossa Open

Mengyao He, Shengping Yu, Wenjun Luo, Zhang Yu, Wenchao Liu , et al. · 2025

Meningiomas are common Central Nervous System (CNS) tumors, typically benign, but they can occasionally metastasize or exhibit aggressive behavior. We present a case of meningioma with metastasis to unique sites (pulmonary and left cubital…

FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway Open

Yiming Li, Jianshen Liang, Xiude Ren, Jiahe Guo, Xisen Wang , et al. · 2025

Objective The Fibroblast growth factor receptors 3-transforming acidic coiled-coil-containing protein 3 (FGFR3-TACC3, F3-T3) oncogenic fusion gene, identified in malignant tumors such as gliomas and bladder cancer, has been particularly no…

GPR65 contributes to constructing immunosuppressive microenvironment in glioma Open

Jikang Fan, Jie Liu, Bin Zhang, Xuya Wang, Xisen Wang , et al. · 2024

NCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway Open

Jianshen Liang, Debo Yun, Wen-Zhe Jin, Jikang Fan, Xuya Wang , et al. · 2024

Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function of NCAPH in gliomas is still …

Correction: TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas Open

Jiabo Li, Xuya Wang, Lulu Chen, Jinhao Zhang, Yiming Zhang , et al. · 2024

Following the publication of this article, reuse of an image was noted in Figures 3J and3N depicting the migration and invasion of the sh-TMEM158-1 treated group in the U251MG cell line.Upon reviewing these figures alongside the original d…

TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling Open

Debo Yun, Jianshen Liang, Xuya Wang, Jikang Fan, Xisen Wang , et al. · 2023

Diffusion tensor imaging versus intraoperative subcortical mapping for glioma resection: a systematic review and meta-analysis Open

Yiming Li, Jiahe Guo, Kai Zhang, Huijie Wei, Jikang Fan , et al. · 2023

Maintaining the integrity of crucial fiber tracts allows functional preservation and improved recovery in patients with glioma resection. Diffusion tensor imaging (DTI) and intraoperative subcortical mapping (ISM) are commonly required for…

PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma Open

Xuya Wang, Xisen Wang, Jiabo Li, Jianshen Liang, Xiao Ren , et al. · 2022

A Novel Prognostic Signature Based on Glioma Essential Ferroptosis-Related Genes Predicts Clinical Outcomes and Indicates Treatment in Glioma Open

Debo Yun, Xuya Wang, Wenbo Wang, Xiao Ren, Jiabo Li , et al. · 2022

Background Ferroptosis is a form of programmed cell death (PCD) that has been implicated in cancer progression, although the specific mechanism is not known. Here, we used the latest DepMap release CRISPR data to identify the essential fer…

Calcium-Related Gene Signatures May Predict Prognosis and Level of Immunosuppression in Gliomas Open

Peidong Liu, Yu Li, Yiming Zhang, John Choi, Jinhao Zhang , et al. · 2022

Gliomas are the most common primary brain cancer. While it has been known that calcium-related genes correlate with gliomagenesis, the relationship between calcium-related genes and glioma prognosis remains unclear. We assessed TCGA datase…

Advanced modalities and surgical theories in glioma resection Open

Jiahe Guo, Yiming Li, Kai Zhang, Jiabo Li, Jiabo Li , et al. · 2022

Surgical resection is the core of the comprehensive treatment of glioma. However, with infiltrative growth features, glioma often invades the surrounding area, making surgical resection more difficult. This review introduces relevant topic…

Reconstruction clipping of ruptured anterior circulation aneurysms via supraorbital lateral keyhole approach Open

Yuzhang Wu, Yan Zhao, Shengping Yu, Fan Li, Shifei Cai , et al. · 2022

Background Intracranial aneurysm (IA) is a serious disease. Analyze and review the cases of anterior circulation ruptured IA by supraorbital lateral keyhole approach, and summarize the experiences of this approach. Methods Retrospective an…

TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas Open

Jiabo Li, Xuya Wang, Lulu Chen, Jinhao Zhang, Yiming Zhang , et al. · 2022

Transcription Factor Signatures May Predict the Prognosis and Status of the Immune Microenvironment of Primary Lower-Grade Gliomas Open

Peidong Liu, Ruojie Wu, Jinhao Zhang, Yiming Zhang, Chen Zhang , et al. · 2021

Our findings suggested that the 6-TFs model could be used to predict prognosis and predict the status of the immune microenvironment in LGG.

