Yuqing Wu
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View article: SIMULATION AND EXPERIMENTAL STUDY ON VIBRATORY HARVESTING PARAMETERS OF A PLUM HARVESTING MACHINE
SIMULATION AND EXPERIMENTAL STUDY ON VIBRATORY HARVESTING PARAMETERS OF A PLUM HARVESTING MACHINE Open
The objective of this study is to address the challenges associated with manual, labor-intensive plum harvesting in hilly and mountainous regions. To overcome these limitations, a crawler-type plum harvester was developed based on the oper…
View article: Enhanced N2 Production via 3D Electrocatalytic Nitrate Reduction on Pd-Cu SACs by P-Doped Bamboo Biochar
Enhanced N2 Production via 3D Electrocatalytic Nitrate Reduction on Pd-Cu SACs by P-Doped Bamboo Biochar Open
View article: Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease
Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease Open
SOM230 alleviates nerve abnormalities in DED by suppressing inflammatory pathways (TNF-α, NF-κB) and promoting a shift in macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype. These findings suggest…
View article: Evaluation and optimization of mumps-containing vaccination strategies: a study based on an individual-based stochastic model
Evaluation and optimization of mumps-containing vaccination strategies: a study based on an individual-based stochastic model Open
National Key Research and Development Program of China (2024YFC2311404).
View article: HPV VLPs-based RNA-delivery system for synergistic BCL-2 silencing and mitochondrial apoptosis in NSCLC cells
HPV VLPs-based RNA-delivery system for synergistic BCL-2 silencing and mitochondrial apoptosis in NSCLC cells Open
Non-small cell lung cancer (NSCLC) resists apoptosis and lacks targeted therapies. We developed a tetra-functional assembly, siRNA_D-pep@VLP-SP5-2, integrating BCL-2 siRNA and a cationic mitochondrial destabilization D-peptide within the S…
View article: Colorimetric Revealing of Ethanol–Water Cluster (E-Wc) Transitions in Binary Solution Based on Starch–I2 Crystallization
Colorimetric Revealing of Ethanol–Water Cluster (E-Wc) Transitions in Binary Solution Based on Starch–I2 Crystallization Open
We have developed a highly sensitive colorimetric probe based on starch–iodine (I2) crystallization for the precise discrimination of ethanol–water clusters (E-Wc) within binary ethanol–water solutions (E-Ws). This probe enables the identi…
View article: SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis
SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis Open
Background Prostate cancer (PCa) is a prevalent cancer and a major cause of cancer-related deaths in men worldwide. Growing evidence indicates that Staphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein e…
View article: New Advances in Small Molecules Targeted at Viral Capsid–Genome Binding
New Advances in Small Molecules Targeted at Viral Capsid–Genome Binding Open
The capsid protein plays a crucial role in the viral life cycle. By interacting with the viral genome, it facilitates the assembly of the nucleocapsid, ultimately leading to the formation of the viral particle. Therefore, interfering with …
View article: Strong partitioning of soil microbial community composition, structure, and resource limitations between the karst positive and negative slopes
Strong partitioning of soil microbial community composition, structure, and resource limitations between the karst positive and negative slopes Open
View article: New Advances in Anti-HIV-1 Strategies Targeting the Assembly and Stability of Capsid Protein
New Advances in Anti-HIV-1 Strategies Targeting the Assembly and Stability of Capsid Protein Open
The HIV-1 capsid has emerged as a highly attractive drug target due to its highly conserved sequence and critical role in the viral life cycle. By disrupting interactions between capsid proteins and impairing the proper assembly or disasse…
View article: Digital Detox and Mental Well-being: A Phenomenological Analysis on How Social Media Use Affects Psychological Health
Digital Detox and Mental Well-being: A Phenomenological Analysis on How Social Media Use Affects Psychological Health Open
The excessive use of social media is linked to cognitive overload and emotional exhaustion, along with reduced emotional well-being. This can prompt individuals to seek a digital detox and use it as a strategy for gaining psychological rel…
View article: Biomechanical Analysis and Clinical Study of Augmented Versus Conventional Endoscopic Orbital Decompression for Dysthyroid Optic Neuropathy
Biomechanical Analysis and Clinical Study of Augmented Versus Conventional Endoscopic Orbital Decompression for Dysthyroid Optic Neuropathy Open
Dysthyroid optic neuropathy (DON) represents a severe ocular complication in thyroid eye disease (TED) that can lead to vision loss. Although surgical decompression is a well-established treatment modality, the optimal decompression area r…
View article: Research on the Color Characteristics of Yanchuan Cloth Appliqu Painting Based on the Munsell-Spencer Color Harmony Theory
Research on the Color Characteristics of Yanchuan Cloth Appliqu Painting Based on the Munsell-Spencer Color Harmony Theory Open
Innovative upgrading based on inherent elements is key to the dynamic inheritance of fabric-based intangible cultural heritage (ICH). Color, as the most intuitive embodiment of aesthetic perception, serves both as an entry point for studyi…
View article: Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages
Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages Open
Our findings underscore the activation of α7nAChR as a pioneering therapeutic approach for preserving corneal nerves balance and controlling inflammation in DED.
