Yu‐Kang Tu
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View article: A Systematic Review and Network Meta-Analysis of Efficacy of Postmaneuver Rehabilitation in Benign Paroxysmal Positional Vertigo Treatment
A Systematic Review and Network Meta-Analysis of Efficacy of Postmaneuver Rehabilitation in Benign Paroxysmal Positional Vertigo Treatment Open
Background/Objectives: The high prevalence of benign paroxysmal positional vertigo (BPPV) poses a considerable burden on healthcare systems, with an estimated annual cost of 2 billion dollars per year in the United States. The results of p…
View article: Assessing Integrated Care Mechanisms in Taiwan’s Long-Term Care System
Assessing Integrated Care Mechanisms in Taiwan’s Long-Term Care System Open
Background In response to Taiwan's rapidly aging population, the Long-Term Care Plan 2.0 (LTC 2.0) was launched in 2017 to enhance integration across long-term care services, including the establishing of Tier A care management centers. Un…
View article: Suicide risk on Christmas Eve, Christmas Day, New Year's Day, and Valentine's Day: a systematic review and meta-analysis
Suicide risk on Christmas Eve, Christmas Day, New Year's Day, and Valentine's Day: a systematic review and meta-analysis Open
Objective Holidays are times of celebration of family and loved ones which can be difficult for some people. This study assessed the risk of suicide on Christmas Eve, Christmas Day, New Year's Day, and Valentine's Day. Methods We searched …
View article: Lord’s Paradox and two network meta-analysis models
Lord’s Paradox and two network meta-analysis models Open
The contrast-based model (CBM) is the most popular network meta-analysis (NMA) method, although alternative approaches, e.g., the baseline model (BM), have been proposed but seldom used. This article aims to illuminate the difference betwe…
View article: Dose-response efficacy and safety of lumateperone in bipolar depression: A preliminary meta-analysis of randomized controlled trials
Dose-response efficacy and safety of lumateperone in bipolar depression: A preliminary meta-analysis of randomized controlled trials Open
Background: The optimal lumateperone dose for bipolar depression remains uncertain. Aims: To examine its dose–response relationship for efficacy and safety. Methods: We systematically searched major databases to 1 July 2025. Efficacy outco…
View article: Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study
Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study Open
To observe the efficacy and safety of single-access minimally invasive percutaneous nephrolithotomy (MPCNL) combined with flexible cystoscopy and multi-access MPCNL in patients with complex renal stones (CRS). A total of 195 patients with …
View article: Trajectory of efficacy and safety across ulotaront dose levels in schizophrenia: a systematic review and dose–response meta-analysis
Trajectory of efficacy and safety across ulotaront dose levels in schizophrenia: a systematic review and dose–response meta-analysis Open
Background Ulotaront is an experimental antipsychotic for schizophrenia, but its optimal dose is unclear. This study aimed to evaluate dose–response relationships for efficacy and safety in people with schizophrenia. Methods A systematic r…
View article: Long-term outcomes and risk assessment of immediate implants at molar extraction sites in a Taiwan population
Long-term outcomes and risk assessment of immediate implants at molar extraction sites in a Taiwan population Open
This long-term retrospective study evaluated the clinical and radiographic outcomes and assessed the risks associated with immediate molar implants (IMI) in a Taiwan population. This study analyzed the clinical and radiographic records of …
View article: The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis
The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis Open
mABs were associated with a slower progression of cognitive decline than AChEIs; however, this effect did not reach the MID. The incidence of ARIA-E with mABs was associated with APOE4 carrier status and was not indicative of treatment eff…
View article: A systematic review and meta-analysis of herpes zoster risk in adults with immunocompromised conditions and autoimmune diseases in Asia-Pacific
A systematic review and meta-analysis of herpes zoster risk in adults with immunocompromised conditions and autoimmune diseases in Asia-Pacific Open
Asia-Pacific (APAC) faces an increasing burden of herpes zoster (HZ) over time. The risk of HZ and its complications are increased in immunocompromised (IC) patients and those with autoimmune diseases (AID). Our study aimed to synthesize e…
View article: Efficacy of repeated peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis of randomized controlled trials
Efficacy of repeated peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis of randomized controlled trials Open
Background Post-stroke patients with upper motor neuron lesions have limited motor function in the upper limbs, and spasticity occurs in the limbs, thus affecting functional recovery and activities of daily living. Repetitive peripheral ma…
View article: The Efficacy and Acceptability of Non‐Invasive Brain Stimulation Interventions for Obsessive‐Compulsive Disorder Management: A Network Meta‐Analysis Based on 24 Stimulation Methods
The Efficacy and Acceptability of Non‐Invasive Brain Stimulation Interventions for Obsessive‐Compulsive Disorder Management: A Network Meta‐Analysis Based on 24 Stimulation Methods Open
Introduction Despite the high lifetime prevalence and elevated disability rates, treatments for obsessive‐compulsive disorder (OCD) have limited efficacy. Considering the abnormal connectivity in the cortical‐striatal‐thalamic‐cortical loo…
View article: Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses
Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses Open
Our study supported the use of haloperidol for delirium treatment in adult ICU patients, but not for delirium prevention.
View article: Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials
Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials Open
This research was funded by the National Science and Technology Council through grant number NSTC 113-2314-B-006-090, as well as by the National Cheng Kung University Hospital under grant number NCKUH-11303051 and NCKUH-11404024.
View article: Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis
Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis Open
Background The object of this study was to investigate the incidence rate of major adverse cardiovascular event (MACE) among patients with primary aldosteronism (PA) after adrenalectomy or mineralocorticoid receptor antagonist (MRA) treatm…
View article: Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis
Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis Open
Background Nutraceuticals have been taken as an alternative and add-on treatment for depressive disorders. Direct comparisons between different nutraceuticals and between nutraceuticals and placebo or antidepressants are limited. Thus, it …
View article: Trends in the use and nonmedical use of sedatives-hypnotics in the population aged 12 to 64 years in Taiwan: a comparative analysis of the national surveys in 2014 and 2018
Trends in the use and nonmedical use of sedatives-hypnotics in the population aged 12 to 64 years in Taiwan: a comparative analysis of the national surveys in 2014 and 2018 Open
Background Many countries, including Taiwan, have tightened regulations on prescribing sedatives-hypnotics over the concern of their associated adverse health effects. However, it remains seldom investigated whether different age-sex strat…
View article: Response Trajectories and Temporal Trends of Viloxazine Treatment for Young People With ADHD
Response Trajectories and Temporal Trends of Viloxazine Treatment for Young People With ADHD Open
Importance Viloxazine is a novel nonstimulant medication approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). Objectives To investigate the whether viloxazine is associated with effective and acceptable outcomes w…
View article: Effects of different types of intermittent fasting on metabolic outcomes: an umbrella review and network meta-analysis
Effects of different types of intermittent fasting on metabolic outcomes: an umbrella review and network meta-analysis Open
Background Intermittent fasting (IF) holds promise for enhancing metabolic health. However, the optimum IF forms and their superiority over continuous energy restriction (CER) remain unclear due to disconnected findings. Methods We systema…