The surgical resection of dysplastic cerebellar gangliocytoma assisted by intraoperative sonography: illustrative case Open

Yiming Li, Jiahe Guo, Huijie Wei, Cuiyun Sun, Yan Chai , et al. · 2021

BACKGROUND Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) is an extremely rare, slow-growing hereditary mass lesion that is mainly characterized by both specific neuroradiological features and secondary hydrocephalus…

Summary of each WHO Classification of Tumors of the Central Nervous System prior to the fifth edition Open

Shengping Yu, Haolang Ming, Bingcheng Ren, Lin Yu, Zhang Chen , et al. · 2021

WHO Classification of Tumors of the Central Nervous System (CNS) has been developed in the past more than 40 years after 6 versions published, which powerfully advances the clinical management of CNS tumors. We summarize the publishing pro…

MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma Open

Jinzhang Sun, Jinhao Zhang, Jiabo Li, Feng Yuan, Luqing Tong , et al. · 2021

Background. Glioma is the most common primary intracranial tumor and is associated with poor prognosis. Identifying effective biomarkers for glioma is particularly important. MXRA5, a secreted glycoprotein, is involved in cell adhesion and…

Decoding Spatial Memory Retrieval in Cubical Space Using fMRI Signals Open

Jiahe Guo, Kai Zhang, Jianyu Zhang, Rui Zhao, Yibo Liang , et al. · 2021

The way spatial memory retrieval is represented in the brain remains unclear to date. Previous studies have displayed a hippocampus-centered navigation network using functional magnetic resonance imaging (fMRI) analysis. There have been so…

IKBKE, a prognostic factor preferentially expressed in mesenchymal glioblastoma, modulates tumoral immunosuppression through the STAT3/PD‐L1 pathway Open

Yi Li, Gaochao Guo, Jiabo Li, Xiaoguang Fan, Tao Li , et al. · 2020

Inhibitor of nuclear factor kappa‐B kinase subunit epsilon (IKBKE) plays critical roles in the proliferation, invasion, and epithelial‐mesenchymal transition (EMT) of glioblastoma (GBM). However, as an immune response factor, few studies h…

Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells Open

Lei Chen, Meng Zhu, Shengping Yu, Hai Long, Liang Zhang , et al. · 2020

Compared with noninvasive tumor cells, glioma cells overexpress chemokine receptor type 4 (CXCR4), which exhibits significantly greater expression in invasive tumor cells than in noninvasive tumor cells. C-X-C motif chemokine ligand 12 (CX…

ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma Open

Luqing Tong, Jiabo Li, Qiuying Li, Xuya Wang, Ravi Medikonda , et al. · 2020

ACT001, which is derived from an ancient anti-inflammatory drug, has been shown to cross the blood-brain barrier in preclinical studies and has demonstrated anti-glioblastoma (GBM) activity in clinical trials. However, its pharmacological …

Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses Open

Feng Yuan, Yi Li, Hai Long, Yingshuai Wang, Yihan Yang , et al. · 2019

Background . Ca 2+ release-activated Ca 2+ channels (CRAC) are the main Ca 2+ entry pathway regulating intracellular Ca 2+ concentration in a variety of cancer types. Orai2 is the main pore-forming subunit of CRAC channels in central neuro…

Molecular and clinical characterization of Galectin‐9 in glioma through 1,027 samples Open

Feng Yuan, Haolang Ming, Yingshuai Wang, Yihan Yang, Yi Li , et al. · 2019

In recent years, research on glioma immunotherapy have grown rapidly. However, the autoimmune‐like side effects that are caused by blocking immunological checkpoints hinder their clinical application in gliomas currently. Galectin‐9, a lig…

Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4 Open

Yi Li, Xingchen Zhou, Tao Li, Peidong Liu, Hai Long , et al. · 2019

These findings suggest that the cross-talk between Notch1 signaling and CXCL12/CXCR4 system could contribute to the self-renewal and invasion of GICs, and this discovery could help drive the design of more effective therapies in Notch1-tar…

Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation Open

Zhennan Tao, Tao Li, Haiwen Ma, Yihan Yang, Chen Zhang , et al. · 2018

NKCC1 promotes EMT‐like process in GBM via RhoA and Rac1 signaling pathways Open

Haiwen Ma, Tao Li, Zhennan Tao, Hai Long, Luqing Tong , et al. · 2018

Glioblastoma is the most common and lethal primary intracranial tumor. As the key regulator of tumor cell volume, sodium‐potassium‐chloride cotransporter 1 (NKCC1) expression increases along with the malignancy of the glioma, and NKCC1 has…

Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma Open

Yi Li, Luqing Tong, Tao Li, Hai Long, Iruni Roshanie Abeysekera , et al. · 2018

Glioblastoma multiforme (GBM) is one of the most lethal types of tumour, despite severe treatment methods. The Cancer Genome Atlas has categorised GBMs into proneural, neural, classical and mesenchymal subtypes; the mesenchymal subgroup ha…

Tumour cell dormancy as a contributor to the reduced survival of GBM patients who received standard therapy Open

Luqing Tong, Yi Li, Peidong Liu, Iruni Roshanie Abeysekera, Hai Long , et al. · 2018

Glioblastoma multiforme (GBM) is a fatal cancer with varying life expectancy, even for patients undergoing the same standard therapy. Identification of differentially expressed genes in GBM patients with different survival rates may benefi…

Shengping Yu YOU? Author Swipe