Yu Sun
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View article: TUBB1 promoter methylation is a promising biomarker for predicting HBeAg seroconversion in chronic hepatitis B
TUBB1 promoter methylation is a promising biomarker for predicting HBeAg seroconversion in chronic hepatitis B Open
The identification of predictive indices for hepatitis B e antigen seroconversion (HBeAg SC) in patients with chronic hepatitis B (CHB) remains a challenge. We aimed to investigate whether the TUBB1 promoter methylation in peripheral blood…
View article: <scp>KDM4</scp> Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence‐Associated Secretory Phenotype
<span>KDM4</span> Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence‐Associated Secretory Phenotype Open
Cellular senescence restrains the expansion of neoplastic cells through several layers of regulation. We report that the histone H3‐specific demethylase KDM4 is expressed as human stromal cells undergo senescence. In clinical oncology, upr…
View article: Role and mechanism of RPA1 in the development and progression of glioma
Role and mechanism of RPA1 in the development and progression of glioma Open
Glioma is a highly malignant primary tumor of the central nervous system, characterized by highly invasive behavior and a high recurrence rate. The current treatment options for gliomaoften have unsatisfactory outcomes. Replication protein…
View article: Evaluation of Dual-Purpose Triticale: Grain and Forage Productivity and Quality Under Semi-Arid Conditions
Evaluation of Dual-Purpose Triticale: Grain and Forage Productivity and Quality Under Semi-Arid Conditions Open
Triticale (× Triticosecale Wittmack) is a valuable dual-purpose crop due to its adaptability to marginal environments and its potential for both high-quality grain and forage production. However, a comprehensive evaluation of its forage qu…
View article: Relationship between emotional labor strategies and the quality of work life of operating room nurses
Relationship between emotional labor strategies and the quality of work life of operating room nurses Open
Introduction Emotional labor involves regulating one’s emotional state at work to align with organizational expectations. For operating room (OR) nurses, emotional labor is an inherent part of their roles, with different strategies potenti…
View article: Technologies to address Alzheimer’s disease and related dementia care
Technologies to address Alzheimer’s disease and related dementia care Open
View article: Clinical, genetic profile and therapy evaluation of 11 Chinese pediatric patients with Fanconi-Bickel syndrome
Clinical, genetic profile and therapy evaluation of 11 Chinese pediatric patients with Fanconi-Bickel syndrome Open
Background Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive disorder characterized by impaired glucose and galactose utilization as well as proximal renal tubular dysfunction. Methods Clinical, biochemical, genetic, treatment, a…
View article: Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity Open
View article: Clinical, genetic profile and therapy evaluation of 11 Chinese paediatric patients with Fanconi-Bickel syndrome
Clinical, genetic profile and therapy evaluation of 11 Chinese paediatric patients with Fanconi-Bickel syndrome Open
Background: Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive disorder characterized by impaired glucose and galactose utilization as well as proximal renal tubular dysfunction. Reported FBS data from China are scarce. Methods: C…
View article: Correlations between phenotype and gene region-specific episignatures in Rubinstein-Taybi syndrome and Menke-Hennekam syndrome
Correlations between phenotype and gene region-specific episignatures in Rubinstein-Taybi syndrome and Menke-Hennekam syndrome Open
Background: Rubinstein-Taybi syndrome (RSTS) and Menke-Hennekam syndrome (MKHK) are two rare Mendelian disorders presented with variable degrees of intellectual disability and different facial dysmorphism. They are caused by loss-of-functi…
View article: Genetic and clinical characteristics of 24 mainland Chinese patients with <i>CTNNB1</i> loss‐of‐function variants
Genetic and clinical characteristics of 24 mainland Chinese patients with <i>CTNNB1</i> loss‐of‐function variants Open
Background Neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV) is a rare autosomal dominant syndrome, which is caused by the heterozygous germline loss‐of‐function variants in CTNNB1. Methods We evaluated the clin…
View article: Study of Noodle Quality Based on Protein Properties of Three Wheat Varieties
Study of Noodle Quality Based on Protein Properties of Three Wheat Varieties Open
Waxy wheat offers unique benefits in food processing, including improving the smoothness and performance of the product. However, waxy wheat is not yet commercially available. The protein characteristics, including the protein content, sub…
View article: Genome sequencing demonstrates high diagnostic yield in children with undiagnosed global developmental delay/intellectual disability: a prospective study
Genome sequencing demonstrates high diagnostic yield in children with undiagnosed global developmental delay/intellectual disability: a prospective study Open