View article: The ammonia-Slc4a11 axis in T cells alleviates LPS-induced mastitis
The ammonia-Slc4a11 axis in T cells alleviates LPS-induced mastitis Open
Background Mastitis is an inflammatory condition of the mammary gland, commonly observed in lactating and non-puerperal women, posing significant health and economic challenges. Lipopolysaccharide (LPS), a component of the outer membrane o…
View article: KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway
KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway Open
In this study, we report that KIF26B is upregulated in bladder cancer and acts as an independent prognostic factor. Knockdown of kif26b blocks the proliferation, metastasis, and cisplatin resistance of bladder cancer cells. Mechanistically…
View article: Karst Tiankeng Is the Refuge of Microbial Diversity in the Degraded Karst Landscape
Karst Tiankeng Is the Refuge of Microbial Diversity in the Degraded Karst Landscape Open
Known as the largest negative terrain on the earth's surface, the karst tiankeng is isolated by vertical cliffs and maintains a unique ecosystem within it. However, knowledge of the microbial ecology of karst tiankengs does not match their…
View article: The role and clinical potential of RNA modifications in bladder cancer
The role and clinical potential of RNA modifications in bladder cancer Open
Background: Bladder cancer (BC) represents a common malignancy and is characterized by high heterogeneity and complex biological behaviors, which pose substantial challenges to its effective treatment. Mounting evidence highlights the pivo…
View article: Detection of casein in milk by bilobate-like dyes quinaldine red and thioflavin T
Detection of casein in milk by bilobate-like dyes quinaldine red and thioflavin T Open
View article: Analysis of Two Neuroanatomical Subtypes of Parkinson's Disease and Their Motor Progression Based on Semi‐Supervised Machine Learning
Analysis of Two Neuroanatomical Subtypes of Parkinson's Disease and Their Motor Progression Based on Semi‐Supervised Machine Learning Open
Background The high heterogeneity of Parkinson's disease (PD) hinders personalized interventions. Brain structure reflects damage and neuroplasticity and is one of the biological bases of symptomatology. Subtyping PD in the framework of br…
View article: Supramolecular ethanol-water clusters in alcoholic beverages: Review on 2D correlation fluorescence and NMR spectral characterizations
Supramolecular ethanol-water clusters in alcoholic beverages: Review on 2D correlation fluorescence and NMR spectral characterizations Open
While the studies have revealed that the type and content of ingredients are crucial factors in determining the quality and taste of alcoholic beverages, the liquid-liquid condensed phase of the supramolecular network of ethanol-water clus…
View article: Revealing Ethanol-Water Cluster (E-Wc) Transitions Using a Sensitive Colorimetric Probe
Revealing Ethanol-Water Cluster (E-Wc) Transitions Using a Sensitive Colorimetric Probe Open
View article: Enhanced N2 Production Via Three-Dimensional Electrocatalytic Nitrate Reduction Through Pd-Cu Single Atom on P-Doped Bamboo Activated Biochar
Enhanced N2 Production Via Three-Dimensional Electrocatalytic Nitrate Reduction Through Pd-Cu Single Atom on P-Doped Bamboo Activated Biochar Open
View article: Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications
Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications Open
R-loops, RNA-DNA hybrid structures, are integral to key cellular processes such as transcriptional regulation, DNA replication, and repair. However, aberrant accumulation of R-loops can compromise genomic integrity, leading to the developm…
View article: Ketogenic Diet and Endocrine and Metabolic Diseases: A Bibliometric Study and Visualization Analysis
Ketogenic Diet and Endocrine and Metabolic Diseases: A Bibliometric Study and Visualization Analysis Open
Background: The ketogenic diet, known for its high-fat, low-carbohydrate composition, has been extensively studied in endocrine and metabolic diseases. This study carried out bibliometric analysis to examine the research trends in this fie…
View article: Topical delivery of human single-domain antibody targeting IL-33 for inhibiting mucosal inflammation
Topical delivery of human single-domain antibody targeting IL-33 for inhibiting mucosal inflammation Open
Addressing mucosal inflammatory disorders in the ocular surface or respiratory system remains a formidable challenge due to limited penetration of biological therapeutics across epithelial barriers. In this study, we explored the potential…
View article: N6-methyladenosine-modified circRPS6KC1 regulated cell senescence in prostate cancer via FOXM1/PCNA axis
N6-methyladenosine-modified circRPS6KC1 regulated cell senescence in prostate cancer via FOXM1/PCNA axis Open
Background Prostate cancer (PCa) gradually becomes the most common cancer in men in many countries, of which circRNAs and methylated modification exert an essential role in prostate cancer progression. However, the concrete mechanism of N6…
View article: Highly Dispersive Gold Nanoclusters Confined within Micropores of Defective UiO-66 for Highly Efficient Aldehyde Oxidation at Mild Conditions
Highly Dispersive Gold Nanoclusters Confined within Micropores of Defective UiO-66 for Highly Efficient Aldehyde Oxidation at Mild Conditions Open
The oxidative esterification of aldehydes under mild conditions remains a significant challenge. This study introduces a unique defective UiO-66 to achieve gold nanoclusters (AuNCs) for efficient aldehyde oxidation under mild conditions. T…
View article: Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer Open
View article: Intestinal microecology in pediatric surgery-related gastrointestinal diseases: Current insights and future perspectives
Intestinal microecology in pediatric surgery-related gastrointestinal diseases: Current insights and future perspectives Open
Intestinal microecology is established from birth and is constantly changing until homeostasis is reached. Intestinal microbiota is involved in the immune inflammatory response of the intestine and regulates the intestinal barrier function…