Yu Shang Low
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View article: Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins
Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins Open
ABC toxins are toxin-translocating, pore-forming proteins found in a wide range of insecticidal bacteria and some mammalian pathogens. The Yersinia entomopahaga toxin complex (YenTc) belongs to a distinct subclass of ABC toxins, defined by…
View article: Does simple impedance reflect intrascalar tissue in the implanted cochlea?
Does simple impedance reflect intrascalar tissue in the implanted cochlea? Open
A potential threat to the long-term preservation of electrical and acoustical hearing in cochlear implant patients is the development of fibrous tissue and bone in the scala tympani. Simple impedance measures (impedance = voltage/current; …
View article: Advancements in antibody-drug conjugates as cancer therapeutics
Advancements in antibody-drug conjugates as cancer therapeutics Open
Antibody-drug conjugates (ADCs) represent a promising approach in targeted cancer therapy, combining the targeted precision of antibodies with the potency of cytotoxic payloads to selectively target tumour cell whilst minimising off-target…
View article: A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape
A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape Open
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies. Here, we report on a highly potent bispecific therapeutic that combines an anti-fusion (F) nanobody with an anti-rec…
View article: Structure and antigenicity of divergent Henipavirus fusion glycoproteins
Structure and antigenicity of divergent Henipavirus fusion glycoproteins Open
In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng virus (MojV), and both are divergent from the bat-borne HNV mem…
View article: Recent insights into mechanisms of cellular toxicity and cell recognition associated with the ABC family of pore-forming toxins
Recent insights into mechanisms of cellular toxicity and cell recognition associated with the ABC family of pore-forming toxins Open
ABC toxins are pore-forming toxins characterised by the presence of three distinct components assembled into a hetero-oligomeric toxin complex ranging in size from 1.5–2.5 MDa. Most ABC toxins studied to date appear to be insecticidal toxi…
View article: An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant
An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant Open
The SARS-CoV2 Omicron variant sub-lineages spread rapidly through the world, mostly due to their immune-evasive properties. This has put a significant part of the population at risk for severe disease and underscores the need for anti-SARS…
View article: Genome-Guided Analysis of Seven Weed Species Reveals Conserved Sequence and Structural Features of Key Gene Targets for Herbicide Development
Genome-Guided Analysis of Seven Weed Species Reveals Conserved Sequence and Structural Features of Key Gene Targets for Herbicide Development Open
Herbicides are commonly deployed as the front-line treatment to control infestations of weeds in native ecosystems and among crop plants in agriculture. However, the prevalence of herbicide resistance in many species is a major global chal…
View article: Structure, function and evolution of the orally active insecticidal toxin complex, YenTc
Structure, function and evolution of the orally active insecticidal toxin complex, YenTc Open
Yersinia entomophaga is a naturally occurring, Gram negative insect pathogen, first isolated from the diseased larvae of the New Zealand grass grub C. zealandica a decade ago [1].Its main virulence determinant is YenTc, a heterogenous 2.4 …
View article: Herbicides That Target Acetohydroxyacid Synthase Are Potent Inhibitors of the Growth of Drug-Resistant <i>Candida auris</i>
Herbicides That Target Acetohydroxyacid Synthase Are Potent Inhibitors of the Growth of Drug-Resistant <i>Candida auris</i> Open
Acetohydroxyacid synthase (AHAS, EC 2.2.1.6), the first enzyme in the branched chain amino acid biosynthesis pathway, is the target for more than 50 commercially available herbicides, and is a promising target for antimicrobial drug discov…