Genome sequencing(GS) has been applied in the diagnosis of global developmental delay(GDD)/intellectual disability(ID). However, the performance in those with inconclusive results from chromosomal microarray analysis(CMA) and exome sequenc…
View article: Anlotinib Is Active for the Patients Failed From the Prior Antiangiogenic Therapy: Anti-angiogenic Therapy Might Be Cross-line Used
Anlotinib Is Active for the Patients Failed From the Prior Antiangiogenic Therapy: Anti-angiogenic Therapy Might Be Cross-line Used Open
Objective The purpose of this study was to initially investigate whether previous antiangiogenic therapy (bevacizumab and endostar) affect the efficacy of anlotinib in patients with lung cancer (LC). Methods We retrospectively collected th…
View article: Primary immunodeficiency‐related genes in neonatal intensive care unit patients with various genetic immune abnormalities: a multicentre study in China
Primary immunodeficiency‐related genes in neonatal intensive care unit patients with various genetic immune abnormalities: a multicentre study in China Open
Objectives The present phenotype‐based disease classification causes ambiguity in diagnosing and determining timely, effective treatment options for primary immunodeficiency (PID). In this study, we aimed to examine the characteristics of …
View article: Additional file 5 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 5 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 5: Supplementary Table S4. NovaSeq datasets. Publicly accessible studies deposited in NCBI SRA ( https://www.ncbi.nlm.nih.gov/sra ) were reviewed to account for lost read names.
View article: Additional file 9 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 9 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 9: Supplementary Table S8. Surface-level sequencer error rate.
View article: Additional file 3 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 3 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 3: Supplementary Table S2. HiSeq datasets. Publicly accessible studies deposited in NCBI SRA ( https://www.ncbi.nlm.nih.gov/sra ) were reviewed to account for lost read names.
View article: Additional file 2 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 2 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 2: Supplementary Table S1. List of NCBI SRA ( https://www.ncbi.nlm.nih.gov/sra ) studies and associated platform, research institute and country.
View article: Additional file 7 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 7 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 7: Supplementary Table S6. Flow cell-level sequencer error rate.
View article: Additional file 13 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 13 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 13: Supplementary Table S12. Tile-level sequencer error rate estimated using a common reference DNA library.
View article: Additional file 14 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 14 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 14: Supplementary Table S13. Sequencer effect and outlier tile effect on overall error rate of a common reference DNA library.
View article: Additional file 11 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 11 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 11: Supplementary Table S10. Prevalence of outlier tiles at flow cell level.
View article: Additional file 12 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 12 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 12: Supplementary Table S11. Outlier tiles.
View article: Additional file 4 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 4 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 4: Supplementary Table S3. NextSeq datasets. Publicly accessible studies deposited in NCBI SRA ( https://www.ncbi.nlm.nih.gov/sra ) were reviewed to account for lost read names.
View article: Additional file 8 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 8 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 8: Supplementary Table S7. All flow cells affected in an outlier sequencer.
View article: Additional file 6 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 6 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 6: Supplementary Table S5. Sample effect is minimal on flow cell-level analysis.
View article: Additional file 10 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 10 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 10: Supplementary Table S9. Extent of outlier tiles.
View article: Additional file 15 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data
Additional file 15 of SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data Open
Additional file 15: Supplementary Table S14. Sample names of a dataset generated in different sequencing centers by using a common reference DNA library.
View article: A framework for predicting potential host ranges of pathogenic viruses based on receptor ortholog analysis
A framework for predicting potential host ranges of pathogenic viruses based on receptor ortholog analysis Open
Viral zoonoses are a serious threat to public health and global security, as reflected by the current scenario of the growing number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases. However, as pathogenic viruses are …